Endocrine Abstracts

Introduction: Thyroid autoimmunity (TAI) commonly defined as the presence of thyroperoxidase antibodies (TPOAbs) and/or thyroglobulin antibodies (TgAbs) affects up to 15 percent of women of reproductive age and is a well-known risk factor of pregnancy loss. One of the possible explanations of obstetrical complications might be the disturbed process of placentation caused by thyroid antibodies. To test this hypothesis, we evaluated placental hormonal function and placental angi...

Background: Primary aldosteronism (PA) is mainly caused by unilateral (unilateral PA) or bilateral aldosterone-producing lesions of adrenals (bilateral PA). Accumulating findings suggest distinct metabolic profiles between patients with unilateral and bilateral PA. However, the link between the metabolic features and histopathologic findings of adrenals from patients with PA remains largely unknown.Objective: To characterize metabolic profiles with a foc...

Introduction: Gain of function mutations of RET protooncogene are associated with hereditary medullary thyrpoid cancer. There are mainly specific hot-spot RET gene mutations however they may differ between population.Aim of the study: In this study we report the prevalence of RET mutations in Polish population based on 20 years of experience of referral polish centers.Material and methods: RET ge...

Endocrine-Related Cancer, 2019, 27(2): 81–95 (DOI: https://doi.org/10.1530/ERC-19-0095)...

The reference ranges of thyroid function tests during pregnancy are still being debated, even in ethnically homogenous populations. The defining of the normal range is of importance, as it influences therapeutic decisions, particularly the use (or over-use) of levothyroxine in this vulnerable population. The study was aimed at the longitudinal assessment of thyroid function tests results in marginally iodine sufficient Polish population of pregnant women. The study was perform...

Introduction: Medullary thyroid carcinoma (MTC) accounts for 3.5-5% of thyroid cancers. The biochemical diagnosis of MTC is based on the determination of concentration of a sensitive and specific biomarker - calcitonin (CT) as well as CEA and procalcitonin (PCT). Neuroendocrine cells have the ability to produce various proteins and neuropeptides (e.g. granin proteins and INSM-1), which are secreted into the circulation with calcitonin and can be measured in the blood as so-cal...

Introduction: Polycystic ovary syndrome (PCOS) patients present with or without biochemical hyperandrogenism (HAPCOS or non-HAPCOS, respectively). Although cardiometabolic and hormonal abnormalities have been reported in women with PCOS, particularly those with hypertension, direct comparisons between normotensive (blood pressure (BP) <140/90 mmHg) patients with HAPCOS and non-HAPCOS are scarce. Data on N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) in PCO...

Background: The gradual increase in the detection rate of adrenal incidentalomas makes them a common clinical problem. The vast majority of them are benign adrenocortical adenomas. Nevertheless every patient with adrenal incidentaloma requires performing number of tests to exclude pheochromocytoma, autonomous cortisol secretion, adrenal carcinoma and primary hyperaldosteronism. Evaluation of whether adrenal incidentalomas are malignant or functional and continuing patient foll...

Background: Cardiovascular (CVS) risk factors could be present in patients with mild adrenal autonomous cortisol secretion (MACS), which could account for up to 50% of patients with adrenal adenomas. However, the most frequent CVS risk factors in MACS have not been established.Objective: The aim of the present study was to analyse the difference in CVS risk factors in patients with MACS in comparison to those with non-functioning adrenal tumour (NFAT).</...

Background : Omentin, also known as intelectin-1, is a member of the family of adipose tissue-related hormones known as adipokines, that exert anti-inflammatory, anti-atherosclerotic, and cardiovascular protective effects. Omentin expression has been detected in adipocytes as well as in a variety of extra-adipose tissues, including the ovary. Interestingly, omentin expression in the pituitary has been shown to be regulated by pituitary hormones. These observations led us to in...