ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P773 | DOI: 10.1530/endoabs.63.P773

Evaluation of oxidative stress parameters in subacute thyroiditis patients

Murat Dağdeviren1, Arzu Or Koca1, Tolga Akkan1, İhsan Ateş2, Salim Neşelioğlu3, Özcan Erel3 & Mustafa Altay1

1University of Health Science, Keçiören Health Administration and Research Center, Department of Endocrinology and Metabolism, Ankara, Turkey; 2University of Health Science, Numune Health Administration and Research Center, Department of Internal Medicine, Ankara, Turkey; 3University of Yıldırım Beyazıt, Department of Medical Biochemistry, Ankara, Turkey.

Objective: The aim of our study was to determine whether there is a relationship between oxidative stress parameters and subacute thyroiditis.

Material and methods: The study included 55 subacute thyroiditis patients and 30 healthy volunteers. Total antioxidant status (TAS), total oxidant status (TOS), paraoxonase (PON) and thiol/disulfide homeostasis parameters were measured by a novel and automated assay in the patient and control groups.

Results: TAS, TOS, oxidative stress index (OSI: TOS/TAS) and PON values were similar in both groups (P>0.05). Native thiol (NT) and total thiol (TT) values were significantly higher in the control group (P<0.001). Disulfide/native thiol (DS/NT) and disulfide/total thiol (DS/TT) levels were higher in the subacute thyroiditis group. Native thiol/total thiol (NT/TT) levels were significantly higher in the control group (P=0.02). When the all participants were evaluated, there was a negative correlation between white blood cell (WBC), neutrophil counts and sedimentation levels and only NT and TT (P <0.05). CRP levels were negative with NT, TT and NT/TT levels; there was a positive correlation with DS/NT and DS/TT levels (P <0.05). In the subacute thyroiditis group, only CRP levels were correlated with TAS (r=−0.55, P=0.004) and OSI (r=0.451, P=0.24) levels.

Conclusion: It was first shown that there may be a relationship between subacute thyroiditis and oxidative stress. Oxidative stress may also be the cause of pathophysiology in subacute thyroiditis.

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