ECE2020 Audio ePoster Presentations Bone and Calcium (121 abstracts)
Fracture risk in patients with acute poliomyelitis going through late adulthood
Rutie Mamlok Sherf 1 , Dror Cantrell 2 , Keren Or 3 , Efrat Marcus 3 , Carlos Benbassat 3 , Sofia Ish Shalom 4 , Alex Shapira 5 & Ronit Koren 6
1Shamir medical center, Internal medicine A, Tzrifin, Israel; 2Shamir medical center, Internal Medicine C, Endocrine institute, Tzrifin, Israel; 3Shamir medical center, Endocrine Institute, Tzrifin, Israel; 4Lin Endocrine Research Center, Haifa, Israel; 5Shamir medical center, Polio Clinic Department of Orthopedics, Tzrifin, Israel; 6Shamir medical center, Internal Medicine A, Endocrine institue, Tzrifin, Israel
Objective: While osteoporotic fractures are reported in up to 40% of post-poliomyelitis adults, clinical guidelines regarding bone mineral density (BMD) testing and best timing for initiating treatment in this population are scarce. We assessed the characteristics of post-poliomyelitis patients, focusing on fracture and osteoporosis as the primary outcomes.
Methods: We conducted a cross-sectional retrospective data analysis from medical records of 204 post-poliomyelitis patients regarding their clinical characteristics, acute poliomyelitis disease and bone metabolism status.
Results: Our cohort included 53% females, mean age was 65 years (yrs.) at study entry and 1.7 yrs. at diagnosis of acute poliomyelitis. The lower limb was involved in 97.5% of patients, and the BMD in the affected limb was lower than the unaffected one (T score (Tsc) −1.64 vs −1.19, respectively; P = 0.06). This difference was more evident in males than females (Tsc-1.85 vs −1.02, respectively; P = 0.07), and in the fracture vs the non-fracture group (T-1.9 vs −1.25, respectively; P = 0.09). Recurrent falls were documented in 39.2% of patients. Osteoporosis was diagnosed in 20.6% of patients and was more frequent in females (P = 0.003) and patients with fractures (P = 0.002). At least one fracture occurred in 52.2% of patients, and more than one in 40.3%, with a mean age of 57 yrs. at the first fracture. Most patients fractured their affected limb (73.1%).
Conclusion: Despite the high fracture risk, osteoporosis in late-adulthood post-poliomyelitis patients appears to be underdiagnosed and undertreated. A comprehensive bone health assessment and early initiation of treatment, including anabolic agents, should be considered in this population.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more