Objective: The aim of our study was to determine whether there is a relationship between oxidative stress parameters and subacute thyroiditis.
Material and methods: The study included 55 subacute thyroiditis patients and 30 healthy volunteers. Total antioxidant status (TAS), total oxidant status (TOS), paraoxonase (PON) and thiol/disulfide homeostasis parameters were measured by a novel and automated assay in the patient and control groups.
Results: TAS, TOS, oxidative stress index (OSI: TOS/TAS) and PON values were similar in both groups (P>0.05). Native thiol (NT) and total thiol (TT) values were significantly higher in the control group (P<0.001). Disulfide/native thiol (DS/NT) and disulfide/total thiol (DS/TT) levels were higher in the subacute thyroiditis group. Native thiol/total thiol (NT/TT) levels were significantly higher in the control group (P=0.02). When the all participants were evaluated, there was a negative correlation between white blood cell (WBC), neutrophil counts and sedimentation levels and only NT and TT (P <0.05). CRP levels were negative with NT, TT and NT/TT levels; there was a positive correlation with DS/NT and DS/TT levels (P <0.05). In the subacute thyroiditis group, only CRP levels were correlated with TAS (r=−0.55, P=0.004) and OSI (r=0.451, P=0.24) levels.
Conclusion: It was first shown that there may be a relationship between subacute thyroiditis and oxidative stress. Oxidative stress may also be the cause of pathophysiology in subacute thyroiditis.
18 - 21 May 2019
European Society of Endocrinology