Searchable abstracts of presentations at key conferences in endocrinology
Volume 2 | SFE2001 | Next issue

192nd Meeting of the Society for Endocrinology

ea0002p98 | Thyroid | SFE2001

THYROID HORMONES CONCENTRATIONS UNDER PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL STATES IN JAPANESE QUAILS

Rahman Z , Ahmad N , Akram M

Much less information is available on the thyroid hormones at different age groups, laying, non-laying and methimazole (MMI) treated japanese quails. All birds were kept under 14:10 hour light schedule and were provided feed and water adlibitum. Fifteen japanese quailsin each age groups, laying, non-laying and MMI treated were decapitated for collection of plasma. Thyroid hormones (T3 and T4) were estimated using ELISA commercial kits. The results showed that plasma thyroid ho...

ea0002p99 | Thyroid | SFE2001

HORMONAL PROFILES OF BARBRI GOAT DURING PREGNANCY, AT PARTURITION AND POSTPARTUM PERIOD

Rahman Z , Haq I , Ahmad N

Eight healthy pregnant goats, aged 2-4 years, were selected for this study. Blood samples were obtained in tubes containing EDTA at different stages of pregnancy, at parturition and on days 1, 7 and 14 postpartum. Blood from foeti was also collected on days 1 and 7 after their birth. Plasma was separated, frozen at -20 celsius till analysed for thyroid hormones (T3 and T4) using ELISA comercial kits. Thyroxine (T4) concentration was higher during prepartum, decreased significa...

ea0002p100 | Thyroid | SFE2001

Low as opposed to fully suppressed serum TSH levels in ambulant subjects; frequently a pointer to thyroid autonomy

Chatterjee S , O'Malley B , Price D , Fielding A , Aitken R

In laboratories employing 'front-line' sensitive TSH measurement, it is generally accepted that fully suppressed TSH levels (3rd generation assays) alongside normal free thyroid hormone levels indicate subclinical hyperthyroidism. However, low but not suppressed levels are often labelled as non-thyroidal illness.We investigated 25 successive ambulant individuals, identified over an 18 month period as having low but not fully suppressed TSH levels (3rd ge...

ea0002p101 | Thyroid | SFE2001

Regulation of the Liver Fatty Acid-Binding Protein Gene by Thyroid Hormone and Clofibric Acid

Iwen A , Weitzel J , Seitz H

Liver fatty acid-binding protein (LFABP) is a 14 kDa cytoplasmatic protein found in hepatocytes and enterocytes of the small intestine. It binds long chain fatty acids (LCFA) and other hydrophobic ligands and is thought to play an important role in intracellular LCFA transport.We investigated the regulation of LFABP gene expression by thyroid hormone (T3) and peroxisome proliferator-activated receptor alpha (PPARalpha) ligand clofibric acid.<p class=...

ea0002p102 | Thyroid | SFE2001

THYROID FUNCTION IN PREGNANCY: AN AUDIT

Vaidya B , Bilous M , Hutchinson R , Bilous R

Background and Aims: Recent studies have suggested that maternal thyroid dysfunction, particularly in early pregnancy, may have a detrimental effect on the neuropsychological development of offspring. In the light of these studies a local guideline was drawn which recommended screening thyroid function at booking in all pregnant women with a personal or family history of thyroid disease. The aims of this study were to assess adherence to this guideline, and to test its efficac...

ea0002p103 | Thyroid | SFE2001

Maternal hyperthyroidism disrupts neuronal development in late fetal brain

Evans I , Pickard M , Sinha A , Sampson D , Leonard A , Ekins R

Maternal hypothyroidism disrupts fetal brain development in the rat; affected parameters include several neuron-specific cytoskeletal proteins and neurotransmitter metabolic enzymes. The aim of this study was to determine whether maternal hyperthyroidism also impacts upon fetal neuronal development.Partially thyroidectomised rat dams were subcutaneously implanted with osmotic pumps to infuse either 1.5 micrograms thyroxine/100 g body weight/day (HYPER) o...