Searchable abstracts of presentations at key conferences in endocrinology
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Volume 5
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BES2003
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22nd Joint Meeting of the British Endocrine Societies
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Summary
Abstracts
Contents
Plenary Lectures
Clinical Endocrinology Trust Visiting Professor Lecture
Neuroendocrine regulation of bone mass - GH deficiency and resistance states
ea0005s1
Clinical Endocrinology Trust Visiting Professor Lecture
ea0005s1biog
Society for Endocrinology Dale Medal Lecture
How the brain controls appetite
ea0005s2
Society for Endocrinology Medal Lecture
ea0005s2biog
Society for Endocrinology Transatlantic Medal Lecture
Steroidogenic factor 1, a key mediator of endocrine development
ea0005s3
Society for Endocrinology Transatlantic Medal Lecture
ea0005s3biog
British Thyroid Association Pitt-Rivers Lecture
The Na++/I- - symporter (NIS): Physiological and pathophysiological implications
ea0005s4
British Thyroid Association Pitt-Rivers Lecture
ea0005s4biog
Clinical Endocrinology Trust Lecture
Growth hormone outgrows growth
ea0005s5
Clinical Endocrinology Trust Lecture
ea0005s5biog
Symposia
Androgens and Prostate Cancer
Androgen action in the prostate
ea0005s6
Androgens vs estrogens in prostate cancer
ea0005s7
Survey of gene expression during prostate cancer progression using tissue microarrays
ea0005s8
Trophic Control of Size
Genes and growth and endocrine diseases
ea0005s9
Growth regulation during Drosophila development
ea0005s10
The role of the EG-VEGF family in the regulation of angiogenesis in endocrine glands
ea0005s11
Apoptosis/Survival Signalling
Building and demolishing cancers in vivo
ea0005s12
The role of mitochondria in cell death
ea0005s13
Phosphoinositide 3-kinase dependent lipid signals in cellular survival responses
ea0005s14
Cell proliferation and death in endocrine glands: The corpus luteum paradigm
ea0005s15
Dominant Endocrine Cancer Syndromes
VHL and the genetics of phaeochromocytoma
ea0005s16
VHL and HIF, a basis for VHL pathogenesis
ea0005s17
Function of menin, product of the MEN1 tumor suppressor gene
ea0005s18
Genetics and management of multiple endocrine neoplasia type 1 (MEN1)
ea0005s19
The Adipocyte as an Endocrine Organ
The role of adiponectin in carbohydrate and lipid metabolism
ea0005s20
Monogenic obesity
ea0005s21
Nuclear receptors in metabolic control
ea0005s22
Reduced intra-adipose glucocorticoid regeneration: A novel adaptive response to, and therapy for, the metabolic syndrome
ea0005s23
Prolactin: Novel Aspects
Regulation of prolactin gene expression
ea0005s24
Prolactin receptor expression and prolactin-mediated effects in adipose tissue
ea0005s25
Role and regulation of decidual PRL expression: Implications for pregnancy failure
ea0005s26
PRL and its antagonist: The yin and yang of growth versus differentiation
ea0005s27
Hot Topics
Effects of interleukin-6 (IL-6) deficiency on exercise capacity in mice
ea0005s28
Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: A cohort study
ea0005s29
A natural product that lowers cholesterol as an antagonist for the bile acid receptor FXR
ea0005s30
Radioiodine Biology in the 21st Century
Thyroid eye disease and radioiodine therapy for Graves' hyperthyroidism
ea0005s31
NIS and thyroid cancer
ea0005s32
The molecular genetics of post Chernobyl thyroid cancer
ea0005s33
Clinical Management Workshops
Fatigue. Is it Endocrinology?
Management of chronic fatigue
ea0005s34
The neuroendocrinology of chronic fatigue syndrome
ea0005s35
Psychiatry and chronic fatigue
ea0005s36
HRT - The Good, the Bad and the Ugly
HRT and the heart
ea0005s37
The effect of oestrogen on brain ageing
ea0005s38
HRT and fracture prevention
ea0005s39
HRT and fracture prevention
ea0005s40
Management of Craniopharyngioma
Hypothalamic syndromes: Their investigation and treatment in comparison with craniopharyngiomas
ea0005s41
To irradiate or not to irradiate craniopharyngiomas
ea0005s42
Quality of survival and prognosis for children with craniopharyngioma
ea0005s43
Focused Science Session
Tissue Engineering in Endocrinology
Tissue engineering
ea0005s44
Tissue engineering: The study of human embryonic stem cells
ea0005s45
Nurses Session
Ethical Dilemmas
Understanding the matter of consent
ea0005s46
Ethical implications of tissue retrieval
ea0005s47
When the results don't match the symptoms ndash the use and abuse of thyroxine medication in hypothyroidism
ea0005s48
Young Endocrinologists Workshop
Alternative Careers for Endocrine Researchers
Clinical biochemistry
ea0005s49
Research for clincial paediatric endocrinologists
ea0005s50
Sales opportunities in biotech firms
ea0005s51
A career in medical education and communication
ea0005s52
Oral Communications
Reproduction and Development
Agonists of peroxisome proliferator-activated receptor-gamma (PPARgamma) regulate steroidogenesis in a human granulosa cell line (HGC-5)
ea0005oc1
A functional polymorphism in the extrapituitary prolactin promoter has opposing effects on prolactin gene expression in T-lymphocytes and endometrial stromal cells but is not associated with unexplained recurrent miscarriages
ea0005oc2
Lipocortin-1 is modulated by glucocorticoids in the human endometrium
ea0005oc3
Early developmental indices of placental growth restriction in the overfed adolescent sheep
ea0005oc4
Angiotensinogen; the key to programming female hypertension?
ea0005oc5
Hypoxia-ischaemia and the insulin-like growth factor (IGF) family at birth
ea0005oc6
Metformin is more effective than Dianette in the treatment of hirsutism in women with PCOS
ea0005oc7
Classification of the spectrum of aortic dysmorphology by magnetic resonance imaging in adults with Turner syndrome
ea0005oc8
Cardiovascular Endocrinology
Use of glucocorticoids and risk of cardiovascular disease in a population-based cohort study of 164,133 participants
ea0005oc9
Genomic analysis of congenic rat strains identifies a new candidate gene for human hypertension
ea0005oc10
Characterisation of the metabolic syndrome in the stroke prone spontaneously hypertensive rat and the contribution of the Y chromosome
ea0005oc11
Corticosteroid effects at the trafficking level on the pathway of key importance in blood pressure control
ea0005oc12
Assessment of the vasodilatory action of testosterone in isolated human pulmonary and mesenteric arteries and veins
ea0005oc13
A single nucleotide polymorphism in the p22phox gene affects arterial compliance
ea0005oc14
A novel PPAR gamma mutation (R357X), associated with partial lipodystrophy, helps define the phenotype of the human PPAR gamma ligand resistance (PLR) syndrome
ea0005oc15
Identification of novel glucocorticoid receptor isoforms in rat and human lung
ea0005oc16
Obesity and Diabetes
Autocrine FGF-2 is essential for human preadipocyte differentiation
ea0005oc17
Expression of adiponectin protein in human fat: the effect of type 2 diabetes and obesity
ea0005oc18
Obesity reduces resistin immunoreactivity in mouse brain
ea0005oc19
PYY and decreased appetite following jejunum intestinal bypass in rats
ea0005oc20
5alpha-Reduced glucocorticoid metabolites: Novel endogenous activators of glucocorticoid receptors(GR)
ea0005oc21
Defining the molecular basis for apparent cortisone reductase deficiency reveals a novel redox potential mechanism within the endoplasmic reticulum
ea0005oc22
Expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 are increased following weight loss
ea0005oc23
Downstream consequences of increased 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1) activity and mRNA in adipose tissue in human obesity
ea0005oc24
Brain and Behaviour
Novel methods of delivery of neurotrophic growth factor genes to CNS neurons
ea0005oc25
11beta-Hydroxysteroid dehydrogenase type 2 (11beta-HSD2), a protector of the developing brain
ea0005oc26
Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to p38 MAPK
ea0005oc27
Follistatin is secreted from pituitary folliculo-stellate cell lines by an ABCA1 transporter
ea0005oc28
Decreased anxiety-related behaviour and increased spatial memory retention in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice
ea0005oc29
Elevated circulating levels of cocaine- and amphetamine regulated transcript (CART) in anorexia nervosa
ea0005oc30
A role for arcuate cocaine and amphetamine regulated transcript in hyperphagia, thermogenesis and cold adaptation
ea0005oc31
Localisation and regulation of cocaine- and amphetamine-regulated transcript (CART) in the anterior pituitary gland
ea0005oc32
Thyroid and Calcium
Contrasting skeletal phenotypes in mice with an identical mutation targeted to either the TRalpha or TRbeta gene
ea0005oc33
Abnormalities of thyroid function in the POMC-null mouse
ea0005oc34
Five human thyroid hormone receptor beta1 5'-UTR isoforms differentially regulate levels of gene expression and protein translation in individual tissues
ea0005oc35
Prophylactic steroids are unnecessary in patients with thyroid-associated ophthalmopathy receiving radioiodine therapy
ea0005oc36
Sodium-iodide (NIS) gene expression is a potential prognostic indicator for thyroid cancer and is inhibited by pituitary tumor transforming gene (PTTG)
ea0005oc37
Idiopathic (Normocalcaemic) hypercalciuric nephrolithiasis due to an activating calcium sensing receptor mutation
ea0005oc38
Parafibromin germline mutations in patients with parathyroid tumours
ea0005oc39
Matrix metalloproteinase 13 (MMP13) mutation causes spondyloepimetaphyseal dysplasia (SEMD), Missouri variant
ea0005oc40
Poster Presentations
Bone
Osteoblastic gene expression in cells of the adipocytic lineage
ea0005p1
Effect of active acromegaly on parathormone circadian rhythm and phosphocalcium metabolism
ea0005p2
Functional and association studies of calcium sensing receptor polymorphisms and mediators of calcium homeostasis
ea0005p3
Hormone replacement treatment (HRT) increases circulating insulin-like growth factor binding protein-4 concentration
ea0005p4
Determination of a correlation between release of beta c-terminal telopeptides and area of resorption by recombinant rankl-generated human osteoclasts
ea0005p5
Parathyroid responsiveness to parathyroid hormone (1-34) infusion is altered in adult growth hormone deficiency following growth hormone replacement
ea0005p6
Effects of thyroid hormone (T3) on fibroblast growth factor signalling in bone
ea0005p7
IGF-I reverses dexamethasone induced growth retardation in mouse embryonic metatarsal cultures
ea0005p8
Comparison of PTH concentration and phosphocalcium metabolism in treated adult growth hormone deficient patients with normal and reduced bone mineral density
ea0005p9
The Short Stature Homeobox containing Gene (SHOX) inhibits alkaline phosphatase (ALP) production by C3H10T1/2 cells treated with retinoic acid (RA)
ea0005p10
Effects of growth hormone replacement on parathyroid gland responsiveness to hypo- and hypercalcaemic stimuli in adult growth hormone deficiency
ea0005p11
Iranian national osteoporosis prevention plan-1 (inop-1): preliminary report: Relationship between vitamin d deficiency and markers of bone metabolism in urban 20-69 year-olds in Tehran, Iran
ea0005p12
Hypophosphatemic rickets as a consequence of pregnancy: A case report
ea0005p13
Clinical Case Reports
Combined pituitary hormone deficiency (CPHD) with adult-onset corticotropin deficiency but without evidence for PROP-1 or HESX1 mutations
ea0005p14
Rapid enlargement of thyroid neck swelling in two patients with thyroid dysfunction
ea0005p15
Recurrent ovulation from an ovo-testis in 46XX/47XXY (mosaic) hermaphroditism: Serial high-resolution ultrasound characterisation
ea0005p16
A novel DAX-1 gene mutation with adrenal hypoplasia congenita, differing degrees of hypogonadism and decreased bone mineral density
ea0005p17
Gender identity disorder in an Irish population
ea0005p18
Addisonian crisis in a patient with a progressive polyneuropathy
ea0005p19
Large parathyroid adenomas associated with vitamin D deficiency - quaternary hyperparathyroidism?
ea0005p20
The Pituitary Foundation: A national patient support group
ea0005p21
A little hard to swallow. A rare cause of dysphagia in scleroderma
ea0005p22
Cushing's disease in adolescence
ea0005p23
Vanishing bone: Stabilisation of Gorham-Stout disease during antiresorptive therapy
ea0005p24
An unusual presentation of hypopituitarism
ea0005p25
Abstract unavailable
ea0005p26
Delayed carbimazole induced agranulocytosis precipitating thyroid crisis
ea0005p27
Fatal cardiac arrest in a woman with thyrotoxic crisis and sarcoidosis
ea0005p28
Complimentary hyponatraemia
ea0005p29
Failure of metformin and pioglitazone in the treatment of congenital generalised lipodystrophy
ea0005p30
Tumour metastases following laparoscopic resection of adrenal cortical carcinoma
ea0005p31
Infantile methylmalonic aciduria caused by maternal pernicious anaemia
ea0005p32
80 years of hyperandrogenism
ea0005p33
Developing an endocrine nurse specialist post can improve service to patients with endocrine disease
ea0005p34
Steroid responsive hypervitaminosis D due to sarcoid myopathy
ea0005p35
Clear cell ovarian adenocarcinoma presenting with parathyroid hormone-related protein-dependent hypercalcaemia
ea0005p36
A case of ectopic ACTH with severe opportunistic infection
ea0005p37
Clinical features of phaeochromocytomas presenting as crises to an intensive care unit
ea0005p38
Coexisting struma ovarii and Graves' disease
ea0005p39
Testosterone implant therapy- an audit of patients' views
ea0005p40
Incidental non secretory pituitary adenoma in a case of ectopic ACTH induced Cushing's syndrome
ea0005p41
The use of intravenous etomidate infusion in the acute control of life-threatening hypercortisolaemia in a case of ACTH-dependent Cushing's syndrome
ea0005p42
Cortisol producing pheochromocytoma in pregnancy
ea0005p43
Cyclical Cushing's syndrome associated with a pituitary gonadotrophinoma
ea0005p44
Tumour induced hypoglycaemia
ea0005p45
Acromegaly with hyperprolactinaemia - marked response to cabergoline therapy in a patient with a co-secreting tumour
ea0005p46
The UK national acromegaly database
ea0005p47
An unusual case of gynaecomastia
ea0005p48
Pituitary carcinoma presenting as an aggressive non-functioning adenoma
ea0005p49
Hirsutism and subclinical Cushing syndrome
ea0005p50
Adrenal rest tissue of the testes: A case report
ea0005p51
Concurrence of primary hypothyroidism, epilepsy and benign intracranial hypertension in an adult
ea0005p52
Vanishing sellar masses: Two case reports
ea0005p53
Lymphocytic hypophysitis. A case report
ea0005p54
Growth hormone deficiency and pregnancy
ea0005p55
An occult cause of hirsutism
ea0005p56
Young woman with galactorrhoea
ea0005p57
A case of Carney complex with unusual presentation
ea0005p58
Calcitonin in nodular thyroid disease
ea0005p59
Resolving adrenal insufficiency following haemorrhage into a pituitary adenoma
ea0005p60
Androgenisation during pregnancy - A case report
ea0005p61
Unexplained profound transient hypocalcaemia in a young male
ea0005p62
An unusual case of thyroid enlargement in pregnancy
ea0005p63
Persistent hypoglycaemia associated with neoplasia: A case of Doege-Potter syndrome
ea0005p64
Empty sella presenting as a syndrome of inappropriate antidiuretic hormone secretion
ea0005p65
Comparative
Sheehan's syndrome and non-functioning pituitary adenoma - a comparison of clinical characteristics and response to growth hormone replacement
ea0005p66
Prostaglandins modulate the renal actions of antidiuretic hormone in the Pekin duck
ea0005p67
Do plasma osmolality methods meet clinical requirements?
ea0005p68
Analysis of human renal chloride channel (hCLC-5) mutations based on a three-dimensional model, suggests a structural-functional relationship
ea0005p69
Cytokines and Growth Factors
Growth hormone (GH) insensitivity due to a mutation in the cytoplasmic domain of the GH receptor distal to Box 1
ea0005p70
A growth hormone receptor (GHR)- glycophosphatidylinositol (GPI) chimera acts as a receptor antagonist
ea0005p71
Relationships between IL-6 levels and anthropometric, metabolic and hormonal parameters in women with PCOS and the effect of treatment with metformin
ea0005p72
Increased angiogenesis but not lymphangiogenesis in parathyroid proliferative lesions: A possible role for FGF-2
ea0005p73
Leptin enhances expression of CD11b by human neutrophils through TNF-alpha
ea0005p74
Overexpression of somatostatin receptors 1 and 5, and VEGF and its receptors FLK and FLT in laryngeal carcinoma: Potential targets for anti-tumoral therapy?
ea0005p75
Development of a bioassay for leptin agonists and antagonists
ea0005p76
Serum concentrations of interleukin-18 and tumour necrosis factor alpha are associated to the features of the metabolic syndrome X in adults
ea0005p77
Concentrations of serum Interleukin-18, tumour necrosis factor alpha and plasma malondialdehyde are associated with body mass index in healthy adults
ea0005p78
Diabetes, Metabolism and Cardiovascular
Identification of the gene causing familial juvenile hyperuricaemic (Gouty) nephropathy
ea0005p79
Influence of the Y chromosome on inter-individual variation in cholesterol serum levels of young men
ea0005p80
Effects of the 11beta hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in human obesity
ea0005p81
Effect of grape procyanidins on proliferation and apoptosis of pancreas beta cells
ea0005p82
Testosterone is a dilator of resistance arteries in men with congestive heart failure
ea0005p83
Orlistat use outside of clinical trials: The Irish experience
ea0005p84
Adrenomedullin and proadrenomedullin N-terminal 20 peptide have opposing effects on CRLR gene expression in human adrenal cells
ea0005p85
Autosomal dominant neurohypophyseal diabetes insipidus associated with a glutatmine47 deletion
ea0005p86
Circulating IGFBP-3 concentration is independently associated with insulin resistance and BMI
ea0005p87
Mechanisms of splicing inhibition in apolipoprotein B exon 26 (ApoB ex26)
ea0005p88
OGIS: An index of insulin sensitivity in a clinical setting
ea0005p89
Paradoxical correlation between serum zinc and neutrophil respiratory burst in the resting and stimulated states in type 2 diabetic patients with foot ulcers
ea0005p90
Baseline clinical characteristics and response to growth hormone replacement therapy in adults with isolated growth hormone deficiency in comparison with multiple pituitary hormone deficiencies
ea0005p91
Cardiovascular risk factors in obese children and their association with insulin resistance
ea0005p92
Reduced insulin sensitivity in healthy glucose tolerant first degree relatives of patients with Type 2 diabetes mellitus
ea0005p93
Glycaemic control, weight change and treatment : Examining the relationship in Type 2 diabetes
ea0005p94
Subcutaneous and visceral preadipocytes from pre-pubertal children show site-specific differences in insulin action
ea0005p95
The effect of menopausal status on the biological variation of insulin resistance
ea0005p96
Altered insulin sensitivity and secretion in sotos syndrome
ea0005p97
The predictive factors for gestational diabetes mellitus and postpartum diabetes mellitus
ea0005p98
Hypertension in diabetics and non-diabetics; degree of blood pressure control and antihypertensive agents
ea0005p99
Treatment of coronary disease and effects on endogenous testosterone levels
ea0005p100
Octreotide LAR - a patient and nurse perspective
ea0005p101
Early onset Type 2 diabetes in an Irish population
ea0005p102
A 5 year retrospective analysis of diabetes ketoacidosis
ea0005p103
Type 2 diabetes in Alstrom syndrome: Targeting insulin resistance with a thiazolidinedione
ea0005p104
Polycystic ovary syndrome (PCOS) in Sri Lankans
ea0005p105
Metformin. Its effect on weight loss in obese patients with or without polycystic ovary syndrome
ea0005p106
Mass screening for diabetes: New horizon with computer aided diagnosis system?
ea0005p107
Hypopituitarism presenting as hypoglycaemia in Type 2 diabetes
ea0005p108
Blood stream infections are common in admitted diabetics
ea0005p109
Timing of insulin administration amongst diabetic patients
ea0005p110
Abnormal immunoglobulin A and D levels in children with type 1 diabetes
ea0005p111
The effect of blood glucose in non-diabetic pregnant women on their infants' weight
ea0005p112
Unusual causes for hypokalaemia in diabetics
ea0005p113
Endocrine Tumours and Neoplasia
Familial isolated primary hyperparathyroidism due to germline multiple endocrine neoplasia Type 1 (MEN1) mutations
ea0005p114
Prostate and ovarian cancer cell responses to treatment with 2-substituted oestrogen sulphamates in vitro
ea0005p115
Dysregulated extra-renal synthesis of 1,25-dihydroxyvitamin D3: A novel cause of hypercalcemia associated with ovarian dysgerminomas
ea0005p116
Parathyroid tumours harbour parafibromin somatic mutations, consistent with the Knudson 'two-hit' hypothesis
ea0005p117
Genetic abnormalities in carcinoid tumours
ea0005p118
Hyperparathyroidism-jaw tumour syndrome (HPT-JT) in Romany families from Portugal is due to a founder mutation of parafibromin
ea0005p119
Clinical and biochemical prognostic indicators at diagnosis in 117 midgut carcinoid tumours
ea0005p120
Differential modulation of key steroidogenic enzymes through orphan nuclear transcriptional regulation may control the diverse production of cortisol and adrenal androgens
ea0005p121
IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75
ea0005p122
Preoperative determination of serum thyroglobulin may identify patients with differentiated thyroid cancer who might recur without increased thyroglobulin
ea0005p123
Acromegaly: A study of epidemiological characteristics and treatment outcomes
ea0005p124
Dysregulation of the Vitamin D axis in colorectal cancer
ea0005p125
Outcomes in acromegaly: A retrospective study of 419 patients from the West Midlands region of the United Kingdom
ea0005p126
Proliferative regulation of human breast cancer cells by dietary phytoestrogens: Mechanisms of estrogen receptor-mediated signalling
ea0005p127
CYP27b and CYP24 expression combine to determine 1,25 Dihydroxyvitamin D3 insensitivity in breast cancer cells
ea0005p128
Stable iodide and radioiodide transport in extrathyroidal tissues
ea0005p129
Identification of the ACTH receptor in the human pituitary and its loss of expression in pituitary adenomas
ea0005p130
The presence of ghrelin protein in the rat hypothalamus and the effect of ghrelin on corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) release from rat hypothalamic explants pituitary tumours
ea0005p131
Pituitary tumor transforming gene upregulates its binding factor PBF in vitro
ea0005p132
Insulin-like growth factor binding protein-3 (IGFBP-3) expression in the caecum and rectum of patients with and without acromegaly
ea0005p133
Expression of IGF-I in normal and malignant breast tissue and its association with tumour size
ea0005p134
Expression of IGFBP-3 mRNA in breast cancer in relation to clinical phenotype
ea0005p135
Methylation status and iodide uptake
ea0005p136
Prolactinoma volume and serum prolactin level: Evidence for the 'silent lactotroph' tumour
ea0005p137
Lipocortin-1 expression within normal and abnormal endometrium
ea0005p138
Co-regulators SRC-1 and SMRT interact with ER-alpha and ER-beta in human breast cancer
ea0005p139
Pituitary irradiation for recurrent steroid-responsive hypophysitis in three patients
ea0005p140
Abnormal expression of 11beta-hydroxysteroid dehydrogenase 2 in primary cultures of human pituitary adenomas
ea0005p141
Cell cycle dysregulation in parathyroid adenoma and carcinoma
ea0005p142
Transcriptional regulation by PEA3 in human breast cancer
ea0005p143
Metaiodobenzylguanidine scintigraghy (MIBG) and familial screening are not useful in phaeochromocytoma
ea0005p144
Molecular genetic diagnosis for disorders of calcium metabolism
ea0005p145
Expression of somatostatin receptors in proliferating and quiescent endothelial cells
ea0005p146
Insulinoma, diabetes and islet cell amyloid polypeptide
ea0005p147
A TSH response to a single octreotide test dose predicts a long term response to somatostatin analogue therapy in patients with a TSH-secreting pituitary adenoma
ea0005p148
Usefulness of growth hormone response to a test dose of subcutaneous octreotide in predicting longer-term response to the drug. Poor responses predict the need for adjuvant therapy to achieve 'safe' growth hormone levels
ea0005p149
Expression of vascular endothelial growth factor and its receptors in human anterior pituitary adenomas
ea0005p150
IGF-I inhibits COX-2 function in primary colonic biopsies of patients with acromegaly
ea0005p151
Can petrosal sinus ACTH and prolactin responses to CRH help localize the tumour in Cushing's disease due to pituitary microadenomas?
ea0005p152
A rapid method for analysing serum pro-insulin-like growth factor-II (pro-IGF-II) in patients with non-islet cell tumour hypoglycaemia (NICTH)
ea0005p153
A new role for the endocrine nurse within a multidisciplinary approach to neuroendocrine tumours
ea0005p154
Transsphenoidal surgery for acromegaly in Wales: Results based on stringent criteria of remission
ea0005p155
Carney complex type 1 gene (PRKAR1A) expression and sequence analysis in sporadic somatotroph and other pituitary tumours
ea0005p156
Elevated alpha fetoprotein levels in association with a metastatic neuroendocrine tumour
ea0005p157
Retrospective audit of care of patients undergoing pituitary surgery in Plymouth
ea0005p158
Lymphocytic adenohypophysitis occurring simultaneously with an ACTH secreting adenoma
ea0005p159
Double trouble. Dual pathology and false positive as well as false negative imaging in a man with phaeochromocytoma and hypogonadism
ea0005p160
Growth and Development
Testosterone enhances the effect of growth hormone (GH) to increase IGF-I but exerts an anabolic effect that is independent of GH action
ea0005p161
GATA3 missense mutation disrupts interaction with Friend of GATA 2 (FOG2) and causes the hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome
ea0005p162
Identification of GATA3 zinc finger 1 residues that are important for interactions with friend of GATA 2 (FOG2)
ea0005p163
A potential role for human securin/PTTG in the developing human fetal brain
ea0005p164
A unique sequence element that silences the growth hormone receptor (GHR) pseudoexon
ea0005p165
A novel mutation within the conserved eh-1 domain of HESX1 causes evolving CPHD due to the loss of interaction with the co-repressor TLE1
ea0005p166
The use of a specific questionnaire to assess quality of life in growth hormone deficient adults
ea0005p167
Differential regulation of the ghrelin promoter in WRL68 and HEK293 cells
ea0005p168
Expression and distribution of the prolactin-receptor in healthy, fibrotic and cirrhotic liver in rats and humans
ea0005p169
Regulation of Wolffian duct development in patients with complete androgen insensitivity syndrome
ea0005p170
The effect of chronic administration of recombinant (human) leptin on leptin and uncoupling protein (UCP) 2 mRNA in neonatal pigs
ea0005p171
Adults with partial growth hormone (GH) deficiency have an adverse body composition
ea0005p172
The effect of chronic administration of recombinant (human) leptin on the growth performance of neonatal pigs
ea0005p173
The effect of maternal dietary supplementation during late gestation on the growth performance of intra-uterine growth restricted (IUGR) pigs
ea0005p174
The use of combined GHRH and arginine test in the diagnosis of growth hormone deficiency in successfully treated acromegalics
ea0005p175
Cessation of growth hormone (GH) results in loss of lean body mass and reduced accrual of bone mass in adolescents with severe GH deficiency- 2 year follow up
ea0005p176
Neuroendocrinology and Behaviour
Galanin-like peptide interactions with leptin and GnRH
ea0005p177
Insulin sensitivity improves in patients with acromegaly converted from depot octreotide (Sandostatin LAR) to pegvisomant
ea0005p178
Intracerebroventricular ghrelin injection acutely stimulates food intake and inhibits luteinising hormone secretion in sheep
ea0005p179
Intra-hypothalamic gene transfer of cocaine and amphetamine regulated-transcript results in increased food intake and weight gain
ea0005p180
A randomised double-blind cross-over study of GH treatment in patients over 60 years
ea0005p181
Hypopituitarism following cranial irradiation for non-pituitary brain tumours
ea0005p182
Serum leptin, insulin, IGF-1 levels and body composition in partially and fully recovered patients with anorexia nervosa
ea0005p183
Differential effects of the route of testosterone administration on GH sensitivity and bone mineral density in hypopituitarism
ea0005p184
Abnormal endocrine tests in chronic pain require investigation and are not the result of opioid analgesia
ea0005p185
Effect of the novel somatostatin ligand, SOM230, on rat amp human anterior pituitary hormone secretion
ea0005p186
Pituitary apoplexy: A review of presentation, management and outcome
ea0005p187
Treating hyperprolactinaemia: Where to draw the line?
ea0005p188
Treatment outcome in acromegaly: Results from the Beaumont Hospital pituitary database
ea0005p189
Single centre audit of surgical outcome in acromegaly
ea0005p190
Problematic development of an immunometric assay for cocaine and amphetamine regulated transcript (CART) (55-102) peptide fragment
ea0005p191
Audit of quality of life in individuals who have undergone treatment for pituitary tumours over the past ten years at a single neurosurgical centre
ea0005p192
Reproduction
Maternal and neonatal outcomes after conception during cabergoline therapy for hyperprolactinaemia
ea0005p193
Insulin sensitivity in polycystic ovary syndrome-influence of peroral versus transdermal estrogen treatment
ea0005p194
Oxygen tension regulates placental 11beta-hydroxysteroid dehydrogenase type 2
ea0005p195
Clinical features of patients with macroprolactinaemia
ea0005p196
Hypoxia influences steroid and nitric oxide production in swine granulosa cells
ea0005p197
Effect of aroclor 1242 (PCB) on the reproductive function of adult male rhesus monkey (Macaca mulatta)
ea0005p198
Treatment of hypogonadotropic hypogonadism in women with neuroendocrine disorders
ea0005p199
Biological variation of free androgen index and bioavailable testosterone in PCOS: Implications for estimation of hyperandrogenaemia
ea0005p200
Screening for iron deficiency and anaemia in adults with Turner syndrome
ea0005p201
Complications of testosterone replacement in men with primary and secondary hypogonadism
ea0005p202
A more rigorous laboratory definition of macroprolactinaemia with clinical significance
ea0005p203
The effect of insulin-like growth factor-I (IGF-I) on initiation of human follicle growth in vitro
ea0005p204
Effects of CAG repeat expansion of the androgen receptor and its truncation on neural and non-neural cells
ea0005p205
Sexual dimorphism in fetal testosterone output in the silver fox
ea0005p206
Polycystic ovary syndrome (PCOS) has a significant negative impact on health-related quality of life (HRQoL)
ea0005p207
Pharmacokinetics and tolerability of a new a bioadhesive buccal testosterone tablet in testosterone deficient men
ea0005p208
Immunopurification of gonadotrophin surge-attenuating factor (GnSAF) bioactivity
ea0005p209
Comparison between azoospermic responders and oligozoospermic non-responders to sex steroidal contraception: A pharmacogenetics study examining the androgen receptor, CYP17, LHbeta and 5alpha-reductase-2 genes
ea0005p210
1,25-Dihydroxyvitamin D3 has a direct effect on steroid production from human theca cells
ea0005p211
Evidence for the use of metformin in women with polycystic ovary syndrome
ea0005p212
Testosterone pellet implants - an acceptable mode of androgen replacement
ea0005p213
Investigating germ cell development and differentiation in the human fetal testis
ea0005p214
Steroids
11Beta-hydroxysteroid dehydrogenase in human fibroblasts: Expression and regulation depends on tissue of origin
ea0005p215
Adipocyte size increases with BMI, but is unrelated to 11 beta-hydroxysteroid dehydrogenase type 1 expression
ea0005p216
Interactions between 11beta-hydroxysteroid dehydrogenase type 1 and 5beta-reductase
ea0005p217
Studies on functional activity of human ERbeta wild type and variant isoforms
ea0005p218
Mutagenesis studies on recombinant human 11beta-hydroxysteroid dehydrogenase type 1
ea0005p219
The relationalship of on-admission plasma cortisol to outcome in critical illness: a longitudinal prospective study
ea0005p220
CYP7B catalyses the 7alpha-hydroxylation of dehydroepiandrosterone in human prostate
ea0005p221
In vitro expression of human aldosterone synthase and 11-beta hydroxylase
ea0005p222
Excretion of the urinary metabolite of deoxycortisol is heritable and influenced by polymorphic variation at the CYP11B2 (aldosterone synthase) locus
ea0005p223
Differential regulation of vitamin D receptor and its ligand in human dendritic cells: A paracrine mechanism for regulation of antigen presentation
ea0005p224
High prevalence of low testosterone levels in men with coronary heart disease and an association with hypertension and obesity - The South Yorkshire study
ea0005p225
Identification of glucocorticoid target genes in human subcutaneous and omental adipose tissue using microarray analysis
ea0005p226
The 5' untranslated region of the rat glucocorticoid receptor contains elements important for cell-specfic promoter activity and glucocorticoid regulation
ea0005p227
Activation of the hypothalamic-pituitary-adrenal axis in adult women with low birthweight
ea0005p228
Regulation of aldosterone synthase (CYP11B2) gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II
ea0005p229
Beneficial affects of regular exercise: Is it all in the hormones?
ea0005p230
Development of a mouse hypertension model induced by aldosterone excess
ea0005p231
Urinary 18-hydroxycortisol: diagnostic utility of three methods compared
ea0005p232
In vitro synthesis of 18-hydroxycortisol (18-OH-F) and 18-oxocortisol (18-oxo-F); clues to their origin in normal human subjects
ea0005p233
Aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) gene expression in the normal and failing rat heart
ea0005p234
Cardiovascular risk assessment in bodybuilders abusing anabolic steroids
ea0005p235
Regulation of the human 11beta-hydroxysteroid dehydrogenase gene by glucocorticoids
ea0005p236
Cortisol metabolite excretion and 11-hydroxysteroid dehydrogenase type 1 activity are strongly heritable in man
ea0005p237
Contrasting acute and chronic changes in glucocorticoid action during high fat feeding in rats
ea0005p238
Effect of dietary sodium manipulation on aldosterone synthase (CYP11B2) gene expression in the rat cardiovascular system
ea0005p239
Is the cortisol day curve a useful tool?
ea0005p240
Urinary steroid hormone metabolites in patients with porphyrias
ea0005p241
Functional analysis of the N/C interactions in the AR
ea0005p242
Insulin sensitivity and hypoglycaemic susceptibility in children with endocrinopathies reflects the underlying hormone deficiency and treatment regimen
ea0005p243
Bilateral massive adrenal enlargement in a poorly treated adult patient with salt losing congenital adrenal hyperplasia
ea0005p244
Audit of adrenal vein sampling for primary aldosteronism
ea0005p245
Testosterone reduces free radical release from human monocytes
ea0005p246
Can random urine samples substitute for 24 hour collections for steroid profiling?
ea0005p247
A non-invasive test of mild glucocorticoid resistance
ea0005p248
Mutations in the HSD11B2 gene causing AME in the Oman population
ea0005p249
Isolated ACTH deficiency precipitated by silent thyroiditis presenting as acute metabolic acidosis
ea0005p250
Macroprolactinoma and pituitary dependent Cushing's syndrome: An unusual combination with response to dopamine agonist therapy
ea0005p251
The influence of anticoagulant preservatives, time and posture in renin measurements and estimation of aldosterone to renin ratio (ARR)
ea0005p252
Assessment of antiandrogenic activity in a range of environmental contaminants
ea0005p253
Thyroid
Thyroid hormone receptor (TR) activity is modulated by TRdeltabeta3 in a cell-, response element-, and TR isoform-specific manner
ea0005p254
Preliminary evidence for genetic heterogeneity in the autoimmune polyendocrinopathy and enteropathy syndrome (IPEX)
ea0005p255
The type II and III iodothyronine deiodinase enzymes are expressed in differentiating growth plate chondrocytes
ea0005p256
Does iodide modulate the biological outcome of activating thyrotropin receptor mutations?
ea0005p257
The W546X mutation of the thyrotropin receptor gene: Potential major contributor to thyroid dysfunction in a caucasian population
ea0005p258
The expression of apoptotic genes in autoimmune thyroid diseases
ea0005p259
Iodide effects on iodide transport and organification in human thyroid cells in vitro
ea0005p260
The epidemiology of thyroid cancer in Scotland, 1960 - 1999
ea0005p261
The controlled antenatal thyroid screening study (CATS) - first observations
ea0005p262
Cardiac autonomic function in hyperthyroidism
ea0005p263
Is the thyroglobulin gene a susceptibility locus for autoimmune thyroid disease in the UK?
ea0005p264
Assessment of UK caucasian allele frequencies of known TNF-alpha polymorphisms and their association with Graves' disease
ea0005p265
Psychological well-being in patients on 'adequate' doses of L-Thyroxine
ea0005p266
Does HLA-DRB1-DQA1-DQB1 genotype contribute to chronic autoimmune thyroiditis development in adult patients with diabetes mellitus Type 1?
ea0005p267
A managed clinical network for thyroid disease
ea0005p268
Somatostatin receptor expression in thyroid disease
ea0005p269
Adequacy of information delivered to patients during consultation for thyrotoxicosis
ea0005p270
Serum TSH and thyroid autoantibodies in thyroidal and extrathyroidal disease
ea0005p271
Comparison of simultaneous ultrasonography and radio-isotope scanning in hyperthyroid patients as compared with radio-isotope scanning alone
ea0005p272
Conventional withdrawal of thyroid suppression in differentiated thyroid carcinoma: How frequently are adequately raised TSH levels attained?
ea0005p273
High prevalence of ANCA in patients with Graves' disease treated with thionamides
ea0005p274
Lack of association of the interleukin 4 receptor gene with Graves' disease in the UK
ea0005p275
Does an eosinophil/monocyte ratio help to differentiate between types of thyrotoxicosis?
ea0005p276
Acute metabolic effects of high dose intravenous methylprednisolone therapy in patients with thyroid-associated ophthalmopathy
ea0005p277
Graves' disease presenting in the third trimester of pregnancy
ea0005p278
Outcome of carbimazole, radioactive iodine and subtotal thyroidectomy in the treatment of Graves' disease at Alnour Hospital in Saudi Arabia
ea0005p279
Homocysteine in subclinical hypothyroidism, a risk factor for atherosclerosis?
ea0005p280
Novartis Award Posters
Expression of adiponectin protein in human fat: the effect of type 2 diabetes and obesity
ea0005np1
Abnormalities of thyroid function in the POMC-null mouse
ea0005np2