Searchable abstracts of presentations at key conferences in endocrinology
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22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

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Europe's leading endocrinology congress showcasing the very best in the study and treatment of endocrine disorders.

Audio ePoster Presentations

Endocrine-related Cancer

ea0070aep528 | Endocrine-related Cancer | ECE2020

Sarcopenia can predict response to therapy in NSCLC patients treated with PD-1 inhibitors: A longitudinal prospective study.

Tenuta Marta , Sbardella Emilia , Pandozzi Carla , Gelibter Alain J. , Sirgiovanni Grazia , Giannetta Elisa , Pozza Carlotta , Lenzi Andrea , Isidori Andrea

Introduction: Immune checkpoint inhibitors (ICI) show promising efficacy in the treatment of a wide range of advanced cancers, butlong-term response is currently limited to a subset of patients. Sarcopenia is a condition characterized by loss of skeletal muscle mass and decreased muscle function which occurs in approximately 50% of advanced cancer patients,related to malnutrition, inflammation, and treatments.Objective: The aim of this prospective o...

ea0070aep529 | Endocrine-related Cancer | ECE2020

An Endocrine and metabolic interactomic approach to identify novel diagnostic/prognostic biomarkers and therapeutic targets in gliomas

Perez Gomez Jesus , Fuentes-Fayos Antonio C. , GandiÌa-GonzaÌlez Marisa L. , Cano-Rojas Alberto , Blanco-Acevedo Cristóbal , Negro-Moral Eva M. , Toledano AÌlvaro , Ramos Manuel J. , Ortega-Salas Rosa M. , CerdaÌn Sebastián , GarciÌa-MartiÌn Marisa L. , Luque Raúl M. , Solivera Juan

Gliomas are a common tumor type that affects the glial cells with common features of malignant tumors such as aggressive invasiveness, malignant transformation and vascular proliferation through the central nervous system. Currently, standard therapeutic strategies to treat malignant gliomas are not efficient having alow-rate survival (~12 months). Hence, there is a clear necessity for the identification of novel diagnostic/prognostic tools and therapeutic strategies to m...

ea0070aep530 | Endocrine-related Cancer | ECE2020

Reversal effect of Vitamin D (VitD) on exosome-mediated everolimus resistance (EveR) in hepatocellular carcinoma (HCC) cell line: A molecular study

Gentile Annalisa , Negri Mariarosaria , Montò Tatiana , Patalano Roberta , de Angelis Cristina , Simeoli Chiara , Ferrigno Rosario , Cristina De Martino Maria , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario , Pivonello Claudia

Cancer exosomes emerged as important mediators of cancer drug resistance. Drug exposure-mediated EveR in HCC cell lines can be reversed by VitD pre- and co-treatment. The current study aimed to investigate whether cancer exosomes from EveR HCC cell line are able to induce EveR in parental cells and whether VitD may activate reversal effect on exosome-mediated EveR.To this purpose, parental JHH-6 and EveR JHH-6 cell line were used. The uptakeof exosomes, ...

ea0070aep531 | Endocrine-related Cancer | ECE2020

Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma

Koh Huilin , Au Vanessa , Jia Loh Wann

Introduction: Although the first-line treatment of insulinoma remains to be surgical resection, medical therapy is necessary for non-localizable or non-resectable tumors, poor surgical candidates, or when surgery is declined. We present an interesting case of a patient with well-controlled insulinoma on diazoxide for 5 years who presented acutely with diabetic ketoacidosis (DKA).Case presentation: A 85-year-old female presented to the Emergency Departmen...

ea0070aep532 | Endocrine-related Cancer | ECE2020

Atypical multiple endocrine neoplasia: A case report

Salem Maram Ben , Najla Bchir , Chadia Zouaoui , Besrour Chayma , Laamouri Rihab , Amel Jaidane , Haroun Ouertani

Background: Multiple endocrine neoplasia (MEN) are rare and are characterized by the association of a neoplasia or hyperplasia of at least two endocrine glands. Rare cases of atypical MEN were reported in the literature. We describe a rare combination of acromegaly, papillairy thyroid carcinoma and primary hyperaldosteronism.Case presentation: We report a case of a 48-year old woman operated for papillary thyroid carcinoma. Five years later, sh...

ea0070aep533 | Endocrine-related Cancer | ECE2020

Follow-up case report of an endoscopic ultrasound-guided ethanol ablation: An alternative option for the treatment of pancreatic insulinoma

Vágvölgyi Anna , Nagy Rea , Bor Renáta , Fábián Anna , Sepp Krisztián , Hamar Sándor , Tiszlavicz László , Szepes Zoltán , Valkusz Zsuzsanna

Insulinomas are predominantly benign pancreatic neuroendocrine tumors presenting with hyperinsulinemic hypoglycemia. Patients with significant hypoglycemic episodes can pose a management challenge. Based on the extent and the aggressiveness of the disease patients may be offered different treatment regimens. Although surgical resection is currently the standard treatment for pancreatic insulinoma, alternative treatment options, such as endoscopic ultrasound-guided fine needle ...

ea0070aep534 | Endocrine-related Cancer | ECE2020

Diverse regulation of HIF-1 on VEGF in renal cell carcinoma

Beleslin Cokic Bojana , Damjanovic Svetozar , Bizic Radulovic Sandra , Suboticki Tijana , Cokic Vladan , Milicevic Ivana , Rodic Gordana , Antic Jadranka , Macut Djuro

The clear cell renal cell carcinoma (ccRCC) can be sporadic or familiar, with the mutated von Hippel-Lindau (VHL) gene. The inactive VHL protein prevents degradation of hypoxia inducible factor (HIF) that promotes overexpression of angiogenic factors such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO). Sequencing and multiplex ligation-dependent probe amplification (MLPA) of VHL gene in 43 samples of ccRCC in tumors vs surrounding healthy tissues reveale...

ea0070aep535 | Endocrine-related Cancer | ECE2020

Endocrine related immune adverse events associated with programmed death ligand-1 (PD-L1) therapy in hematologic malignancies: A retrospective analysis

Lo Preiato Valentina , Buganè Anna , Casadei Beatrice , Argnani Lisa , Luigi Zinzani Pier , Pagotto Uberto , Pelusi Carla

Background: PD-L1 represents a novel class of drugs for treatment of a broad spectrum of malignancies including onco-hematologic diseases. This treatment is associated with several immuno-related adverse events (irAEs). Thyroid diseases and diabetes are among the most common PD-L1 endocrine-irAEs reported in solid cancers.Aims: To describe the frequency, the onset and the characteristics of PD-L1 endocrine-irAEs in patients with hematologic malignancies....

ea0070aep536 | Endocrine-related Cancer | ECE2020

Real medical challenges in the diagnostic of gastrinomas

Alexandra Ciobanu Oana , Tieranu Cristian , Terzea Dana , Nistor Irina , Mitrache Marius , Simona Fica

Introduction: Chronic hypergastrinemia is no longer an uncommon phenomenon. Zollinger-Ellison syndrome [ZES], chronic atrophic gastritis [CAG] type A, proton pump inhibitors [PPI] therapy, or Helicobacter pylori-induced CAG type B are causes of hypergastrinemia. Serum gastrin levels >1000 pg/ml (> 0 times the upper limit of normal) and PH gastric below 2 is the diagnostic of ZES, but two -thirds of ZES patients have serum gastrin levels below 1000 pg/ml. We present the...

ea0070aep537 | Endocrine-related Cancer | ECE2020

Pheochromocytoma due to TMEM127 mutation – the importance of genetic test for clinical decision

Paredes Silvia , Lopes Sara , Torres Isabel , Alves Marta

Background: Catecholamine-secreting tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic ganglia are respectively referred to as pheochromocytomas and paragangliomas. The classic triad of symptoms in patients with pheochromocytoma (PHEO)consists of episodic headache, sweating, and tachycardia. Approximately one-half have paroxysmal hypertension; the rest have either primary hypertension or normal blood pressure. Clinicians should always consider P...

ea0070aep538 | Endocrine-related Cancer | ECE2020

Functional and morphologic response to somatostatin analogues of a pancreatic gastrinoma with unusual presentation

Constantin Marinescu Mihai , Baciu Ionela , Pascu Polina , Rotarescu Alexandra , Cristina Baleanu Maria , Poiana Catalina

Introduction: Gastrinoma is rare gastrin-secreting neuroendocrine tumor (NET), usually located in the pancreas or duodenum. The most common presentations of gastrin secreting tumor is Zollinger-Ellison Syndrome (ZES). Only about 10% of patients have non demonstrable ulcer.Case presentation: A 67 years old female, with premature menopause, mild hypothyroidism with optimal replacement treatment, osteopenia and history of chronic gastritis, is admitted to o...

ea0070aep539 | Endocrine-related Cancer | ECE2020

Involvement of the splicing machinery in the antitumoral actions of metformin in prostate cancer

Montero-Hidalgo Antonio J. , Jiménez-Vacas Juan M. , Herrero-Aguayo Vicente , Sarmento-Cabral André , López Miguel , Castaño Justo P , Gahete Manuel D , Luque Raúl M

Metformin has recently emerged as a potential therapeutic tool for different tumour pathologies, including prostate cancer (PCa)1, one of the leading causes of cancer-deaths in men worldwide. However, the molecular mechanisms underlying the antitumor effects of metformin in PCa are not fully elucidated. In this context, previous reports have suggested a relationship between metformin and the process of alternative splicing in some cell-types. Nevertheless, the poten...

ea0070aep540 | Endocrine-related Cancer | ECE2020

Hyponatremia and dermatomyositis as the first manifestations of small cell lung cancer

čikić Elzana , Šahmanović Benida , Delić Majda , Čikić Amil , Bošković Vasilije

Introduction: Dermatomyositis is an inflammatory connective-tissue disease, characterized by inflammation of the muscles and the skin. It is more frequent among women and in 25% of cases it is related to malignancy, such as ovarian, breast, colon cancer, melanoma, non-Hodgkin’s lymphomas, lung cancer, myelo-hyperplastic syndromes, and nasopharyngeal cancer. In 1/3 of cases dermatomyositis precedes malignancy, in 1/3 they present simultaneously, and in the remaining 1/3 o...

ea0070aep655 | Endocrine-related Cancer | ECE2020

Correlation of chromogranin a and standard metabolic parameters in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Bozic-Antic Ivana , Ognjanovic Sanja , Popovic Bojana , Isailovic Tatjana , Bogavac Tamara , Ilic Dusan , Elezovic-Kovacevic Valentina , Macut Djuro

Introduction: Chromogranin A (CgA) is a major representative of the protein family named granins stored predominately in secretory granules of the diffuse neuroendocrine system. Circulating CgA serves as a biomarker of neuroendocrine tumors (NETs), but its increased plasma concentration is present in various cardiovascular, gastrointestinal, renal and inflammatory diseases. Intra-granular and/or extracellular proteolysis of CgA generates a variety of biologically active fragme...