Endocrine Abstracts

Contents

• Plenary Lectures
• • European Medal Lecture
  • • Phenotype of mice harboring a thyroid hormone receptor alpha 1 gene with transdominant negative properties

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    • Society for Endocrinology Medal Lecturer

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  • Society for Endocrinology Medal Lecture
  • • A Tale of two enzymes

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    • Society for Endocrinology Medal Lecturer

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  • Asia and Oceania Medal Lecture
  • • FAT REGULATES THE NEUROENDOCRINE SYSTEM; STUDIES WITH LEPTIN

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    • Society for Endocrinology Medal Lecturer

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  • Society for Endocrinology Jubilee Medal Lecture
  • • Recent studies in normal and abnormal growth hormone secretion

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    • Society for Endocrinology Medal Lecturer

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• Young Endocrinologists Basic Science Review Lecture
• • (1)
  • • The endocrinology of renal vitamin D metabolism

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• Symposia
• • The Endocrinology of Syndrome X
  • • PPAR gamma and human insulin resistance

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    • Sex Steroid Production in Human Adipose Tissue

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    • ROLE OF INSULIN IN REGULATION OF VASCULAR ENDOTHELIAL FUNCTION

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    • WE CAN CURE CUSHING'S SYNDROME, SO CAN WE CURE THE METABOLIC SYNDROME?

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  • Molecular Evolutionary Endocrinology
  • • MOLECULAR EVOLUTION OF GHRH AND PACAP: FUNCTIONAL IMPLICATION FOR THE CONTROL OF GH SECRETION

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    • Molecular evolution of regulatory peptides - an attempt at an overview

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    • MOLECULAR EVOLUTION OF GROWTH HORMONE

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    • The evolution of the vertebrate genome: insights from gene families

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  • Maternal and Fetal Responses to Environmental Challenges of Feto-Placental Function
  • • Placental restriction and fetal endocrinology during growth retardation

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    • NUTRITIONAL AND ENDOCRINE IMBALANCES DURING ADOLESCENT PREGNANCY

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    • Nutritional Programming of Fetal Endocrinology amp Blood Pressure Control

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    • ENVIRONMENTAL MANIPULATION OF FETO-PLACENTAL GROWTH AND ENDOCRINE FUNCTION

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  • Journal of Molecular Endocrinology Symposium: Receptor Antagonists
  • • Vasopressin Receptor Antagonists

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    • Growth Hormone Antagonists

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    • Calcium Receptor Antagonists

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    • Structural Basis of Agonism and Antagonism in the Oestrogen Receptor

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• Nurses Session
• • A Legacy from Birth: a Focus on Turner's and Kallmanns
  • • Crossing the paediatric-adult divide

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    • PARENTING OPTIONS FOR ADULTS WITH TURNER'S AND KALLMANN'S SYNDROMES

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    • Being Different - The Challenges for Turner Girls

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    • Catching up with the crowd; boys don't like to stand out from the crowd

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• Oral Communications
• • Signalling from Cell Surface to Nucleus
  • • Identification of a putative receptor for N-POMC peptides

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    • LPS ACTS VIA IL-6 TO MODULATE THE EXPRESSION AND PHOSPHORYLATION OF ANNEXIN 1 IN CELL LINES DERIVED FROM THE MICROGLIA OF THE NEUROENDOCRINE SYSTEM

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    • Hesx1 represses alpha and LH beta subunit gene expression in vitro and antagonises Pitx1 transactivation, but not synergy between Pitx1 and SF-1 on LH beta subunit

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  • Vascular and Metabolic
  • • The SF1 site polymorphism of the aldosterone synthase gene (CYP11B2) influences urinary steroid production and pressor dose response to angiotensin II during dietary manipulation of the renin-angiotensin system

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    • Insulin receptor activation inhibits insulin secretion from human islets of Langerhans

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    • Regulation and impact of changes in PPARalpha expression on glucose-stimulated insulin secretion by pancreatic islets

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    • Arachidonic acid and insulin release from human islets of Langerhans

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    • Vascular reactivity and response to testosterone is unaltered in testicular feminised mice

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  • Neuroendocrinology
  • • PACE4 AS A CANDIDATE ENZYME FOR THE ENDOGENOUS CLEAVAGE OF AGOUTI-RELATED PROTEIN

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    • Hypothalamo-Pituitary-Adrenal (HPA) Responses to Centrally Administered Orexin-A Are Attenuated in Pregnant Rats

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    • Systemic and Hypothalamic Actions of Ghrelin in Regulation of Food Intake, Body Weight and Pituitary Function

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    • Tissue distribution of the mRNA of the novel endocrine regulator ghrelin and its receptor, GHS-R

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    • Transcription of corticosteroidogenic genes in human cerebellum and hippocampus

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    • Characterisation of two splice variants of a novel serine protease expressed in steroidogenic tissues

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    • PRE- AND POST-NATAL DEXAMETHASONE TREAMENT DIFFERENTIALLY ALTER ANNEXIN 1 EXPRESSION AND FUNCTION IN THE RAT NEUROENDOCRINE SYSTEM

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    • Efficacy of the new Long-Acting Lanreotide Formulation (Lanreotide Autogel) in Patients with Acromegaly

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    • The novel hypothalamic peptide Galanin-Like Peptide (GALP) stimulates food intake in male wistar rats

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  • Growth Regulation
  • • Pars intermedia pro-gamma-melanotropin and a cleft protease, a mitotic conspiracy in the pituitary?

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    • Up-regulation of Expression of Cyclooxygenase (COX)-2 and Prostaglandin E Receptors (EP2 and EP4) in HeLa cells by Seminal plasma

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    • A physiological role for pregnancy associated plasma protein E

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    • Periconceptual undernutrition in the sheep causes premature activation of the hypothalamic-pituitary-adrenal (HPA) axis resulting in preterm birth

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    • INVESTIGATION OF THE MECHANISM OF IGF-INDEPENDENT ACTIONS OF IGFBP-4

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    • Pituitary Tumour Shrinkage During Treatment of Acromegaly with Sandostatin LAR

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  • Reproduction
  • • THE ACTIVATION OF PERIPHERAL NEUROKININ RECEPTORS IN THE PATHOLOGY OF PRE-ECLAMPSIA

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    • Imprinting of the bovine Insulin-like growth factor 2 (IGF2)-gene

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    • PROLACTIN PROTECTS AGAINST CERAMIDE (C2)-INDUCED APOPTOSIS IN HUMAN OVARIAN GRANULOSA CELLS (GC)

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    • Ligand Binding to Mammalian and Non-Mammalian GnRH Receptors Apparently Involves Similar Receptor Contact Sites in Different Spatial Arrangements

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    • EFFECT OF N-6 POLYUNSATURATED FATTY ACIDS ON PROSTAGLANDIN PRODUCTION BY OVINE UTERINE EPITHELIAL CELLS IN VITRO

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    • Evidence for FSH induction of 17beta-hydroxysteroid dehydrogenase type 1 in luteinized human granulosa cells

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    • ROLE OF EP1 AND EP2 RECEPTOR SIGNALLING PATHWAYS IN THE STEROIDOGENIC RESPONSE OF HUMAN GRANULOSA-LUTEIN (GL) CELLS TO PROSTAGLANDIN (PG) E2

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    • Pregnancy outcomes in polycystic ovary syndrome

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• Poster Presentations
• • Bone
  • • Routine biochemistry in patients at risk of osteomalacia in Bradford

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    • ATORVASTATIN INCREASES FEMORAL AND VERTEBRAL BONE STRENGTH IN OSTEOPOROTIC RATS

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    • GROWTH HORMONE INCREASES FEMORAL AND VERTEBRAL BONE STRENGTH IN OSTEOPOROTIC RATS

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    • Acute regulation of bone collagen turnover and PTH by insulin and glucose: Hyperinsulinemic euglycaemic and hypoglycaemic clamp studies

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    • The effect of Glucocorticoids on growth plate chondrocyte proliferation and differentiation

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  • Clinical case reports
  • • KLINEFELTER'S SYNDROME PRESENTING WITH NON-HEALING LEG ULCERS

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    • YOUNG MALE WITH ALOPECIA, SHORT STATURE, AND RECURRENT FRACTURES

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    • THE IMPORTANCE OF THE MOTHER AS A BIOASSAY FOR DIAGNOSING AND TREATING FOETAL THYROTOXICOSIS

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    • BENIGN INTRACRANIAL HYPERTENSION - RARE CAUSE OF EMPTY SELLA SYNDROME

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    • GRAVES THYROTOXICOSIS FOLLOWING HIGHLY ACTIVE ANTI-RETROVIRAL THERAPY INDUCED IMMUNE RECONSTITUTION

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    • Myxedematous Ascites mimicking intra-abdominal malignancy with extreme elevation of CA 125

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    • Severe hyperandrogenism with polycythaemia: use of metformin as a therapeutic and diagnostic tool

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    • TUBERCULOUS HYPOPHISITIS-AN UNUSUAL CAUSE OF HYPOPITUITARISM

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    • Case report: Ganglioneuroblastoma exclusively secreting dopamine

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    • An unusual case of primary hyperparathyroidism due to four individual ectopic adenomata: a case report and review of management options

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    • MASSIVE CHILDHOOD OBESITY IN A PATIENT WITH KLYNEFELTER KARYOTYPE AND PRADDER-WILLY PHENOTYPE

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    • High uptake of I123-Tyr3 Octreotide in the thyroid gland- the significance of hot thyroid nodules in screening for carcinoid metastases

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    • Panhypopituitarism secondary to sphenoid sinus aspergilloma

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    • Crainiopharyngioma: Is It Under-Diagnosed In Patients With Klinefilter`s Syndrome?

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  • Cytokines and growth factors
  • • Effect of long-term untreated GH deficiency (GHD) and nine years of GH replacement on the quality of life (QoL) of GHD adults

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    • CIRCULATING CONCENTRATIONS OF TOTAL AND FREE LEPTIN IN GASTROINTESTINAL CANCER PATIENTS AND THE EFFECT OF MEGESTEROL ACETATE

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    • The influence of IGFBP-3 on colonic epithelial cell proliferation and apoptosis

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    • INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN- 4 (IGFBP-4) ISOFORMS IN THE HUMAN OVARY-IDENTIFICATION OF A NEW ISOFORM?

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    • EFFECT OF INTRAVENOUS INFUSION OF RECOMBINANT OVINE LEPTIN ON UNCOUPLING PROTEIN (UCP)-1 ABUNDANCE IN PERIRENAL ADIPOSE TISSUE IN THE LATE GESTATION SHEEP FETUS

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    • PRODUCTION AND ACTIVATION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN -4 (IGFBP-4) PROTEASE IN THE HUMAN OVARY

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  • Diabetes and metabolism
  • • Differential expression of the two mouse insulin genes in MIN6 cells

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    • POSTPRANDIAL HYPOGLYCAEMIA IN GATESHEAD

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    • Glucocorticoid excess leads to redistribution of available pyruvate from oxidation to maintain a normal rate of lactate formation via up-regulation of skeletal-muscle pyruvate dehydrogenase kinase 4 expression

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    • SCREENING FOR DIABETES AND ASYMPTOMATIC HYPERGLYCAEMIA IN ACUTE MYOCARDIAL INFARCTION

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    • CUTANEOUS VASOMOTOR RESPONSE IN PATIENTS WITH MICROALBUMINURIA

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    • Use of fluoride oxalate tubes to monitor the accuracy of home blood glucose measurements during pregnancy in patients with insulin dependent and gestational diabetes

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    • Renal calcium output in the offspring of diabetic rats

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    • NORMALISATION OF 150 kDa INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 TERNARY COMPLEX FORMATION DURING PEGVISOMANT THERAPY IN ACROMEGALY

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    • Ethnic differences in the comparison of several surrogate estimates of insulin resistance and beta-cell function in healthy women

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  • Endocrine tumours and neoplasia
  • • Medical therapy of macroprolactinomas in men: (1) prevalence of hypopituitarism at diagnosis and (2) proportion of cases exhibiting recovery of pituitary function

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    • A role for ceramide during N-(4-hydroxyphenyl) retinamide-induced cytotoxicity in human breast cancer cells

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    • Minimally invasive parathyroid surgery with intra-operative PTH measurement: an economical approach to the management of primary hyperparathyroidism

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    • Effect of metallopeptidase inhibitors and growth factors on MCF-7 cell proliferation

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    • ECTOPIC ACTH SECRETION DUE TO COMBINED MALIGNANT LUNG TUMOR

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    • Possible Functional Regression of Insulinoma with Prolonged Octreotide

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    • One centres experience of using Sandostatin lAR for the treatment of Acromegaly

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    • Tumour Induced Hypoglycaemia Treated Successfully With Growth Hormone

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    • Variable expression of IGF-1 in breast cancer influences expression of c-myc and Cox-2

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    • A Role for Paracrine Expression of Ghrelin in the Colon?

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  • Genetics
  • • Exercise-induced, ACE genotype-dependent rise in serum Angiotensin I-Converting Enzyme

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    • Klinefelter-like phenotype and primary infertility in a male with an Xq inversion

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    • MITOCHONDRIAL GLYCEROL-3-PHOSPHATE-DEHYDROGENASE: ITS TESTIS EXPRESSION AND REGULATION

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    • Association analysis of the Deleted in colorectal carcinoma (DCC) gene in Graves' disease

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    • A Case of Mu1tiple Endocrine Neoplasia Type 1 (MEN1) Caused By A New Genetic Mutation

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  • Growth and development
  • • Growth hormone (GH) deficient survivors of childhood cancer: the role of GH replacement during adult life

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    • Effects of fetal adrenalectomy on the binucleate cell population in ovine placenta near term

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    • Are Hox genes responsible for the phenotypic switching and zonation of the adult adrenal cortex?

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    • Insulin-like growth factor acts as a Nitric-oxide-dependant vasodilator in normotensive but not hypertensive rat aortas

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    • THE EFFECT OF CHRONIC PROLACTIN ADMINISTRATION TO GROWING RATS ON UNCOUPLING PROTEIN (UCP)-1 ABUNDANCE IN INTRASCAPULAR BROWN ADIPOSE TISSUE (BAT)

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    • IMPACT OF MATERNAL NUTRIENT RESTRICTION IN EARLY TO MID GESTATION ON THE RELATIONSHIP BETWEEN PLASMA CORTISOL AND BLOOD PRESSURE IN LATER LIFE

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    • Does the adverse lipid profile in humans with severe GHD worsen from childhood to adult life?

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    • MOLECULAR EVOLUTION OF GROWTH HORMONE IN PRIMATES

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    • MOLECULAR EVOLUTION OF GROWTH HORMONE IN CETARTIODACTYLA

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    • Effect of birth weight on hypothalamo-pituitary adrenal (HPA) function in postnatal pigs

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  • Neuroendocrinology
  • • Elderly people with hypothalamic-pituitary disease and untreated growth hormone deficiency: Clinical outcome, body composition, lipid profiles and quality of life after 2 years compared to controls

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    • MIF (Macrophage Migration Inhibitory Factor) is over-expressed in the nucleus of pituitary adenoma cells

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    • Sex differences in the pituitary-adrenocortical response to acute hypoxia in the ovine fetus during late gestation

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    • The effect of metabolites of MDMA ('ecstasy') on the release of vasopressin in vitro

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    • PREVAILING ADVERSE INTRAUTERINE CONDITIONS ALTER THE PLASMA VASOPRESSIN RESPONSE TO ACUTE HYPOXAEMIA IN FETAL SHEEP

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    • ANNEXIN 1 EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES (PBLs) FROM PATIENTS WITH ENDOCRINE DISEASES CORRELATES WITH THE SERUM CORTISOL

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    • Calcitonin of the puffer fish (Fugu Rubripes)

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    • NELF, Leptin and NPY receptors are expressed by human olfactory neuroepithelial cells

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    • SAFETY AND MORTALITY DURING GROWTH HORMONE (GH) REPLACEMENT THERAPY IN 4457 ADULT GH-DEFICIENT PATIENTS - A KIMS DATABASE ANALYSIS

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    • Prenatal maternal nutrient restriction and regulation of the hypothalamo-pituitary-adrenal (HPA) axis in adult offspring

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    • BODY WEIGHT AND PROLACTIOMA: A RETROSPECTIVE STUDY

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    • FSH HUMORAL LEVELS IN RELATION WITH PITUITARY IMMUNOPOSITIVE GONADOTROPINOMAS

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  • Reproduction
  • • Characterisation of the adult mouse Leydig cell transcriptome using serial analysis of gene expression (SAGE)

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    • 1,25-HYDROXYVITAMIN D3 HAS A DIRECT EFFECT ON STEROID PRODUCTION BY HUMAN GRANULOSA CELLS

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    • Morphological differences in preantral follicle distribution between normal and androgenised ovine ovaries

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    • RGS proteins in the myometrium: differential expression in human pregnancy and labour

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    • Leptin and body fat: their roles in the control of reproductive activity in male Rhabdomys pumilio

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    • IMPACT OF MATERNAL NUTRIENT RESTRICTION IN EARLY TO MID GESTATION ON INSULIN-LIKE GROWTH FACTOR-I (IGF-I) RECEPTOR mRNA ABUNDANCE IN THE OVINE PLACENTA

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    • Alternative splicing of 15-hydroxyprostaglandin dehydrogenase (PGDH) in human chorio-decidua, placenta and myometrium

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    • IMPROVEMENT OF MALE HYPOGONADISM IN SEVERE OBESITY DURING WEIGHT LOSS AFTER BARIATRIC SURGERY

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    • Investigating the role of cAMP-dependent protein kinase (PKA) in progesterone secretion by luteinizing human granulosa cells

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  • Signalling
  • • Demonstration of functional vascular estrogen receptor beta

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    • A Threonine-Doublet within the Carboxyl-Terminal Tail of a Non-Mammalian Gonadotropin-Releasing Hormone Receptor is Critical for Rapid Agonist-Induced Internalization

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    • Expression of Orexin-A and and functional Orexin type-2 receptors in human fetal and adult adrenals: Implications in adrenal function and energy homeostatsis

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    • A cDNA microarray analysis of growth hormone-dependent gene expression in normal and laron fibroblasts

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  • Steroids
  • • MECHANISMS OF FALSE POSITIVE DEXAMETHASONE SUPPRESSION TESTS

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    • METABOLISM OF ANDROGEN SUBSTRATES BY GINGIVAL FIBROBLASTS IN RESPONSE TO NICOTINE AND OESTRADIOL

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    • MODULATION OF ANDROGEN METABOLISM BY OESTRADIOL AND FINASTERIDE IN RESPONSE TO PHENYTOIN IN GINGIVAL FIBROBLASTS

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    • MODULATION OF ANDROGEN METABOLISM BY ALKALINE PHOSPHATASE AND ITS INHIBITION BY LEVAMISOLE IN ORAL PERIOSTEAL FIBROBLASTS

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    • EFFECTS OF PHENYTOIN, HISTAMINE AND LEVAMISOLE ON ANDROGEN METABOLISM IN GINGIVAL FIBROBLASTS

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    • The effects of inhaled corticosteroids on cortisol production can be distorted by analytical methodology and clinical study design

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    • PARACRINE STIMULATION OF OVARIAN 11BETA-HYDROXYSTEROID DEHYDROGENASE (11BETA-HSD) ACTIVITY IN HUMAN GRANULOSA-LUTEIN (GL) CELLS BY PROSTAGLANDINS

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    • MODULATION OF CORTISOL METABOLISM DURING TREATMENT OF ACROMEGALY IS INDEPENDENT OF BODY COMPOSITION AND INSULIN SENSITIVITY

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    • AMBULANT ALDOSTERONE/ ACTIVE RENIN RATIOS AS A SCREEN FOR CONN'S SYNDROME; INFLUENCE OF DRUG THERAPY

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    • CONVENIENT 'DELFIA' IMMUNOFLUORIMETRIC ASSAYS FOR PLASMA AND URINE 18-HYDROXYCORTISOL

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    • THE UTILITY OF BASAL ACTH MEASUREMENT DURING MORNING SYNACTHEN TESTING

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    • Assessment of the hypothalamic-pituitary-adrenal axis in patients who have been on long term oral steroids

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    • HUMAN URINARY CORTISOL METABOLITES, SALIVARY AND URINARY FREE CORTISOL AND CORTISONE: CIRCADIAN CHANGES AND EFFECT OF HYDROCORTISONE DOSING

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  • Thyroid
  • • THYROID HORMONES CONCENTRATIONS UNDER PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL STATES IN JAPANESE QUAILS

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    • HORMONAL PROFILES OF BARBRI GOAT DURING PREGNANCY, AT PARTURITION AND POSTPARTUM PERIOD

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    • Low as opposed to fully suppressed serum TSH levels in ambulant subjects; frequently a pointer to thyroid autonomy

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    • Regulation of the Liver Fatty Acid-Binding Protein Gene by Thyroid Hormone and Clofibric Acid

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    • THYROID FUNCTION IN PREGNANCY: AN AUDIT

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    • Maternal hyperthyroidism disrupts neuronal development in late fetal brain

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