Endocrine Abstracts

Background: Papillary thyroid microcarcinoma (PTMC) is a papillary thyroid cancer (PTC) type with a maximum diameter of ≤ 10 mm. Generally, PTMCs have good prognosis and low mortality risk. However, there are cases of PTMCs showing more biologically aggressive characteristics, such as lymph node (LN) involvement and distant metastasis.Objectives: Reveal the factors affecting the prognosis and aggressiveness of PTMCs.Methods: ...

Introduction: Papillary thyroid microcarcinomas (PTMC) are usually detected incidentally. They occur as a result of histological/microscopic examination of a thyroid removed especially for nodular goiter. Generally, the prognosis is good. However, it has been reported that lymph node (LN) metastasis is more common especially in PTMCs with tumor size > 5mm. In this study, it was aimed to show the effect of tumor size on prognosis by comparing clinicopathological data in pat...

A 87 year old woman admitted with complaints of hoarseness and a palpable mass which she noticed 1 week ago. She had hypothyroidism for 25 years. On examination, there was a hard and fixed palpable 4x4 cm mass on the right side of the neck. In laboratory evaluation, thyroid function tests were normal, thyroid auto-antibodies were positive, calcitonin was normal, C-reactive protein was 224 mg/l and liver and kidney function tests were normal. Thyroid ultrasonography revealed a ...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare, heritable syndrome characterized by a hyperparathyroidism, pituitary adenoma and pancreatic islet cells.Case: A 56-year-old male patient had a single parathyroid excised for primary hyperparathyroidism 10 years ago. He was further investigated due to hypoglycemia and a mass was found in the head of the pancreas on MRI. It was reported as neuroendocrine tumor and no recurrence was found i...

Patient is a 43 years old female without any known additional disease. A pituitary mass was seen in the cranial MRI taken due to the complaint of forgetfulness. Pituitary MRI of the patient revealed a ’large intrasellar mass of 3.2x3x2.3 cm, which expanded the sella and pressed the optic chiasm’. The patient didn’t describe any symptoms other than forgetfulness. She didn’t have galactorrhea, cushingoid or acromegaloid appearance. Patients laboratuary evalua...

Introduction: Langerhans cell histiocytosis (LCH) is a neoplastic histiocytic disorder that characterized by proliferation of abnormal Langerhans cells. The most typical organs affected by LCH are the skin and bones, though it can also affect the pituitary gland, central nervous system, liver, spleen, lungs, and other organs.Case 1: 36 year old man presented with polyuria, polydipsia and right hip pain lasting about 4 months. The pain increased in the la...

Cushing’s syndrome as a result of ectopic adrenocorticotropic hormone (ACTH) secretion, is associated with various tumors. Lung squamous cell carcinoma (LUSC) causing ectopic ACTH syndrome is a very rare condition. A 70-year-old male patient with a history of LUSC was admitted to our clinic for evaluation of worsening delirium and hypokalemia. Two courses of pembrolizumab were administered to our patient who was diagnosed with LUSC a month ago. At presentation, neurologic...

Tuberculosis (TB) is a disease that affects all organs and progresses with a wide variety of clinical manifestations. Cases of extrapulmonary tuberculosis (EPTB) are particularly difficult to diagnose because of its atypical course.Case: A 32-year-old female patient was evaluated in our clinic with the complaint of localized swelling in both supraclavicular regions (ScR) for one and a half months. There were no fevers, cough, or weight loss symptoms pres...

Neuroendocrine tumours (NETs) occur in multiple tissues and vary widely in clinical behaviour. Up to 70% of diagnosed patients have elevated circulating levels of chromogranin A, the only serum marker commonly used in clinical practice. However, its low sensitivity and the identification of confounding factors that compromise specificity have raised the need for additional or alternative markers for disease detection and management. Here we aimed to discover candidate NET mark...

Objective: The aim of our study was to determine whether there is a relationship between oxidative stress parameters and subacute thyroiditis.Material and methods: The study included 55 subacute thyroiditis patients and 30 healthy volunteers. Total antioxidant status (TAS), total oxidant status (TOS), paraoxonase (PON) and thiol/disulfide homeostasis parameters were measured by a novel and automated assay in the patient and control groups.<p class="a...