Endocrine Abstracts

The orphan nuclear receptor steroidogenic factor 1 (SF-1) initially wasisolated as a key regulator of the cytochrome P450 steroid hydroxylases.Knockout mice lacking steroidogenic factor 1 (SF-1) have a complexendocrine phenotype that encompasses adrenal and gonadal agenesis,impaired expression of gonadotropins by pituitary gonadotropes, andstructural abnormalities of the ventromedial hypothalamic nucleus (VMH).These multiple defects complicate efforts t...

Keith Parker, University of Texas Southwestern Medical Center, Dallas, TX, USA AbstractThe son of two clinician-scientists, Keith Parker attended Williams College, and then received his M.D./Ph.D. degrees from Washington University School of Medicine in 1981. His graduate work with Donald Shreffler focused on structure-function relationships of the complement component, C4....