Endocrine Abstracts (2003) 5 P181

A randomised double-blind cross-over study of GH treatment in patients over 60 years

PM Mah1, SJ Walters1, JD Newell-Price1, J Webster1, A Doane1, V Ibbotson1, JP Hosker2, TH Jones3, KK Ho4, R Eastell1 & RJ Ross1

1Sheffield University, Sheffield, UK; 2Doncaster Royal Infirmary, Doncaster, UK; 3Barnsley General Hospital, Barnsley, UK; 4The Garvan Institute of Medical Research, Sydney, Australia.

AIM: To assess efficacy of GH replacement and safety of stopping treatment in patients aged over 60 years.
METHODS: GH-deficient patients were started on GH 0.13 miligram per day and the dose titrated over 4 months to a serum IGF-1 in the upper half of the age-related normal range. After 4 months titration, patients were randomised to either continuing GH or placebo in a double-blind, cross-over study with 2 x 4 month periods of either GH or placebo treatment.
RESULTS: 14 patients (9 men) completed the study; median (range) age 69.5 (63-77) years, and GH dose 0.27 (0.13-0.8) miligram daily. Where no period effect existed results for patients are grouped together as either GH or placebo phase. Mean plus/minus SEM truncal fat mass decreased from 15.9 plus/minus 1.2 kilogram to 14.5 plus/minus 1.0 kilogram during 4 months titration (p=0.002), there was no further change during the GH phase but truncal fat increased during placebo treatment (p=0.014). Total lean mass increased from 48.1 plus/minus 2.2 kilogram to 49.7 plus/minus 2.4 kilogram (p=0.002) at 4 months, remained the same during GH and decreased to 48.4 plus/minus 2.3 kilogram during placebo (p=0.0003). Serum osteocalcin increased from 21.9 plus/minus 2.7 microgram per litre to 27.4 plus/minus 3.2 microgram per litre (p=0.045) at 4 months, remained elevated at 31.6 plus/minus 4.2 microgram per litre during GH and fell to 22.6 plus/minus 3.3 microgram per litre during placebo (p=0.012). QOL (AGHDA) improved in the 7 patients going from placebo to GH, 11 plus/minus 3 to 7 plus/minus 2 (p=0.017).
CONCLUSIONS: In older GH deficient patients GH treatment reduced truncal fat, increased lean body mass and increased bone turnover. These effects reversed on stopping GH therapy.

Article tools

My recent searches

No recent searches.