ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
Magnesium supplementation and higher magnesium levels in T2DM patients are associated with better glycemic control and higher rates of total and partial remission post-bariatric surgery
Maria Silva 1,2 , Fernando Mendonça 1,2 , Maria João Fonseca 3 , Maria João Ferreira 1,2 , Daniela Salazar 1,2 , Jorge Pedro 1,2 , Vanessa Guerreiro 1,2 , João Sergio Neves 1,2,4 , Eva Lau 1,2,4 , Sandra Belo 1,2,4 , Ana Varela 1,2,4 , Paula Freitas 1,2,4 & Davide Carvalho 1,2,4
1Centro Hospitalar Universitário São João, Porto, Portugal, Department of Endocrinology, Diabetes and Metabolism, Portugal; 2Universidade do Porto, Faculdade de Medicina, Portugal; 3Institute of Public Health of the University of Porto (ISPUP), Portugal; 4Instituto De Investigação e Inovação em Saúde, Universidade do Porto (I3S), Portugal
Introduction: Magnesium (Mg) is an essential mineral for human health. Chronic Mg2+ deficiency and low Mg2+ dietary intake have been associated with increased risk of T2DM. Despite the increased risk of T2DM associated with Mg2+ deficiency; T2DM is often accompanied by hypomagnesemia, especially in patients with poorly controlled glycemic profiles.
Bariatric surgery remains the most effective long-term therapy for the management of patients with severe obesity. After surgery, micronutrient deficiencies are one of the most common and compelling problems.
Objective: To analyse the effect of Mg supplementation and serum levels in T2DM metabolic parameters and remission after bariatric surgery.
Methods: We performed a cross-sectional study of obese patients who underwent bariatric surgery. Data was assessed preoperatively and one-year after surgery. T2DM was defined as fasting plasma glucose (FPG) ≥126 mg/dl, glycated haemoglobin (HbA1c) ≥6.5%, 2-h plasma glucose after a 75-g oral glucose tolerance test ≥200 mg/dl or the use of anti-diabetic medication (ADM). Complete T2DM remission was defined as HbA1C < 6.0% and no ADM use and partial T2DM remission was defined as HbA1C < 6.5% and no ADM use.
Results: Of a total of 2241 patients submitted to bariatric surgery, we included 644 patients with T2DM. At baseline, 39% of the patients (n = 251) had Mg deficiency and only 4% of them were on Mg supplementation. Patients with Mg deficiency had poorer metabolic control (HbA1c, FPG, insulin, C peptide, HOMA-IR and number of ADM) compared with patients without Mg deficiency with statystical significance for HbA1c (HbA1c = 6.55 ± 1.34 vs HbA1c = 7.17 ± 1.55, P < 0.0001), FPG (FPG = 112.45 ± 28.28 vs FPG = 122 ± 42.58, P < 0.006), and number of ADM (ADM = 1.063 ± 0.89 vs ADM = 1.39 ± 1.07, P < 0.0001). At the first year, 16.1% of patients had complete T2DM remission. It was more common among patients without Mg deficiency (P < 0.001). Similar to baseline, patients withoug Mg deficiency had better metabolic control with statystical significance.
Conclusion: Mg supplementation and higher serum Mg levels in patients with T2DMwere associated with better metabolic control and higher rates of complete and partial remission at the first year post-surgery.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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