Searchable abstracts of presentations at key conferences in endocrinology
Volume 2 | SFE2001 | Next issue

192nd Meeting of the Society for Endocrinology

ea0002sp5 | (1) | SFE2001

The endocrinology of renal vitamin D metabolism

Bland R

The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D3), is vital for calcium/phosphate homeostasis, bone cell differentiation and modification of immune responses. Synthesis of 1,25D3 is catalysed by the mitochondrial cytochrome P450 enzyme 25-hydroxyvitamin D3-1α-hydroxylase (1α-OHase; CYP27B1). Although 1α-OHase has been detected at several extra-renal sites, circulating levels of 1,25D3 appear...