Bone and Calcium

ea0070aep122 | Bone and Calcium | ECE2020

Phase 3b open-label study of burosumab in adults with X-linked hypophosphatemia (XLH): Baseline and Week 12 results

Kamenický Peter , Javaid Kassim , Keen Richard , Lachmann Robin , Ralston Stuart , Cohen-Solal Martine , Brandi Maria , Briot Karine , Crowley Rachel , Walsh Jennifer , Kolta Sami , Rylands Angela , Sun Wei , Nixon Annabel

Introduction: Burosumab, a fully human monoclonal antibody to fibroblast growth factor 23 (FGF23), is the only approved treatment for XLH, a rare genetic disorder characterized by renal phosphate wasting and substantial cumulative musculoskeletal morbidity. BUR02 (NCT03920072) is a European phase 3b open-label study monitoring the long-term safety and efficacy of burosumab in adults with XLH from sites who participated in the CL303/CL304 studies (NCT02526160/02537431).<p c...

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ea0070aep123 | Bone and Calcium | ECE2020

Usefulness of parathormone (PTH) needle washout measurement vs MIBI scintiscan in localization of parathyroid adenoma- a single--center based preliminary study

Filipowicz Dorota , Szczepanek-Parulska Ewelina , Ruchala Marek

Introduction: An accurate identification of affected parathyroid is crucial for implementation of mini-invasive surgery techniques and therefore reduction of complication rate. A few centers postulate measuring washout parathormone (PTH)concentrationin suspected lesions, despite lack of established cut-off point for concentration values and validated measurement methods. Thisprospective study aimed to compare washout PTH assessment vs MIBI scintiscan in terms of efficacy in lo...

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ea0070aep124 | Bone and Calcium | ECE2020

«Angio Scan-01» for extraskeletal calcification assessment in patients with mineral and bone disorders in chronic kidney disease

Maganeva Irina , Volodicheva Victoria , Eremkina Anna , Aynetdinova Alina , Mokrysheva Natalia

Background: Mineral and bone disorders in chronic kidney disease (CKD-MBD) is a systemic disorder of mineral metabolism due to CKD, which is manifestedby abnormalities of calcium, phosphorus, parathormone (PTH) and vitamin D; renal osteodystrophy; extraskeletal calcification. In patients with CKD, vascular calcification occurs 10–20 years earlier than in the general population, and is highly prevalent (40–92%) in the hemodialysis population. «AngioScan-01&#187...

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ea0070aep125 | Bone and Calcium | ECE2020

Impaired bone health at cancer diagnosis in paediatric patients

Nikita Maria , Doulgeraki Artemis , Kanaka-Gantenbein Christina , Karavanaki Kyriaki , Servitzogloy Marina , Athanasopoulou Helen , Polyzois George , Tsentidis Charalampos , Baka Margarita , Kossiva Lydia

Objectives: To evaluate the skeletal profile of paediatric patients with cancer at diagnosis.Methods: Children diagnosed with cancer in our Oncology Centre were recruited during a two-year period and underwent metabolic bone profile and dual-energy X-ray absorptiometry (DXA) at the time of diagnosis.Results: 88 children were evaluated (51 boys, 53 prepubertal), aged 7.6 ± 4.6 years. Of those, 50 were diagnosed with haematologi...

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ea0070aep126 | Bone and Calcium | ECE2020

Abstract unavailable...

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ea0070aep127 | Bone and Calcium | ECE2020

Familial hypocalciuric hypercalcemia in a young man: Grey zones of the differential diagnosis in 10-year clinical follow up

Zajickova Katerina , Moravcova Jitka , Včelák Josef

Herein, we report currently a 39-year old male with a 13-year history of asymptomatic hypercalcemia (mean 2.88 mmol/l; reference range 2.15–2.55 mmol/l) and mildly elevated parathyroid hormone (mean 68.7 ng/l; reference range 15–65 ng/l). Initially, in years 2007–2010 his laboratory picture was compatible with the diagnosis of Familial hypocalciuric hypercalcemia (FHH) with calcium-to-creatinine clearance ratio (Ca/Cr) between 0.008–0.009.Genetic testin...

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ea0070aep128 | Bone and Calcium | ECE2020

Ultrasound-guided laser thermal ablation for parathyroid adenomas - preliminary report

Kochman Magdalena , Waldemar Misiorowski , Wojciech Zgliczyński

Background: The curative therapy of primary hyperparathyroidism (pHPT) is surgery. Data about ultrasound-guided laser ablation (LA) of parathyroid tumor are limited, however it could be a solution for patients with high surgery or anesthetic risk. We report our experience on LA of parathyroid tumors in 11 patients with pHPT with high surgery or anesthetic risk.Methods: LA was performed under ultrasound guidance with an output power of 3W. Total energy an...

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ea0070aep129 | Bone and Calcium | ECE2020

The picture of primary hyperparathyroidism in Italy: Proceeding from hyperparanet survey

Saponaro Federica , Cetani Filomena , Mazoni Laura , Apicella Matteo , Pardi Elena , Borsari Simona , Marcocci Claudio

This is a multicentre retrospective observational study, with the aim to characterize the presentation, management and cure rate of Primary Hyperparathyroidism (PHPT) in Italy. Sixty-one Italian Centres of Endocrinology participated in the study. Clinical, biochemical and instrumental records of 2173 patients with diagnosis of PHPT were collected on a specific online platform (Hyperparanet). Patients were 1808 females (83.2%) and 365 males (16.8%). Diagnosis of PHPT was made a...

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ea0070aep130 | Bone and Calcium | ECE2020

Phase II study of the impact of AZD4017, a selective 11β-HSD1 inhibitor, on osteocalcin in post-menopausal osteopenia

Abbas Afroze , Eastell Richard , K Crowley Rachel , Ainsworth Gemma , Brown Sarah , Flanagan Louise M , Fairclough Rebecca J , Stewart Paul M

The causative link between circulating glucocorticoid excess and osteoporosis is established. Although circulating cortisol levels do not change significantly with age, local tissue metabolism may be implicated in age-related bone loss. The enzyme11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) increases local cortisol production, is expressed in human osteoblasts and its activity increases with age leading to a decrease in bone formation. We hypothesised that sele...

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ea0070aep131 | Bone and Calcium | ECE2020

Changes in the relative expression of circulating microRNAs linked to bone metabolism in HIV-infected Individuals with low bone mass

Yavropoulou Maria , Kolynou Artemis , Makras Polyzois , Skoura Lemonia , Nanoudis Sideris , Pikilidou Maria , Tsave Olga , Metallidis Simeon , Chatzidimitriou Dimitris

Objective: Human immunodeficiency virus (HIV)-infected patients demonstrate an increased risk of osteoporosis and fractures. The pathophysiology of HIV-induced bone loss is complex and remains largely unknown. Recent studies have identified a molecular signature of small non-coding RNAs (microRNAS) in patients with osteoporosis, but data are lacking in HIV-infected patients. The aim of the present study was to investigate the expression profile of microRNAs related to bone met...

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ea0070aep132 | Bone and Calcium | ECE2020

Denosumab associated risk of malignancy- systematic review and meta-analysis of randomized controlled trials

Diker-Cohen Talia , Rosenberg Dana , Avni Tomer , Tsvetov Gloria , Gafter-Gvili Anat

Context: Possible increased risk of malignancy in patients treated with denosumab has been concerned due to inhibition of the immune modulator receptor activator of nuclear factor κ-B ligand.Objective: To assess the risk of malignancy associated with denosumab treatment.Data Sources: PubMed and Cochrane Central Register of Controlled Trials were searched up to May 27, 2019.Study Selection: All randomized...

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ea0070aep133 | Bone and Calcium | ECE2020

Prevalence and determinants of radiological vertebral fractures in a cohort of patients with Klinefelter syndrome

Vena Walter , Pizzocaro Alessandro , Amer Myriam , Indirli Rita , Maffezzoni Filippo , Ferrante Emanuele , Delbarba Andrea , Balzarini Luca , Ferlin Alberto , Mantovani Giovanna , Lania Andrea , Mazziotti Gherardo

Klinefelter syndrome (KS) is a frequent form of male hypogonadism that may be associated with a series of comorbidities potentially affecting quality of life and survival. As a matter of fact, KS was shown to negatively impact skeletal health. However, the studies so far published on this topic were mainly focused on evaluation ofbone mineral density (BMD) and bone microstructure, whereas data on fracture risk are still lacking. In this cross-sectional study, we evaluated for ...

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ea0070aep134 | Bone and Calcium | ECE2020

Radiofrequency Echographic Multi Spectrometry (REMS) evaluation in patients with primary osteoporosis and primary hyperparathyroidism

Grassi Giorgia , Palmieri Serena , Cairoli Elisa , Chiodini Iacopo , Arosio Maura , Eller Vainicher Cristina

Background: Radiofrequency Echographic Multi Spectrometry (REMS) is a new ultrasound-based tool for bone mineral density (BMD) measurement, recently approved by FDA for the use in clinical routine to diagnose osteoporosis (OP) and to monitor bone changes. However, data on patients with secondary OP are not available. The aim of our study was to compare REMS and DXA ability in identifying clinical (cFX) and morphometric vertebral fractures (VFx) in patients with primary OP (pOP...

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ea0070aep135 | Bone and Calcium | ECE2020

Melatonin affects hypoxia-stressed cardiomyocyte differentiation of mouse embryonic stem cells

Jeung Eui-Bae , Lee Jae-Hwan , Mi Park Seon , Jeong Sunhwa , Yoo Yeong-Min

Hypoxia causes oxidative stress and is known to affect cardiovascular dysfunction and the programming of cardiovascular disease. Melatonin is the hormone released primarily from the pineal gland and has been proven to be an antioxidant. Melatonin promotes the expression of antioxidant enzymes such as superoxide dismutase and catalase. To confirm the effect of hypoxia on the differentiation of mouse embryonic stem cells (mESCs) into cardiomyocytes, hypoxia condition induced dur...

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ea0070aep136 | Bone and Calcium | ECE2020

Hypercalcaemia in pregnancy due to parathyroid adenoma – would you recognise it?

Bitar Asma , Jugnarain Davina , Al-Khayfawee Ahmed , Mahamud Bashir , Hossain Belayet , Patel Shirin , Reddy Kotha Swetha , Ramineni Aruna , Mlawa Gideon

Introduction: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder in the general population, with a prevalence of 0.1 to 0.4%, caused by a solitary parathyroid adenoma in 80 to 85% of cases. In pregnancy, however, it is rare and usually manifests with non-specific symptoms leading to the delay in diagnosis A 33-year-old female patient who wasreviewed in obstetrics clinic at 15/40 weeks gestation. She complained of body aches, intermitted nausea and v...

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ea0070aep137 | Bone and Calcium | ECE2020

Are young primary hyperparathyroidism patients differ from older ones regarding clinical and biochemical features?

Burçak Polat Şefika , Evranos Ogmen Berna , Ozdemir Didem , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Introduction: Primary hyperparathyroidism (PHPT) is a prevalent endocrinologic disease and the most common cause of hypercalcemia. PHPT usually affects the elderly. PHPT younger than 40 years of age is less frequent. In young patients especially for ones younger than 30 years of age, screening for familial syndromes such as MEN 1 and MEN 2A is recommended. However, in most of the cases genetic tests are negative and evidence for other endocrine components are absent. Herein th...

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ea0070aep138 | Bone and Calcium | ECE2020

A new and valuable predictor for the diagnosis of primary hyperparathyroidism: Ca/P Ratio

Bestepe Nagihan , cuhaci Neslihan , Polat Burcak , Ogmen Berna , Ersoy Reyhan , Cakir Bekir

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder that is characterized by hypercalcemia and elevated or normal levels of parathyroid hormone (PTH). Most PHPT cases are incidentally discovered when routine laboratory analysis reveals hypercalcemia. PHPT should be considered in any person with elevated serum calcium (Ca) levels and no clear evidence of malignancy. Serum phosphorus (P) is low due to the phosphaturic effects of PTH and mostly in the ...

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ea0070aep139 | Bone and Calcium | ECE2020

Comparative efficacy of parathyroidectomy and conservative management in patients with mild primary hyperparathyroidism: A systematic review and meta-analysis of randomized-controlled studies

Anagnostis Panagiotis , Vaitsi Konstantina , Veneti Stavroula , Papavramidis Theodosios , Kenanidis Eustathios , Potoupnis Michael , Tsiridis Eleftherios , Goulis Dimitrios

Objective: Whereas parathyroidectomy (PTx) has an established benefit in patients with symptomatic primary hyperparathyroidism (PHPT), its efficacy in patients with mild (asymptomatic) PHPT has not been proven. The aim of this study was to systematically investigate and meta-analyze the best available evidence from randomized-controlled trials regarding the efficacy of PTx on fracture risk (primary endpoint), as well as bone mineral density (BMD), serum calcium concentrations,...

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ea0070aep140 | Bone and Calcium | ECE2020

Prevalence of hypoparathyroidism in the EU: A systematic review and meta-analysis

Karpf David , Catsburg Chelsea , Smith Alden

Background: Hypoparathyroidism (HP) is caused by a group of heterogenous conditions that result in deficient secretion of parathyroid hormone. Due to this heterogenous nature, information on HP prevalence is highly variable and studies can be difficult to compare. This study aims to estimate the true prevalence of HP within the EU via comparison of available literature and analyses of sub-populations.Methods: MEDLINE and EMBASE were systematically search...

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ea0070aep141 | Bone and Calcium | ECE2020

Identifying clinical characteristics of hypoparathyroid patients in turkey: The ‘HIPOPARATURK-NET Study’

Konca Degertekin Ceyla , Gogas Yavuz Dilek , Pekkolay Zafer , Ugur Kader , Or Koca Arzu , Topaloğlu Ömercan , Ozdemir Kutbay Nilufer , Aydoğan Ünsal Yasemin , Yilmaz Nusret , Omma Tülay

Hypoparathyroidism is a rare endocrine disorder whose epidemiologic characteristics regarding the cause, clinical course, acute and chronic complications have not been well defined. There is also a substantial geographic variability regarding those parameters, and country-specific local data is scarce.This study was conducted to assess the baseline characteristics, including the demographics, etiologic distribution, disease severity, medications use...

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ea0070aep142 | Bone and Calcium | ECE2020

The prevalence of postoperative (PO) chronic hypoparathyroidism (HypoPTH) in bilbao, northern spain

Oleaga Amelia , Goñi Fernando , Moreno Cristina , Iglesias Natalia , Calles Laura , Monzon Andoni , Martinez Adela , Merlo Ignacio , Gutierrez Teresa , Ruiz de Velasco Elena , Paja Miguel

Introduction: HypoPTH is an uncommon disorder, mostly due to anterior neck surgery. The prevalence of HypoPTH has been studied in surgical series and registries, (USA, Denmark and Hungary) where only a minority of patients has HypoPTH due to non-surgical causes. In Spain data on PO HypoPTH in endocrinologist clinical practice has been published recently. The aim of this study was to establish the prevalence of chronic PO HypoPTH in Bilbao area, with a population 2019: 346,843....

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ea0070aep143 | Bone and Calcium | ECE2020

Osteocalcin may participate to the bone-parathyroid crosstalk through activation of the calcium-sensing receptor in human parathyroid adenomas

Verdelli Chiara , Stefania Tavanti Giulia , Maggiore Riccardo , Mari Gilberto , Sansoni Veronica , Perego Silvia , Vicentini Leonardo , Dalino Ciaramella Paolo , Lombardi Giovanni , Corbetta Sabrina

Parathyroid glands regulate bone metabolism through PTH, while bone modulates parathyroid function through calcium and FGF23. Bone releases the matrix protein osteocalcin (OC), whose hormone function is increasingly evident. We tested the hypothesis that OC may modulate parathyroid function. The 6 hours-stimulation of human parathyroid cells derived from adenomas (PAds) (n = 5) with γ-carboxylated OC (GlaOC; 40–60 ng/ml) increased the expression levels ...

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ea0070aep144 | Bone and Calcium | ECE2020

Long-term effectiveness of asfotase alfa in adults with pediatric-onset hypophosphatasia in routine clinical practice

Seefried Lothar , von Hehn Ulrike , Rak Dominik , Petryk Anna , Genest Franca

Hypophosphatasia (HPP) is a rare, inherited, metabolic disorder caused by deficient tissue-nonspecific alkaline phosphatase activity. A heterogeneous presentation in adults includes musculoskeletal symptoms, impaired physical function, and reduced health-related quality of life (HRQoL). Asfotase alfa is the only approved treatment for pediatric-onset HPP. We evaluated, in a real-world setting, the long-term effectiveness of asfotase alfa on physical function and HRQoL among ad...

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ea0070aep145 | Bone and Calcium | ECE2020

Prevalence of osteoporosis, vertebral fractures and hypogonadism in HIV-infected men.

Chiara Pezzaioli Letizia , Porcelli Teresa , Maffezzoni Filippo , Facondo Paolo , Di Lodovico Elena , Delbarba Andrea , Properzi Martina , Cappelli Carlo , Castelli Francesco , Eugenia Quiros Roldan Maria , Ferlin Alberto

With HAART (Highly Active Anti-Retroviral Therapy) introduction, HIV infection history has radically changed. Increased survival has led to new complications, including osteoporosis. The pathogenesis of osteoporosis in HIV patients is multifactorial: virus, HAART, smoking, alcohol, physical inactivity, comorbidities, and hypogonadism can interact in bone depletion.Aim of this study was to evaluate the prevalence of osteoporosis, vertebral fractures (VF) ...

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ea0070aep146 | Bone and Calcium | ECE2020

Bone metabolism in patients with extreme insulin resistance (IR) syndromes

Kushchayeva Yevgeniya , Abdullah Idri , Kushchayev Sergiy , Auh Sungyoung , Startzell Megan , Cochran Elaine , Brown Rebecca

Introduction: Diabetes is associated with increased fracture risk both in patients with type 1 (T1D) and type 2 diabetes (T2D) despite differences in bone mineral density BMD (decreased in T1D and increased in T2D). In T2D, insulin resistance (IR) is selective, with some insulin signaling pathways impaired, while others are overactive due to hyperinsulinemia. It is not clear how different insulin signaling pathways might contribute to the bone phenotypes observed in diabetes. ...

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ea0070aep147 | Bone and Calcium | ECE2020

Core muscles trainig for muscle strength improvement in patients with osteoporotic compression vertebral fractures

Makarova Ekaterina , Marchenkova Larisa , Eryomushkin Mikhail

Aim: To estimate the effect of new complex physical rehabilitation program on core muscles strength in patients with osteoporotic vertebral fractures (VFs).Materials and methods: Study comprised of 90 osteoporotic patients aged 50–80 (65.4 ± 9.1 years) with low-traumatic VFs who were randomized as 2:1 into intervention group (group1, n = 60) and control group (group2, n = 30). Patients in group1 received an intensive ...

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ea0070aep148 | Bone and Calcium | ECE2020

Successful quantification of symptom load by a disease-specific questionnaire HPQ 40/28 and analysis of influencing biochemical parameters in patients with postsurgical hypoparathyroidism

Wilde Deborah , Wilken Lara , Stamm Bettina , Heppner Christina , Leha Andreas , Blaschke Martina , Herrmann-Lingen Christoph , Siggelkow Heide

In hypoparathyroidism (HypoPT), patients suffer severely from reduced quality of life. The complexity of HypoPT demands a disease-specific control instrument to characterize symptom load. We employed a newly developed disease-specifichypoparathyroid patient questionnaire (the HPQ 40/28) to investigate and quantify HypoPT patients’ complaints and contributing factors. In this cross-sectional, two-center study, patients with postsurgical HypoPT (n = 49) were m...

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ea0070aep149 | Bone and Calcium | ECE2020

Investigation of total- and free-25OHD levels by different methods in pregnant women

Tüttő Ágnes , Balázs Karvaly Gellért , Gerszi Dóra , Várbiró Szabolcs , Lőcsei Zoltán , Konderak Judit , Toldy Erzsébet

Avoiding vitamin D deficiency can be beneficial in prevention of adverse maternal, fetal and neonatal outcomes. Because of increasing level of vitamin D-binding protein (DBP) in pregnancy, the determination of free-25OHD should be required, whose adequate measure is a challenge for the analytics. Literature data are contradictory whether total-or free-25OHD fraction is more reliable taking into consideration the methods of measurement. Data of publications on free or total, bi...

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ea0070aep150 | Bone and Calcium | ECE2020

Analysis of 25OHD levels in chronic renal failure depending on the methods

Toldy Erzsébet , Konderak Judit , Kovács László , Tüttő Ágnes , Balázs Karvaly Gellért , Lőcsei Zoltán

Vitamin D deficiency is common in patients with chronic renal failure (CRF) based on routinely determined total-25-hydroxyvitaminD (t-25OHD) levels. The present knowledge is contradictory whether the direct measured free-25OHD (dm_f-25OHD) or the calculated free-25OHD (c_f-25OHD) is the best indicator of the vitamin D supply for CRF patients. Adding methods to our previously described first experiences on this subject, in this study we aimed to serve newer data to make this qu...

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ea0070aep151 | Bone and Calcium | ECE2020

Cardiovascular status in chronic hypoparathyroidism – a single-center analysis in 133 patients compared to the general german population

Teresa Fuss Carmina , Gronemeyer Karen , Hermes Franca , Dörr Marcus , Koschker Ann-Cathrin , Nordbeck Peter , Hannemann Anke , Hahner Stefanie

Introduction: Even though it is well known that long-term complications, such as renal insufficiency and brain calcifications can occur in patients with hypoparathyroidism (HPT), the risk of cardiovascular diseases still remains unclear.Objective: To perform a systematic assessment of cardiovascular function in a well-characterized cohort of patients with HPT compared to population-based controls.Methods: 133 patients with chronic ...

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ea0070aep152 | Bone and Calcium | ECE2020

Renal complications in chronic hypoparathyroidism – a german single-center analysis in 169 patients

Gronemeyer Karen , Teresa Fuss Carmina , Hermes Franca , Plass Armin , Koschker Ann-Cathrin , Hahner Stefanie

Introduction: Although long-term complications such as nephrocalcinosis and renal insufficiency are well-known in chronic hypoparathyroidism (HPT), standardized investigations of their prevalence and causes are still lacking.Objective: To systematically investigate the prevalence of renal calcifications and dysfunction and their predictors in a well-characterized cohort of patients with HPT.Methods: Cross-sectional assessment of co...

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ea0070aep153 | Bone and Calcium | ECE2020

Risk of fractures in primary hyperparathyroidism: A systematic review and metaanalysis

Svensson Henriette , Rolighed Lars , Harsløf Torben , Rejnmark Lars

Background and objectiveAn increased risk of fractures in Primary Hyperparathyroidism (PHPT) has been reported in a number of relatively small studies. Performing a systematic literature search we identified available studies and calculated common estimates by pooling results from the individual studies in a meta-analysis.Methods: Searching EMBASE and PubMed using both free text word search and Mesh terms we identified published st...

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ea0070aep154 | Bone and Calcium | ECE2020

Psychiatric Comorbidities in Chronic Hypoparathyroidism – a German Single-Center Analysis in 107 Patients

Teresa Fuss Carmina , Hermes Franca , Koschker Ann-Cathrin , Unterecker Stefan , Deckert Jürgen , Hahner Stefanie

Introduction: Reduction of quality of life in patients with chronic hypoparathyroidism (HPT) has been reported by several studies. Additionally, self-report data point to a higher prevalence of anxiety disorders in HPT compared to patients after thyroidectomy.Objectives: To characterize psychiatric diseases in a systematically reviewed cohort of patients with chronic HPT.Methods: We systematically assessed psychiatric comorbidities...

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ea0070aep155 | Bone and Calcium | ECE2020

Do near-infrared intra-operative findings by the use of indocyanine green correlate with post-thyroidectomy parathyroid function? - the ICGPREDICT study

Papavramidis Thedosios , Anagnostis Panagiotis , Chorti Angeliki , Pliakos Ioannis , Panidis Stavros , Koutsoumparis Dimitris , Michalopoulos Antonios

Background/Aims: Post-operative hypoparathyroidism still remains a significant complication after thyroidectomy. Intraoperative imaging modalities, such as near infrared fluorescence by the use of indocyanine green (ICG), may assist to identify and preserve the parathyroid glands (PGs). The purpose of this study was to test the association between intra-operative ICG staining scoring system and 24-h post-operative parathyroid hormone (PTH) levels, as well as its capability of ...

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ea0070aep156 | Bone and Calcium | ECE2020

DXA scanning in primary hyperparathyroidism: Should forearm DXA be performed routinely?

Piskinpasa Hamide , Ciftci Dogansen Sema , Metin Duygu , Alper Sahbaz Nuri , Aydın Husnu , Esen Ayse , Bozkur Evin , Turgut Seda , Pamuk Naim , Cakir Ilkay , Mert Meral

Introduction: Primary hyperparathyroidism (PHPT) is a disease associated with a decrease in bone mineral density (BMD), especially in cortical bones such as distal radius. Therefore, the BMD measurement of forearm is valuable in the detection of cortical bone loss by PHPT. However, forearm measurement is not routinely recommended for the diagnosis of osteoporosis in PHPT. In this study, we aimed to evaluate the importance and priority of forearm BMD measurement in PHPT.<p ...

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ea0070aep157 | Bone and Calcium | ECE2020

Burden of illness in patients with chronic hypoparathyroidism not adequately controlled with conventional therapy: A survey of physicians in belgium and the Netherlands

Hamdy Neveen AT , Decallonne Brigitte , Evenepoel Pieter , Gruson Damien , Marelli Claudio , van Vlokhoven-Verhaegh Liza

Patients with hypoparathyroidism are at risk of short-term and long-term complications and comorbidities, such as renal, cardiovascular, metabolic or cognitive manifestations. The purpose of this study was to determine the burden of illness (BOI) in patients with not adequately controlled chronic hypoparathyroidism receiving conventional therapy (oral calcium supplements and active vitamin D) in Belgium and the Netherlands. Data werecollected from a cross-sectional, 2-part onl...

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ea0070aep158 | Bone and Calcium | ECE2020

Burden of illness in patients with chronic hypoparathyroidism not adequately controlled with conventional therapy: European subanalysis of a global patient survey

Siggelkow Heide , Germak John , Marelli Claudio , Chen Kristina , Dahl-Hansen Helen , Glenister Elizabeth , Bent-Ennakhil Nawal , Judge Davneet , Mycock Katie , Clarke Bart L

Although chronic hypoparathyroidism is known to negatively affect health-related quality of life (HRQoL), burden of illness is less well defined in patients whose disease is not adequately controlled on conventional therapy. We report burden of illness for the European subset of a patient survey in 13 countries globally. 398 adults with chronic hypoparathyroidism not adequately controlled on conventional therapy (recruited by treating physician or patient association) complete...

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ea0070aep159 | Bone and Calcium | ECE2020

Clinical features and management of primary hyperparathyroidism discovered by parathyroid incidentaloma

Pandzic Jaksic Vlatka , Majic Ana , Andric Jelena , Cigrovski Berkovic Maja , Marusic Srecko

Primary hyperparathyroidism (PHPT) is nowadays usually diagnosed as an asymptomatic disease but it might be related with advanced end-organ damage. Parathyroid incidentaloma (PI) is the term describing enlarged parathyroid nodules that are unexpectedly discovered on surgery or by imaging performed for nonparathyroid disorders. The recognition of PI might uncover a clinically significant PHPT with the potential for surgical cure. We retrospectively reviewed patients’ reco...

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ea0070aep160 | Bone and Calcium | ECE2020

Serum and tissue expression profile of microRNAs that regulate genes related to the pathogenesis of sporadic parathyroid adenomas

Yavropoulou Maria , Pazaitou-Panayiotou Kalliopi , Makras Polyzois , Anastasilakis Athanasios , Poulios Chris , Daskalaki Emily , Chrysafi Sofia , Vamvakidis Kyriakos , Vlachodimitropoulos Dimitris , Yovos John

Background: Epigenetic changes appear to be implicated in the development of parathyroid tumors. In this study we investigated the microRNA expression profile in the serum and tissue samples from patients with primary hyperparathyroidism (PHP) due to sporadic parathyroid adenomas (SPAs).Methods: Our study cohort consisted of 40 patients with PHP due to SPAs that underwent parathyroidectomy (PTX).MicroRNA extraction was performed fr...

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ea0070aep161 | Bone and Calcium | ECE2020

The use of PET/CT with 11C-methionine for the diagnosis of a patient with renal hyperparathyroidism

Kolodziej Maciej , Saracyn Marek , Brodowska-Kania Dorota , Niemczyk Stanislaw , Kaminski Grzegorz

Background: Renal hyperparathyroidism (rHPT) may affect up to 30% of dialysispatients with end-stage renal disease (ESRD). rHPT is associated with an increased risk of cardiovascular events (CE) and bone diseases such as pain or renal osteodystrophy. Total or subtotal parathyroidectomy may be a chance to reduce the severity of the symptoms and decrease the risk of CE and death. Pre-operative scintigraphy and ultrasound diagnostics in rHPT may be insufficient at even up to 60% ...

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ea0070aep162 | Bone and Calcium | ECE2020

Oncogenic osteomalacia – from diagnosis to recovery in 7 days

Zalewska Ewa , Płoszaj-Neć Monika , Orzechowska-Pawiłojć Anna , Śledziński Maciej , Biernat Wojciech , Kaniuka-Jakubowska Sonia , Sworczak Krzysztof

Introduction: Oncogenic Osteomalacia (OO) is a rare paraneoplastic syndrome, resulting from fibroblast growth factor 23 overproduction. The rarity of the disease and nonspecific symptoms often cause delay in diagnosis by months, or even years. There are two cornerstones in the diagnostic process. The first concerns clinical identification, where awareness of this uncommon ailment combined with hypophosphatemia and clinical signs may be sufficient to identify OO. The second inv...

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ea0070aep163 | Bone and Calcium | ECE2020

Case report: Refractory hypercalcemia due to a pancreatic neuroendocrine tumor misdiagnosed as adenocarcinoma

Hage Mirella , Hescot Ségolène , Asnacios Amani , Bakopoulou Sophia , Cazabat Laure , Houillier Pascal , Jean Francois Emile , Raffin-Sanson Marie-Laure

Background: Hypercalcemia is a well-described paraneoplastic manifestation encountered in a variety of malignancies. However, it is rarely the initial feature of a neuroendocrine tumor.Herein we report a caseof metastatic pancreatic neuroendocrine tumor (NET)presenting with a refractory hypercalcemia and initially misdiagnosed as an adenocarcinoma of the pancreas.Objective: The aim of this case report is to illustratesome of thecom...

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ea0070aep164 | Bone and Calcium | ECE2020

Increasing incidence of parathyroid carcinoma according to russian registry of the primary hyperparathyroidism

Krupinova Julia , Veretennikova Julia , Maganeva Irina , Eremkina Anna , Aynetdinova Alina , Mirnaya Svetlana , Mokrysheva Natalia

Introduction: Parathyroid carcinoma (PC) occurs in 0.005% of all malignant tumors and in less than 1% in primary hyperparathyroidism (PHPT), but recent reports indicate increasing incidence of PC.Aim: To estimate the prevalence of PC in Russia and to identify its distinctive characteristics relevant as preoperative markers.Material and methods: We conducted a retrospective study based on the online Russian Registry of 3061 patients...

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ea0070aep165 | Bone and Calcium | ECE2020

Primary hyperparathyroidism in multiple endocrine neoplasia type 1 (MEN-1) according to the online russian registry

Eremkina Anna , Mirnaya Svetlana , Maganeva Irina , Ajnetdinova Alina , Mokrysheva Natalia

Objective: Primary hyperparathyroidism (PHPT) is one of the most frequently diagnosed endocrine disorders. The Russian Registry of PHPT is an on-line web-based database with the aim to estimate the prevalence and main features of disease. PHPT in Multiple Endocrine Neoplasia type 1 (MEN-1) is associated with polyglandular and early involvement of parathyroid glands.Material and Methods: The database from The Russian Registry of PHPT was used for retrospe...

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ea0070aep166 | Bone and Calcium | ECE2020

Neural network algorithm to determine the optimal range of PTH level for patients with end-stage chronic kidney disease to maintain bone metabolism

Karlovich Natalia , Spiridonova Olga , Mokhort Tatiana

Secondary hyperparathyroidism is highly prevalent in patients with end-stage chronic kidney disease (CKD). Optimal range of PTH level for this cohort of patients is still controversial. The aim of the study was to use a neural network algorithm to determine the optimal point value and confidence interval for the average PTH value for patients with end-stage chronic kidney disease to maintain bone metabolism.The study included 190 patients with end-stage ...

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ea0070aep167 | Bone and Calcium | ECE2020

The trabecular bone score predicts vertebral fragility fractures and decrease in volumetric bone mineral density in postmenopausal women

Kim Keunyoung , Kim Injoo , Pak Kyoungjune , Kim Eunheui , Kyung Jeon Yun

Background: Osteoporosis frequently occurs in elderly people and is commonly associated with fall and fractures which leads the increase of morbidity and mortality. Therefore, precise prediction of osteoporotic fracture is important in clinical setting. The objective of this study was to investigate the association between baseline compression fracture and trabecular bone score (TBS) and was to assess the ability of TBS to predict vertebral fragility fracture and changes of vo...

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ea0070aep168 | Bone and Calcium | ECE2020

Inactivation of diabetoporosity-associated miRNAs in human mesenchymal stem cells

Fößl Ines , Haudum Christoph , Trummer Olivia , Dobnig Harald , Fahrleitner-Pammer Astrid , Kassem Moustapha , Obermayer-Pietsch Barbara , van de Peppel Jeroen

Introduction: Osteoporosis is a disease characterized by the loss of bone density and deficits in bone microarchitecture. “Diabetoporosity” is a new term for osteoporosis in diabetes mellitus type 2 (T2DM) patients, where classical tools for the assessment of bone properties like dual x-ray absorptiometry or bone turnover markers are lacking prognostic accuracy for the determination of bone quality and fracture risk.MicroRNAs (miRNAs) are get...

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ea0070aep169 | Bone and Calcium | ECE2020

Fracture risk in patients with acute poliomyelitis‏ going through late adulthood

Mamlok Sherf Rutie , Cantrell Dror , Or Keren , Marcus Efrat , Benbassat Carlos , Ish Shalom Sofia , Shapira Alex , Koren Ronit

Objective: While osteoporotic fractures are reported in up to 40% of post-poliomyelitis adults, clinical guidelines regarding bone mineral density (BMD) testing and best timing for initiating treatment in this population are scarce. We assessed the characteristics of post-poliomyelitis patients, focusing on fracture and osteoporosis as the primary outcomes.Methods: We conducted a cross-sectional retrospective data analysis from medical records of 204 pos...

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ea0070aep170 | Bone and Calcium | ECE2020

Long term effect on trabecular bone score but not BMD is preserved in GH-deficient adults only when sufficient vitamin D levels are maintained

Kužma Martin , Smaha Juraj , Stojkovičová Daša , Jackuliak Peter , Killinger Zdenko , Payer Juraj

Introduction: Adult growth hormone deficiency (AGHD) is associated with lower bone mass and likely with increased risk of fragility fractures. GH replacement leads to increase in bone mineral density (BMD) and trabecular bone score (TBS). The effect of adequate levels of vitamin D during GH replacement is important to provide effect on TBS.Aim: To assess long–term effectof recombinant GH replacement on BMD and TBS with regards to vitamin D levels d...

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ea0070aep171 | Bone and Calcium | ECE2020

Does real-life time spent within the therapeutic range affect degree of improvement in bone mineral density in men receiving testosterone therapy for hypogonadism?

Osei-Osafo Stephen , Sharma Dushyant , Beeharry Deepa

Background: Hypogonadism in males is associated with a reduction in bone mineral density (BMD). It is known that the reversal of this is achievable through adequate hormone replacement; however, the degree to which this is dependent on the proportion of time patients spend within the recommended therapeutic range (>15 nmol/l) in real-ife has not yet been established.Aim: To evaluate the degree to which the proportion of time that a hypogonadal p...

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ea0070aep172 | Bone and Calcium | ECE2020

Primary hyperparathyroidism diagnosis with 18-F-fluorodioline Pet/CT (FCPCT) in a routine endocrinology praxis: Need of the new guidelines

Schroeder Luc , Smorodova Svetlana , Meilinger Stefan , Münks Sven , Yaneva Maria , Doat Michel , Jonard Florence , Picard Christian , Tikhomirova Maria

Background: Primary hyperparathyroidism (pHPT) is a common disease in a routine endocrinology praxis, but the biggest challenge is a localization of the adenoma and the further correct management of the disease. First FCPCT was reported in 2014 as the additional method of diagnosis of pHPT and in some centers has been already used as a first line diagnostic modality. However, FCPCT is still lacking in the European or International guidelines for the diagnosis of pHPT.<p cl...

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ea0070aep173 | Bone and Calcium | ECE2020

Quality of life, depressin and anxiety in patients with hypoparathyroidism

Anaforoglu İnan , Sancak Seda , Murat Akbas Emin , Oruk Gonca , Canat Masum , Aydın Kadriye , Alphan Uc Ziynet , Gorar Suheyla , Cavlak Gulhan , Eren Guzin , Yılmaz Merve , Ekiz Bilir Betul , Bozoglan Humeyra , Akbaba Gulhan , Muslum Tuna Mazhar , Akcay Seckin , Tuzun Dilek , Simsek Bagir Gulay , Eksi Haydardedeoglu Filiz , Yorulmaz Goknur

Patients with hypoparathyroidism may have sypmptoms consistent with physical, emotional and cognitive dysfunctions which may cause impaired quality of life (QOL). We included 266 patients (20–79 years; 231 women/35 men) who were being treated for hypoparathyroidism. They were taking conventional therapies for hypoparathyroidism; calcium, active vitamin D and magnesium when needed. We applied Beck Depression Scale, Anxiety Scale and SF-36 QOL scale to the patients. The et...

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ea0070aep174 | Bone and Calcium | ECE2020

Colour doppler ultrasound: Preoperative location of parathyroid adenomas in primary hyperparathyroidism

Amaral Sara , Rego Teresa , Vasques Miguel , Gutu Olga , Cláudia Martins Ana , Palha Ana , Sabino Teresa , Cortez Luísa , Afonso António , Fonseca Fernando , Carrilho Nuno , Mário Coutinho José , Tavares Paula , Agapito Ana

Introduction: Parathyroid adenoma is the most frequent cause of primary hyperparathyroidism (PHPT). In recent years minimally invasive surgical techniques have challenged the traditional bilateral neck exploration. There are different imaging techniques for preoperative location of parathyroid adenomas. In this study the authors review the role of Doppler ultrasound focusing on its safety, availability and affordability.Aim: To evaluate the role of Doppl...

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ea0070aep175 | Bone and Calcium | ECE2020

Normocalcemic primary hyperparathyroidism in patients with elevated parathormone (PTH) in a regional health area. A laboratory based approach.

Santana Borja , Alberto Vázquez Luis , Alio Lavín Gómez Bernardo , Pesquera Carlos , Piedra María , García-Unzueta María Teresa

Normocalcemic primary hyperparathyroidism (nPHPT) is still a poorly understood entity, characterized by increased circulating parathormone (PTH) and normal total and ionic calcium, excluding secondary causes.Aim: To characterize the cases of nPHPT detected for a whole year from laboratory records of PTH in a tertiary referral centre, with the purpose of assessing a preliminary estimation and describing their main features.Material ...

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ea0070aep176 | Bone and Calcium | ECE2020

NGS sequencing proves as a powerful method to perform differential diagnosis in patients with inactivating PTH/PTHrP signaling disorders (iPPSD)

Marta Elli Francesca , Antonia Maffini Maria , Costanza Jole , Fontana Laura , Arosio Maura , Mantovani Giovanna

The impairment of the parathyroid hormone (PTH) signaling pathway determines a group of related and highly heterogeneous disorders associated or not with the Albright’s hereditary osteodystrophy (AHO) phenotype, classified as inactivating PTH/PTHrP signaling disorder (iPPSD). iPPSD features are rather difficult to be identified in some casesbecause manifestations are somewhat variable and some AHO characteristics are not specific to a specific disorder. Actually, besides...

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ea0070aep177 | Bone and Calcium | ECE2020

Incidence of hypercalcemia and its causes in spain in a fifteen years period (2001–2015)

Ropero-Luis Guillermo , Sanz-Cánovas Jaime , López-Sampalo Almudena , Gómez-Huelgas Ricardo , Ruiz-Cantero Alberto

Background and aims: Hypercalcemia is a rare ionic disorder and is often overlooked. The aim of this study was to describe the annual incidence of hypercalcemia in the adult population in Spain during a period of fifteen years, using the International Classification of Diseases, 9th Revision Clinical Modification (ICD-9). The diseases and procedures associated with this condition were also assessed.Materials and methods: Data from the Minimum Basic Data ...

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ea0070aep178 | Bone and Calcium | ECE2020

Management of severe hypercalcemia secondary to primary hyperparathyroidism: The efficiency of saline hydration, furosemide, and bisphosphonates.

Mellassi Seifeddine , Oueslati Ibtissem , Belaid Rym , Khessairi Nadia , Yazidi Meriem , Grira Wafa , Chaker Fatma , Chihaoui Melika

Introduction: Severe hypercalcemia is a life-threatening condition which should be managed urgently. Its pharmacological treatment consists of intravenous saline hydration, loop diuretic and intravenous administration of bisphosphonates. However, data evaluating these treatments are very limited.The aim of this study was to assess the efficiency of saline hydration, furosemide, and bisphosphonates in the management of severe hypercalcemia secondary to a ...

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ea0070aep179 | Bone and Calcium | ECE2020

Modeling to estimate the prevalence of chronic hypoparathyroidism in the absence of population-based studies

Ayodele Olulade , Zhang Nicole

Hypoparathyroidism is a rare endocrine disorder characterized by insufficient parathyroid hormone levels in the blood, low serum calcium and elevated serum phosphate. Studies evaluating the prevalence of chronic hypoparathyroidism (cHypoPT) are limited, and it is challenging to compare prevalence estimates owing tothe rarity of the disease and the difficulty of differentiating transient from permanent or cHypoPTin secondary data analyses. PublishedcHypoPTprevalence is between ...

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ea0070aep180 | Bone and Calcium | ECE2020

Baseline characteristics from the observational paradighm registry of patients with chronic hypoparathyroidism

L Clarke Bart , Rejnmark Lars , Ing Steven , Luisa Brandi Maria , Björnsdottir Sigridur , Hahner Stefanie , Hofbauer Lorenz C , Houillier Pascal , Khan Aliya A , Levine Michael A , Mannstadt Michael , M Shoback Dolores , Vokes Tamara J , Zhang Pinggao , Marelli Claudio , Germak John , Gittoes Neil

PARADIGHM is an actively recruiting, prospective, observational registry (NCT01922440/EUPAS16927). The primary objective is to evaluate the safety and effectiveness of recombinant human parathyroid hormone, rhPTH(1-84), treatment in patients with chronic hypoparathyroidism under routine clinical care. The secondary objective is tocharacterize the clinical course of chronic hypoparathyroidism under conditions of routine clinical practice. At enrollment, registry inclusion crite...

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ea0070aep181 | Bone and Calcium | ECE2020

Clinical presentations of patients receiving PTH-therapy among the referral population with hypoparathyroidism.

Gronskaia Sofia , Grebennikova Tatiana , Pigarova Ekaterina , Rozhinskaya Luidmila , Melnichenko Galina , Luiza Brandi Maria , Belaya Zhanna

This study aims to evaluate patients who require PTH-treatment among the referral population with hypoparathyroidism.Methods: The information was collected from the registry database of chronic hypoparathyroidism, which was initiated by the National Medical Research Centre for Endocrinology (NMRCE).Results: Among 194 cases of hypoparathyroidism referred to our clinic over 2 years (2017–2019), eig...

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ea0070aep182 | Bone and Calcium | ECE2020

Clinical characteristics of subjects with very high serum 25 OH vitamin D levels in turkey: DeVIT-TOX survey

Pekkolay Zafer , Gogas Yavuz Dilek , Sedar Saygili Emre , Topaloğlu Ömercan , Emir Önder Çağatay , Soylu Hikmet , Taskaldiran Isilay , Esen Pazır Ayșe , Ugur Kader , Tanrikulu Seher , Nur Firat Sevde , Meryem Atak Burcu , Batman Adnan , Omma Tülay , Cagiltay Eylem , Ozdemir Kutbay Nilufer , Çetinkaya Altuntaș Seher , Nasiroglu Imga Narin , Karakilic Ersen , Hekimsoy Zeliha , Kılınç Faruk , Yay Adnan , Eroğlu Mustafa , Kemal Tuzcu Alpaslan

Background: Treatment of vitamin D deficiency orinappropriate vitamin D supplementation may cause side effects associated with hypercalcemia. We observed a tendency to use very high single dose cholecalciferol for treatment of vitamin D deficiency.Aim: The primary aim of this study was to examine the clinical characteristics of patientswith very high serum 25OHD levels of vitamin D toxicity in Turkey.Materials and methods: An invit...

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ea0070aep183 | Bone and Calcium | ECE2020

The bone density and trabecular bone score in patients after solid organ transplantation

Brunova Jana , Kratochvilova Simona

Introduction: Organ transplant recipients are at increased fracture risk compared to general population. Bone mineral density (BMD), predictive of fracture in general population, does not reflect impaired bone quality frequently present in patients with advanced organ failure. Trabecular bone score (TBS) provides surrogate measures of bone microarchitecture and therefore helps to identify persons at risk for fracture among transplant recipients.Methods: ...

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ea0070aep184 | Bone and Calcium | ECE2020

Free 25-hydroxyvitamin D, but not free 1.25-dihydroxyvitamin D, predicts all-cause mortality in ageing men

Antonio Leen , Dejaeger Marian , Bouillon Roger , Wu Frederick , O’Neill Terence , Pye Stephen , Huhtaniemi Ilpo , Rastrelli Giulia , Forti Gianni , Casanueva Felipe , Slowikowska-Hilczer Jolanta , Punab Margus , Tournoy Jos , Vanderschueren Dirk

Background: Total 25 hydroxyvitamin D (25(OH)D) and total 1.25 dihydroxyvitamin D (1.25(OH)2D) are associated with all-cause mortality. The free hormone hypothesis postulates that only the free vitamin D fraction can exert its biological function. Recently some studies suggested that free 25(OH)D levels might be a better predictor for clinical outcomes, including mortality.Objective: To study the association between total and free 25(OH)D and ...

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ea0070aep185 | Bone and Calcium | ECE2020

Calcium-sensing receptor gene polymorphisms and their effect on response to cinacalcet treatment in patients with secondary hyperparathyroidism in chronic kidney diseases

Egshatyan Lilit , Filippova Tamara , Nuralieva Sevda , Svetlichnaya Diana , Asanov Aliy , Litvinova Maria

Background: Secondary hyperparathyroidism (SHPT) is an adaptive process that develops in response to declining kidney function, impaired phosphate excretion, and failure to bioactivate vitamin D. The signal transduction via the calcium-sensing receptor (CaSR) is a key determinant of parathyroid gland hyperplasia.Aims: To examine the polymorphisms rs1801725 (p.Ala986Ser, G>T), rs1042636 (p.Arg990Gly, A>G), rs1801726 (p.Glu1021Gln, G>C) of ...

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ea0070aep186 | Bone and Calcium | ECE2020

An extremely rare cause of severe primary hyperparathyroidism due to intrathyroidal parathyroid cyst.

Monroy Sánchez Jorge , Delgado Lucio Ana María , Santos Mazo Estefanía , Baraia-Etxaburu Marta , Herguedas Vela Pablo , Gundin Menéndez Simón , de la Parte Ana Ruiz , Beatriz Palacios Ball Johanna

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia, most cases with parathyroid adenoma as the underlying pathology. However, when blood and urine calcium levels and PTH are higher than normal in PHPT, t’s important to suspect an ectopic PTH secretion or a parathyroid carcinoma. Intrathyroidal parathyroid cysts are extremely rare cause of severe PHPT.Clinical case: A 36-year-old male presented with dizziness ...

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ea0070aep187 | Bone and Calcium | ECE2020

Skeletal manifestations of hypoparathyroidism mimicking ankylosing spondylitis; a rare clinical presentation: A case report

Gunatilake Sonali , Bulugahapitiya Uditha

Introduction: Idiopathic hypoparathyroidism is a rare endocrine disorder with varying clinical manifestations ranging from acute hypocalcemic symptoms to asymptomatic soft and skeletal tissue calcifications/ossifications. Patients may present with wide spectrum of rheumatological manifestations, which are under-recognized, thus delaying timely treatment. This results in chronic disability.Case presentation: A 47-year-old male with past history of convuls...

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ea0070aep188 | Bone and Calcium | ECE2020

Hypercalcemia and primary hyperparathyroidism case progressing during the treatment of dapagliflozin

Akhanli Pinar , Hepsen Sema , Uçan Bekir , Saylam Güleser , Çakal Erman

Introduction: Hypercalcemia associated with the use of a SGLT-2 inhibitor is a very rare adverse effect. Herein we reported a case of apparent primary hyperparathyroidism that occurred while applying the treatment of dapagliflozin in a patient with asymptomatic primary hyperparathyroidism.Case report: A 49-year-old male patient with 5 years of diabetes mellitus history admitted for his routine control and Hba1c level was observed 7.9%. Dapagliflozin (1 &...

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ea0070aep189 | Bone and Calcium | ECE2020

Radioiodine, hyperparathyroidism and schwannoma... coincidence or consequence?

Mammadov Emin , Goldstein Andrei , Vladescu Ruxandra

Background: Primary hyperparathyroidism (PHPTH) refers to overproduction of PTH (parathyroid hormone) which leads to hypercalcaemia and hypophosphataemia. Preoperative imaging aims identification of a solitary parathyroid adenoma (PTA) or multiple gland hyperplasia. However, it is not always possible to identify the lesions, and in some situations imaging findings could be misleading.Case report: A 48-year old male, with personal history of differentiate...

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ea0070aep190 | Bone and Calcium | ECE2020

Multiple endocrinopathies associated with myotonic dystrophy type 1 – case report

Miličević Tanja , Novak Anela

Introduction: Myotonic dystrophy type 1 (DMT1) is the most prevalent muscular dystrophy that affects 1 in 8000 individuals. Disease is caused by CTG repeat expansion of the DMPK gene located on chromosome 19. Beside neuromuscular involvement, studies have found an increased prevalence of endocrinopathies such as diabetes, hyperparathyroidism and hypogonadism. The exact underlying mechanism of endocrine dysfunction remains unclear. Moreover, endocrine dysfunction is progressive...

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ea0070aep191 | Bone and Calcium | ECE2020

Remission of disseminated parathyroid cancer after multiple surgical interventions because of recurrences in the neck lymph nodes, left lung and liver in a young patient with hyperparathyroidism-jaw tumor syndrome

Krupinova Julia , Mokrysheva Natalia

Background: Parathyroid cancer (PC) is a rare tumor associated with poor prognosis particularly when disseminated. Currently, the only effective treatment is a surgical intervention.Case: Starting from the age of 19 a woman had been suffering from bone pains and change in gait. A low-energy right humerus fracture with displacement occurred when she was 23. At the same time, primary hyperparathyroidism (PHPT) was diagnosed for the first time (PTH 569 pg/m...

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ea0070aep192 | Bone and Calcium | ECE2020

Sequencing of the gnas gene in hungarian patients with pseudohypoparathyroidism and mccune-albright syndrome

Nyirő Gábor , Patocs Attila , Igaz Péter

Introduction: The human GNAS gene is coding for the alpha stimulatory subunit of the guanine nucleotide-binding protein. This G protein stimulates the activity of the adenylate cyclase enzyme which is in control of the production of various hormones in endocrine glands and also regulates bone development. Mutations in GNAS can lead to McCune Albright syndrome, progressive osseous heteroplasia or pseudohypoparathyroidism.Aim: Our aim was to find the genet...

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ea0070aep193 | Bone and Calcium | ECE2020

Mineral density of bone tissue, parathyroid hormone and vitamin D in children and adolescents with thyrotoxicosis

Muratova Shakhlo , Alimov Anvar

Thyroid hormones have an important role in bone metabolism. In this case, hyperthyroidism causes secondary osteoporosis and osteopenia. There is very little information in the literature about the state of bone metabolism in children and adolescents with thyrotoxicosis. Thus, our work aimed to study the state of bone mineral density and levels of calciotropic hormones in children and adolescents with thyrotoxicosis. The study was conducted in a group of 19 children and adolesc...

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ea0070aep194 | Bone and Calcium | ECE2020

Assessing risk factors and predictors of mortality in patients with fragility hip fracture

Lima Ferreira Joana , Teixeira e Silva Joana , Simões de Carvalho Francisco , de Brito Marques Francisca , Paula Marques Ana , Maria Príncipe Rosa

Introduction: Fragility fractures are the main consequence of osteoporosis. It results in increased morbidity and mortality. The incidence of fractures has been increasing steadily in Portugal. Hip fragility fractures have been estimated to occur in up to 572/100,000/year in women and up to 232/100,000/year in men.Methods: A retrospective study of hospitalized patients for femoral neck fracture in our institution in 2018 was performed to evaluate their p...

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ea0070aep195 | Bone and Calcium | ECE2020

Bone quality is associated with perinatal nutritional manipulation in adult Wistar rats offspring

Augoulea Areti , Syggelos Nikolaos , Armeni Eleni , Kaparos George , Vafaei Homeira , Dontas Ismene , Marinou Katerina , Vaggos George , Raptou Panagiota , Lambrinoudaki Irene , Eleftheriades Makarios , Nicolaides Kypros H

Introduction: Prenatal and perinatal food manipulation might be related with bone quality in offspring of Wistar rats. This study aimed to assess the impact of different dietary patterns provided before delivery to the mothers on the skeletal characteristics of newborn rats and the levels of insulin.Materials and methods: We randomized 67 timed-pregnant rats into control diet (CD), high-fat (FD) and food-restricted (FR) on the 12th day of gestation. The ...

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ea0070aep196 | Bone and Calcium | ECE2020

Epidemiology of osteoporotic hip fracture in the largest urban area of Romania

Dobre Ramona , Dan Alexandru Niculescu , Catalina Poiana

Background: Osteoporotic hip fracture remains a problem of public health concern. Different studies highlighted the existence of a particular epidemiology derived from local differences. We aimed to evaluate the epidemiology of osteoporotic hip fracture in the capital city of Romania plus city suburban area.Methods: We collected data from over 95 % of fractures from hospitals with an Orthopedic Surgery Department in the area of interest. Patients were se...

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ea0070aep197 | Bone and Calcium | ECE2020

The osteoporosis and hormonal status of our thalassemia patients

Dağdelen Duran Iffet , Ersöz Gülçelik Neșe

Introduction: Thalassemia manifests clinically as anemia requiring life-long blood transfusions and the chronic iron deposition . Iron overload can lead to decreased functioning of the respective systems. Thalassemia-associated osteoporosis constitutes a majorproblem. Weinvestigated the bone mineral density scores of the thalassemic patients and correlated the scores of themwith some parameters including the transfusion frequency, levels of ferritin and pituitary hormones....

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ea0070aep198 | Bone and Calcium | ECE2020

Follow-up report: A case of FGF23-related tumor-induced osteomalacia with pulmonary adenocarcinoma

Arai Hiroshi , Kanai Yugo , Nakamoto Yuji , Sakamori Yuichi , Yamauchi Ichiro , Fujii Toshihito , Taura Daisuke , Sone Masakatsu , Yasoda Akihiro , Inagaki Nobuya

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by the abnormal production of fibroblast growth factor 23 (FGF23) in the tumor. We havereported a case of TIO with pulmonary adenocarcinoma at ECE2018. Here we present the follow-up report of the case. A 61-year old woman suffering from severe polyarthralgia and bilateral limb weakness was referred to our hospital. Her blood chemistry revealed high alkaline phosphatase, low phosphate, low calcium, and lo...

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ea0070aep199 | Bone and Calcium | ECE2020

Biochemical and clinical findings distinguishing between the genetic and the acquired conditions in osteoporotic patients with low serum alkaline phosphatase levels

Sileo Federica , Guarnieri Vito , Indirli Rita , Guabello Gregorio , Longhi Matteo , Dito Giorgia , Corbetta Sabrina

Background: Hypophosphatasia is a rare genetic disease with low serum alkaline phosphatase (ALP) activity and hypophosphatasemia. It is caused by loss-of-function mutations and deletions of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) gene; it has a wide range of severity in its phenotype, from death in utero to asymptomatic disease accidentally diagnosed in adult life. Furthermore, some diseases and drugs may induce hypophosphatasemia. Thus, the ...

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ea0070aep200 | Bone and Calcium | ECE2020

Multiple vertebral fractures in a real-life denosumab-treated cohort: Patient level data

Tripto-Shkolnik Liana , Yekutiel Naama , Chodick Gabriel , Shalev Varda , Goldshtein Inbal

Introduction: Denosumab discontinuation rapidly reverses bone turnover inhibition and eliminates anti-fracture protection. Multiple vertebral fractures (MVF) were reported in this scenario. Previously, we reported a retrospective real-life analysis designed to estimate fracture risk following denosumab discontinuation. Here we report a patient-level data of a subgroup with MVF.Methods: Via computerized database of Maccabi Healthcare Services, persistent ...

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ea0070aep201 | Bone and Calcium | ECE2020

Body composition and bone mineral density in craniopharyngioma patients: A longitudinal study over 10 years

Van Santen Selvetta S , Olsson Daniel S , Hammarstrand Casper , Wijnen Mark , Fiocco Marta , van den Heuvel-Eibrink Marry M , Johannsson Gudmundur , Van der Lely Aart Jan , Neggers Sebastian

Introduction: Patients with craniopharyngioma (CP) suffer from pituitary deficiencies and hypothalamic damage, resulting in obesity and impaired bone health. Little is known about long-term changes in body composition and bone mineral density (BMD).Methods: Dutch and Swedish patients were included in this retrospective longitudinal study if they had DXA-scan (body composition/BMD) data available at age of 18 years or older. Linear regression modelswerees...

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ea0070aep202 | Bone and Calcium | ECE2020

Body composition and adipokines influence upon bone mineral density and bone metabolism in renal transplant receivers

Matei Anca , Bilha Stefana , Constantinescu Daniela , Cianga Petru , Covic Adrian , Branisteanu Dumitru

Introduction: Renal transplant receivers (RTR) have a higher risk for osteoporosis, obesity and sarcopenia, which all seem to be interrelated. FGF23 and adipokine disorders, often recognized in RTR, might be involved in the fat-muscle-bone crosstalk. The current study aims to evaluate the influence of body compartiments and adipokines on bone mass in RTR.Methods: Thiscross-sectional study investigates the predictive role of body composition, adipokines (...

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ea0070aep203 | Bone and Calcium | ECE2020

Hip spine discordance in bone mineral density: Prevalence and potential significance

Balachandran Karthik , Mahadevan Shriraam , Reena Asirvatham Adlyne

Introduction: The WHO recommends that osteoporosis be diagnosed based on the lowest T score in hip, spine or distal 33% radius. Indian guidelines emphasize T score based diagnosis and treatment of osteoporosis..One of the reasons for measuring bone density is to account for differences in bone density between sites. The data on discordance in bone density between the hip, spine and distal radius is scarce in India - despite DXA scanning being available in India for the last 20...

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ea0070aep204 | Bone and Calcium | ECE2020

High serum FSH is not a risk factor for low bone mineral density in infertile men

Antonio Leen , Priskorn Lærke , Olesen Inge A , Vanderschueren Dirk , Joergensen Niels

Background: Male infertility is associated with a higher long-term morbidity and mortality risk. However, it is not clear which diseases are contributing to this risk. Osteoporosis is a possible factor, as it is a frequent disease and sex steroids regulate both fertility and bone health. Furthermore, there are data indicating that high FSH levels in women are related to low bone mineral density (BMD), independent of estradiol levels. As infertile men often have increased FSH, ...

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ea0070aep205 | Bone and Calcium | ECE2020

Denosumab-induced hypocalcemia: Does gender play a role?

Diker-Cohen Talia , Amitai Oren , Shochat Tzippy , Shimon Ilan , Tsvetov Gloria

Introduction: The recognition that disease presentation, treatment and outcomes may differ betweenmen and women has become established. We have recently reported a-7.4% rate of denosumab-associated hypocalcemia in community-dwelling osteoporotic patients.Aim: To investigate the role of gender in this complication.Methods: A retrospective analysis of medical records (2010–2018) from a large HMO. An albumin-adjusted serum calci...

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ea0070aep206 | Bone and Calcium | ECE2020

Parathyroid carcinoma: An italian multicenter retrospective analysis

Gianotti Laura , Castellano Elena , Lauro Corrado , Piovesan Alessandro , Procopio Massimo , Barale Marco , Palestini Nicola , Quaglino Francesco , Manfrino Luca , Bullara Valentina , Volante Marco , Borretta Giorgio

Parathyroid carcinoma (PC) is a rare neoplasia responsible for about 1% of primary hyperparathyroidism (PHPT). Differently from patients with its benign counterpart, the phenotype of these patients is characterized by severe PHPT and hypercalcemia. The aim of this study was to describe a series of PC casesrecorded in the regional cancer network of Piedmont and Valle d’Aosta, Italy (Rete Oncologica del Piemonte e della Valle d’Aosta) from 2007 to 2017, including 25 ...

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ea0070aep207 | Bone and Calcium | ECE2020

18Fluoro-choline PET/CT is a useful tool for patients with primary hyperparathyroidism negative at first-line imaging localization tecniques

Apicella Matteo , Bola Stefano , Volterrani Duccio , Mazoni Laura , Frustaci Gianluca , Materazzi Gabriele , Marcocci Claudio , Cetani Filomena

Primary hyperparathyroidism (PHPT) is a common endocrine disease mainly caused by a single parathyroid adenoma. Although the localization of the parathyroid adenoma is not a surgical criteria for parathyroidectomy, this is known to increase the cure rate of PHPT and reduce the complication rate. Neck ultrasound and MIBI-scintigraphy are the first-line localization techniques to detect parathyroid adenomas, however, they have some limitations including the operator-dependent se...

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ea0070aep208 | Bone and Calcium | ECE2020

Effect of vitamin D supplementation on carotid intima media thickness in overweight and obese schoolchildren: A single blind randomized clinical trial

Asghari Golaleh , Yuzbashian Emad , Wagner Carol , Mirmiran Parvin , Hosseinpanah Farhad

Previous observational studies suggest that low 25(OH)D concentrations in childhoodmight have deleterious effects on vasculature. The present study addresses this key knowledge gap with the use of a dose-response randomized clinical trial (RCT) aimed to determine the effect ofone-year vitamin D supplementationon carotid intima media thickness (cIMT) in overweight and obese school children. The current study was a single-blind RCT. A total of 378 children and adolescents, 6&#82...

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ea0070aep209 | Bone and Calcium | ECE2020

Can serum calcium, phosphorus and parathyroid hormone levels predict histopathological diagnosis in patients with primary hyperparathyroidism?

Dirikoc Ahmet , Baser Husniye , Neslihan Cuhaci Seyrek Fatma , Polat Burcak , Ögmen Berna , Ali Tam Abbas , Aydın Cevdet , Kilic Yazgan Aylin , Kilic Mehmet , Ozdemir Didem , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Aim: While the histopathological diagnosis is parathyroid adenoma in majority of patients with primary hyperparathyroidism (PHPT),parathyroid hyperplasia, atypical parathyroid adenoma or parathyroid carcinoma can be seen in others. Although it is known that serum calcium (Ca) and parathyroid hormone (PTH) levels are higher in patients with parathyroid carcinoma, there are not any cut-off value for serum Ca, phosphorus (P) and PTH levels defined for different histopathological ...

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ea0070aep210 | Bone and Calcium | ECE2020

Is the assessment of clinical risk factors for vitamin D deficiency sufficient?

Pigarova Ekaterina , Vorotnikova Svetlana , Korolenko Andrey , Dzeranova Larisa , Rozhinskaya Liudmila

Introduction: Extremely low levels of vitamin D usually include levels < 4 ng/ml, which is almost the same as undetectable. The risk groups for vitamin D deficiency have been identified, but do they allow such patients to be identified based solely on clinical presentation.Objective: To identify risk factors and their actual clinical determination in patients with 25(OH)D serum levels <4 ng/ml.Materials and methods: The stu...

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ea0070aep211 | Bone and Calcium | ECE2020

First results of an austrian prospective hypoparathyroidism registry – the HypAus study

Schatzl Stefan , Tmava Adelina , Scherkl Mario , Kaser Susanne , Fahrleitner-Pammer Astrid , Mader Julia , Zach Maximilian , Amrein Karin

Background: Permanent hypoparathyroidism is the most common complication of thyroid surgery with a reported incidence of 2-10% depending on the observation time, extent of surgery and underlying disease, with higher risk for total thyroidectomy and Graves disease/thyroid cancer. European data on chronic hypoparathyroidism have been reported from several countries, especially Scandinavia. We therefore aimed to add more information from Central Europe.Meth...

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ea0070aep212 | Bone and Calcium | ECE2020

Renal complications in patients with chronic hypoparathyroidism receiving conventional therapy: A systematic literature review

Gosmanova Elvira , Houillier Pascal , Bilezikian John , Marelli Claudio , Rejnmark Lars

Conventional therapy for chronic hypoparathyroidism is oral calcium and active vitamin D; despite treatment, chronic hypoparathyroidism may be associated with increased risk of renal complications. Without the effect of parathyroid hormone on renal tubular reabsorption, calcium-conserving and phosphaturic effects are lost, serum calcium levels are reduced and serum phosphate levels are increased. This may lead to hypercalciuria and hyperphosphataemia, which may be associated w...

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ea0070aep213 | Bone and Calcium | ECE2020

Renin-angiotensin-aldosterone system in patients with primary hyperparathyroidism

Dobreva Ekaterina , Bibik Ekaterina , Eremkina Anna , Krupinova Julia , Mirnaya Svetlana , Ajnetdinova Alina , Mokrysheva Natalia

Background: Hypertension is one of the widespread cardiovascular pathology in patients with primary hyperparathyroidism (PHPT).The renin-angiotensin-aldosterone system (RAAS) is a key system in the regulation of blood pressure and its interactions with mineral metabolism are described. Our previous study* of PHPT patients revealed a significant decrease in plasma renin activity (PRA) and serum aldosterone levels in the early postoperative period and also positive correlations ...

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ea0070aep214 | Bone and Calcium | ECE2020

Gene expression of claudins in NCKX3 knockout mouse

Myeong Go Seon , Yi Donglin , Lee Jae-Hwan , Yoo Yeong-Min , Jeung Eui-Bae

Potassium-dependent sodium/calcium exchanger (NCKX3) is expressed in the brain, smooth muscle, the uterus, and intestine. NCKX3 gene plays a role in transporting intracellular calcium and potassium ions across the cell membrane in exchange for extracellular sodium ions. This gene is also associated with calcium metabolism in bones. Tight junctions have functional barriers for material transport and osmotic balance, which are regulated by calcium metabolism. Claudin, o...

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ea0070aep215 | Bone and Calcium | ECE2020

Progression of vertebral fractures in long-term controlled acromegaly: A 9-year follow-up study

Pelsma Iris , Claessen Kim , Pereira Alberto , van Furth Wouter , Appelman-Dijkstra Natasha , Kloppenburg Margreet , Kroon Herman , Biermasz Nienke

Objective: Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) excess results in both reversible and irreversible damage to the skeleton, and includes increased vertebral fracture (VF) risk in the presence of normal BMD. The prevalence of VFs is approximately 60% in controlled acromegaly patients, and these VFs can progress during short-term follow-up. We aimed to identify the course of VFs and their associated risk factors in a cohort of acromegaly patients in long-t...

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ea0070aep216 | Bone and Calcium | ECE2020

Assessment of physical fitness after bariatric surgery and its association with protein intake and type of cholecalciferol supplementation

Smelt Hendrika , Pouwels Sjaak , Celik Alper , Gupta Adarsh , Smulders Johannes

Background: Several studies showed that there is a relationship between vitamin and mineral status and muscle strength. In particular this is the case for handgrip strength (HS) and vitamin D deficiency. In bariatric surgery there is a risk of decrease in muscle strength after surgery and also vitamin and mineral deficiencies are not uncommon. The aim of this study is to assess the effect of low vitamin 25 (OH) cholecalciferol levels, high dose cholecalciferol supplementation ...

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ea0070aep217 | Bone and Calcium | ECE2020

The Burden of chronic hypoparathyroidism in canada: A retrospective study using the institute for clinical evaluative sciences (ices) database

A Khan Aliya , Chen Kristina , Marelli Claudio , Demchyshyn Lidia

Hypoparathyroidism is a rare disorder characterised by hypocalcaemia and hyperphosphataemia in the presence of low or inappropriately normal parathyroid hormone levels. Currently there are limited data on the burden of illness and healthcare resource utilisation (HCRU) associated with chronic hypoparathyroidism in Canada. A retrospective cohort analysis with matched controls was conducted to examine HCRU in patients with chronic hypoparathyroidism in Ontario, Canada. Data were...

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ea0070aep218 | Bone and Calcium | ECE2020

Cinacalcet use in pregnancy for a case of multiple endocrine neoplasia (MEN) 1 - associated primary hyperparathyroidism

Mashamba Chiedza , Essilfie Papa , Kumar Mohit

Hypercalcaemia in pregnancy is associated with foetal (IUGR, miscarriage and preterm delivery), maternal (hypercalcaemic crisis, pre-eclampsia, and hyperemesis) and neonatal complications, with severity of hypercalcaemia correlating with the risk of complications. The true incidence of primary hyperparathyroidism in pregnancy is unknown.A 32 year old lady (G6 P5) with known MEN 1 and associated primary hyperparathyroidism (peak calcium 3.30 mmol/l) ...

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ea0070aep219 | Bone and Calcium | ECE2020

An enlarged parathyroid gland emerging in the bed of the thyroid may mimic local recurrence in patients after total thyroidectomy for the papillary thyroid cancer: How does recovery from postsurgical hypoparathyroidism work?

Godlewska Paulina , Długosińska Joanna , Bakuła-Zalewska Elwira , Chojnowski Marek , Dedecjus Marek

Anatomical proximity, common blood supply and variability of location of the parathyroid glands make them prone to damage in the course of thyroid gland surgery. Total thyroidectomy (TT) poses a greater risk of postsurgical hypoparathyroidism (hypoPT) than a unilateral lobectomy, and neck lymph nodes dissection is an established risk factor of HypoPT. HypoPT lasting longer than 6–12 months postoperatively is considered permanent. The mechanism responsible for the recover...

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ea0070aep220 | Bone and Calcium | ECE2020

Fahr’s disease in primary hypoparathyroidism – a case report

Haxhiraj Adela , Hoxha Violeta , Husi Gerond , Kermaj Marjeta , Ylli Agron

Introduction: Basal ganglia calcification or Fahr’s Syndrome is a rare form of neurological disorder. Its prevalence goes from 2 to 12.5 %. It can be primary (idiopathic) or secondary (from metabolic disorders especially from hypoparathyroidism).We present the case of a female patient with hypoparathyroidism and secondary Fahr’s Disease.Case description: The patient L.J. 61 years old, from Pogradec, Albania, who came to the emergency room wit...

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ea0070aep221 | Bone and Calcium | ECE2020

Varied clinical presentation of pseudohypoparathyroidism- series of three distinctive cases

Phatale Hemant , Phatale Priti

Introduction: Pseudohypoparathyroidism (PHP) is a state of parathyroid hormone resistance and is characterised by low serum calciumand elevated serum phosphate and parathyroid hormone levelCase descriptions: We describe three cases diagnosed with PHP. Case 1: 14 year old male, known case of hypothyroidism, presented with carpopedal spasm and on treatment with 75 mg oflevothyroxine, with short height of 143 cm (less than 3rd percentile), BMI 23.2...

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ea0070aep222 | Bone and Calcium | ECE2020

Testosterone, estradiol and 25-hydroxyvitamin D effects at the proximal femur in 3D analysis from a standard 2D DXA scans of adult men

Rui Mascarenhas Mário , Barbosa Ana Paula , Winzenrieth Renaud

Sex steroid hormones play a pleomorphic role in preservation of BMD. The BMD, the blood circulating 25-hydroxyvitamin D [25(OH)D], testosterone and estradiol levels may decline with age and to contribute to bone fragility. Low vitamin D is associated with increased falls number and fractures.Recently, a new software solution, 3D-SHAPER - allows measurements of both trabecular and cortical bone as well as 3D images -, it incorporates a model-bas...

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ea0070aep223 | Bone and Calcium | ECE2020

Trabecular bone score assessment in heart transplant recipients stratified by time after transplantation

Rakusa Matej , Janez Andrej , Jensterle Mojca

Objective: Bone strength post heart transplant (HT) is affected by many factors including glucocorticoids, calcineurin inhibitors, hypogonadism, vitamin D deficiency, secondary hyperparathyroidism and cachexia. Trabecular bone score (TBS), novel texture index derived from lumbar spinal DXA improves fracture risk assessment in several different high-risk populations, whereas it remains largely understudied in HT recipients. We aimed to evaluate factors that affect TBS after HT....

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ea0070aep224 | Bone and Calcium | ECE2020

Efficacy of teriparatid therapy in resistant hypocalcemia depending postoperative hypoparathyroidism

Durmuș Buğra , Karaahmetli Gülsüm , Keskin Müge , Tural Balsak Belma , Bașer Hüsniye , Berker Dilek

Objective: While postoperative hypoparathyroidism can usually be controlled with elemental calcium (Ca) and calcitriol therapy, rarely this treatment may be inadequate and teriparatid therapy may be used as an alternative. In the literature, it is reported that teriparatid therapy is effective and reliable in the treatment of patients with postoperative hypoparathyroidism, as well as improving quality of life and reducing the frequency of hospitalization. In this report, we pr...

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ea0070aep225 | Bone and Calcium | ECE2020

Trabecular bone score in postmenopausal women with primary hyperparathyroidism

Bohdanowicz-Pawlak Anna , Szymczak Jadwiga , Jędrzejuk Diana

Introduction: Primary hyperparathyroidism (PHPT) is generally associated with increased fracture risk at all skeletal sites although greater bone loss is observed at the cortical than the trabecular bone sites. AsBMD alone does not adequately predict fracture risk, trabecular bone score (TBS) is proposed as a new method supporting risk assessment.The aim of this study was to investigate correlation between TBS andthe severity of primary hyperparathyroidi...

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ea0070aep226 | Bone and Calcium | ECE2020

The incidence of nephrolithiasis and osteoporosis in patients with asymptomatic hyperparathyroidism

Polymeris Antonis , Kalogeris Nikolaos , Lafkas Apostolos , Papanikola Nektaria , Herolidi Eleni , Kogia Christina , Vryonidou Andromahi

Introduction: The clinical profile of patients with primary hyperparathyroidism has changed significantly in the last decades considering the fact that most cases are asymptomatic. This could be attributed to early diagnosis due to routinely serum calcium measurement. Only 5–27% of patients present with symptoms or signs related to osteoporosis, nephrolithiasis and hypercalcaemia. However, in patients with asymptomatic primary hyperparathyroidism (APHP) data concerning t...

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ea0070aep227 | Bone and Calcium | ECE2020

Osteogenesis imperfecta type V due to a rare mutation c.119C> T in the IFITM5: A case report

Grebennikova Tatiana , Gavrilova Alina , Tiulpakov Anatoly , Tarbaeva Natalia , Melnichenko Galina , Belaya Zhanna

Osteogenesis imperfecta (OI) is a heritable skeletal disorder caused by defective bone formation. OI type V (MIM#:614757) develops due to mutation in the IFITM. Mutation c.-14C >T in the IFITM5 is more common whereas only five reported patientshave a c.119C >T mutation. Patients with IFITM5:c.119C >T mutation usually have low-traumatic fractures in the prenatal period of development, severe limb and chest deformities, short height, verteb...

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ea0070aep228 | Bone and Calcium | ECE2020

A case of severe asymptomatic hypercalcaemia in IgG kappa multiple myeloma, focal bone disease and inappropriately normal PTH as a differential diagnostic dilemma

Manova Yuliya , Rabin Neil , Baldeweg Stephanie

We present the case of 63 years old female patient who was diagnosed with IG G kappa multiple myeloma in 2007. Cytogenetics investigations revealed high risk for progression of the disease (cytogenetics: 17 p deletion and t (4/14). The patient decided against active treatment. Over 10 years she was kept under observation with no symptoms. Her basal paraprotein levels slowly progressed from 14 g/l up to 18 g/l. In 2017 she developed mild hypercalcaemia (corrected calcium 2.72 m...

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ea0070aep229 | Bone and Calcium | ECE2020

Trabecular bone score in subjects after simultaneous pancreas kidney transplantation

Kratochvílová Simona , Brunová Jana , Saudek František

Introduction: Osteoporosis is a well known long-term complication after simultaneous pancreas kidney transplantation (SPK). Alterations of bone microstructure contribute to the risk of fracture and trabecular bone score (TBS) measurement offers and additional tool to quantify bone microarchitecture impairment.Methods: There were 33 subjects with type 1 diabetes mellitus (23 men, 10 women, mean age 43.4 ± 9.8 years) participating in a prospective obs...

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ea0070aep230 | Bone and Calcium | ECE2020

Vertebral fractures in patients with castration-resistant prostate cancer undergoing treatment with Radium-223: A longitudinal study in the real-life clinical practice.

Mazziotti Gherardo , Rodari Marcello , Pepe Giovanna , Gelardi Fabrizia , Zucali Paolo , Chiti Arturo

Radium-223 was associated with high incidence of non-vertebral fractures in patients with castration-resistant prostate cancer (CRPC). The determinants of this effect are unknown and it is still unclear whether Radium-223 may induce skeletal fragility regardless of other therapies of CRPC. We aimed at evaluating the incidence and determinants of vertebral fractures (VFs), i.e. the hallmark of skeletal fragility, in CRCP patients undergoing Radium-223 therapy in the real-life c...

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ea0070aep231 | Bone and Calcium | ECE2020

A follow-up of a patient with osteopetrosis successfully treated with bone marrow transplant at the age of 28

Zhilyaev Viktor , Belaya Zhanna , Arapova Svetlana , Mamedova Elizaveta , Natalia Tarbaeva

Introduction: Osteopetrosis is a rare hereditary disease caused by defective osteoclast differentiation or function. Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for some forms of osteopetrosis. HSCT is usually performed in infancy. Currently there is also experience of HSCT for osteopetrosis in adults1. In this clinical case we describe the follow-up of a patient treated with HSCT1 at the age of 28.<p class="abst...

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ea0070aep232 | Bone and Calcium | ECE2020

Complex physical rehabilitation effect on postural control in patients with osteoporotic vertebral fractures

Makarova Ekaterina , Marchenkova Larisa , Eryomushkin Mikhail

Aim: To evaluate effect of complex physical rehabilitation on postural function in patients with osteoporotic vertebral fractures (VFs).Materials and methods: Study comprised of 90 osteoporotic patients aged 50–80 (65.4 ± 9.1 years) with VFs who were randomized as 2:1 into intervention group (group 1, n = 60) and control group (group2, n = 30). Patients in group1 received an intensive rehabilitation course including b...

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ea0070aep233 | Bone and Calcium | ECE2020

Abstract unavailable...

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ea0070aep234 | Bone and Calcium | ECE2020

Brown tumor with multiple localizations in primary hyperparathyroidism: About a case

Rihab Ajili , Sondos Arfa , Fedia Boubaker , Olfa Berrich , Alaya Wafa , Baha Zantour , Mohamed H Sfar

Introduction: A brown tumor is a rare osteolytic non-neoplastic lesion, due to an anomaly of bone metabolism, occuring in primary, secondary or tertiary hyperparathyroidism.This is a case about a brown tumor with multiple localizations seen in primary hyperparathyroidism.Observation: A 42 year old patient,with a history of Behçet disease diagnosed at the age of 38, is hospitalized in our department for the management of a fort...

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ea0070aep235 | Bone and Calcium | ECE2020

The transition range and acceleration from normocalcemia to hypercalcemia in patients with primary hyperparathyroidism: Does it provide a new perspective?

Akdoğan Leyla , Aydin Cevdet , Bașer Hüsniye , Çuhacı Seyrek Neslihan , Ersoy Reyhan , Cakir Bekir

Objective: Primary hyperparathyroidism (PHPT) is a clinical condition characterized by hypercalcemia-specific symptoms and signs caused by excessive secretion of parathormone. After the evaluation of blood calcium measurements within routine tests, the frequency of hyperparathyroidism increased and there is a marked decrease in the frequency of classical symptoms and signs. Recently, most PHPT cases are detected in the asymptomatic period, and which of these asymptomatic patie...

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ea0070aep236 | Bone and Calcium | ECE2020

Role of preoperative calcium and vitamin d therapy to prevent postsurgical hypoparathyroidism

SUH Sunghwan , Kyoung Park Mi , Kyu Kim Duk , Pak Kyoungjune

Background: Postsurgical hypocalcemia is the most common and most troubling long-term consequence of thyroidectomy. In this study, we investigated the potential role of routine calcium or vitamin D supplementation in preventing postsurgical hypoparathyroidism.Methods: We carried out a systematic search of MEDLINE and EMBASE for English-language publications using the keywords “calcium”, “vitamin D”, and “thyroid cancer&#8221...

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ea0070aep237 | Bone and Calcium | ECE2020

Is BMD still useful when we have FRAX?

Oprea Theodor-Eugen , Nistor Irina , Ioana Arhire Amalia , Alexandru Elena , Alice Albu , Sorina Martin Carmen , Sirbu Anca , Gabriela Barbu Carmen , Simona Fica

Introduction: The FRAX fracture risk assessment algorithm is able to integrate clinical risk factors independent of bone mineral density (BMD), evaluating the 10-years probability of fracture, therefore identifying patients in need for antiosteoporotic treatment, in which case bypassing the WHO (World Health Organization) criteria for densitometric diagnosis of osteoporosis.Material and Methods: We retrospectively analysed a total of 91 scans of women ag...

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ea0070aep238 | Bone and Calcium | ECE2020

Osteoporotic bone fracture hiding a rare sex chromosome disorder: Case report

Indira Fortes Delfina , Rui Mascarenhas Mario , Barbosa Ana Paula

Introduction: The XXYY Syndromeis an extremely rare sex chromosomal disorder characterized by the presence of extra X and Y chromosomes, and clinically by tall stature, dysfunctional testes associated with infertility and hypogonadism, cognitive, affective and social functioning impairments, global developmental delay, and an increased risk of congenital malformations.Case report: A 46-year-old man was referred to theFracture Osteoporosis OutpatientClini...

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ea0070aep239 | Bone and Calcium | ECE2020

The assessment of risk factors for osteoporosis and probability of osteoporotic fractures in patients undergoing medical rehabilitation

Marchenkova Laris , Makarova Ekaterina

The aim of the study was to evaluate the risk of osteoporosis and related fractures in the patients treating in in-patient rehabilitation department.Methods: The survey was conducted by means of questionnaire of 600 patients aged >50 y.o. ordinary treated in in-patient department of rehabilitation center. Risk factors for osteoporosis were assessed using IOF “One-minute osteoporosis risk test”. 10-year probability of major osteoporotic fr...

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ea0070aep240 | Bone and Calcium | ECE2020

Hypothyroidism effect on bone tissue

Krytskyy Taras

Background: The issue of hypothyroidism effect on bone tissue is underinvestigated, due to the small number of studies. In addition, it’s not easy to determine the effect of reduced thyroid function on bone strength due to the fact that these patients are usually elderly and have many additional factors for the development of osteoporosis. The purpose of the study is to assess the status of bone mineral density (BMD) in men with hypothyroidism.Mate...

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ea0070aep241 | Bone and Calcium | ECE2020

Bone turnover markers and bone quality between patients with hyperthyroidism and primary hyperparathyroidism

Sorohan Madalina , Dusceac Roxana , Niculescu Dan , Baciu Ionela , Galoiu Simona , Dobre Ramona , Sorohan Bogdan , Poiana Catalina

Background: Hyperthyroidism is widely known to be an important cause of secondary osteoporosis through the accelerated rate of bone turnover, while primary hyperparathyroidism is typically associated with loss of cortical bone and less so of trabecular bone, as seen on dual-energy x-ray absorptiometry (DXA). The evaluation of bone quality in these categories is not fully understood and needs further research. The aim of this study was to compare the bone quantity and quality, ...

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ea0070aep242 | Bone and Calcium | ECE2020

Severe hypocalcemia and psuedotumor cerebri: Old, still not so well known relationship!

Patil Madhuri , Butler Valerie , Jamil Nadia , Cameron Benjamin , Egbe Tiffany

Introduction: Clinical features of severe headache, vision loss, and papilledema; normal neuroimaging and elevated opening pressure on lumbar puncture are diagnostic of idiopathic intracranial hypertensions (IIH) or pseudotumor cerebri. Etiology is often attributed to obesity in young female patients. We present a rare case of Pseudotumor cerebri in a non-obese female patient with severe hypocalcemia.Case: A 26 year old Hispanic female patient with past ...

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22nd European Congress of Endocrinology

BiosciAbstracts