Endocrine Abstracts (2003) 5 P183

Serum leptin, insulin, IGF-1 levels and body composition in partially and fully recovered patients with anorexia nervosa

M Djurovic1, M Petakov1, S Damjanovic1, S Pekic1, B Glisic2, D Miljic1, M Doknic1, C Dieguez3, F Casanueva4 & V Popovic1

1Institute of Endocrinology, University Clinical Center, Belgrade, Yugoslavia; 2Clinic of Rheumatology and Allergology, VMA, Belgrade, Yugoslavia; 3Department of Physiology, Endocrine Section, Santiago de Compostela, Spain; 4Department of Medicine, Endocrine Section, Santiago de Compostela, Spain.

The variables which might affect the reproductive function in recovered patients with anorexia nervosa (AN) were investigated. We studied 12 patients with partially (n=6) and fully recovered AN (n= 6). They were matched for age (22.5 plus/minus 1.8 vs. 23.2 plus/minus 1.7 yrs; p>0.05), body weight (50.3 plus/minus 2.1 vs. 56.7 plus/minus 2.3kg; p>0.05) and BMI (19.7 plus/minus 0.2 vs. 20.3 plus/minus 0.6 kg/m2, p>0.05). Partially recovered AN were amenorrhoeic while fully recovered had at least 6 regular cycles. Pooled serum leptin, LH, FSH, insulin and IGF-1 levels were determined. Body fat (%) and bone mineral density were measured by dual energy x-ray absorbtiometry. No significant differences in serum leptin levels (7.2 plus/minus 1.2 vs. 7.3 plus/minus 1.1ng/ml; p>0.05), FSH levels (8.8 plus/minus 1.5 vs. 6.0 plus/minus 0.9mU/l; p>0.05), insulin levels (10.6 plus/minus 0.6 vs. 11.8 plus/minus 1.9mU/l; p>0.05), IGF-1 levels (32.4 plus/minus 4.3 vs. 28.4 plus/minus 4.0nmol/l; p>0.05), percentage of body fat (29.5 plus/minus 1.1 vs. 31.8 plus/minus 1.6%; p>0.05), year of onset of AN (16.5 plus/minus 1.0 vs. 19.8 plus/minus 1.9yrs; p>0.05) and in the duration of recovered body weight (1.8 plus/minus 0.4 vs. 1.2 plus/minus 0.3yrs; p>0.05) were found between the two defined cohorts. Significant differences were found in serum LH levels (1.2 plus/minus 0.2 vs. 3.8 plus/minus 0.9mU/l; p<0.05), duration of amenorrhoea (5.17 plus/minus 1.2 vs. 1.9 plus/minus 0.6yrs; p<0.05) and AP spine bone density (0.97 plus/minus 0.03 vs. 1.2 plus/minus 0.05gr/cm2; p<0.05). In conclusion, neither leptin, insulin and IGF-1 levels nor BMI or percentage of body fat appeared as significant determinants or predictors of the menstrual status in recovered AN. A possible explanation may lie in the CNS programmes which are still inactive or are inhibited or in low fat caloric intake in these patients.

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