Endocrine Abstracts

In adipose tissue, estrogens are synthesized in the mesenchymal preadipocyte cells. This arises because aromatase, the enzyme responsible for estrogen biosynthesis is located in these cells as distinct from differentiated adipocytes. Regulation of aromatase expression in these cells is primarily due to a distal promoter, promoter I.4. Differentation of preadipocytes to the lipid-laden phenotype results in loss of aromatase transcripts coincident with increased PPARgamma expres...

Evan Simpson, Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia AbstractProfessor Simpson is generally recognised as a world leader in the area of oestrogen biosynthesis. His lab was the first to clone the cDNA and subsequently the human gene encoding aromatase, the enzyme responsible for oestrogen biosynthesis. They were the first to show that tissue-specific regulation of this gene is media...