The variables which might affect the reproductive function in recovered patients with anorexia nervosa (AN) were investigated. We studied 12 patients with partially (n=6) and fully recovered AN (n= 6). They were matched for age (22.5 plus/minus 1.8 vs. 23.2 plus/minus 1.7 yrs; p>0.05), body weight (50.3 plus/minus 2.1 vs. 56.7 plus/minus 2.3kg; p>0.05) and BMI (19.7 plus/minus 0.2 vs. 20.3 plus/minus 0.6 kg/m2, p>0.05). Partially recovered AN were amenorrhoeic while fully recovered had at least 6 regular cycles. Pooled serum leptin, LH, FSH, insulin and IGF-1 levels were determined. Body fat (%) and bone mineral density were measured by dual energy x-ray absorbtiometry. No significant differences in serum leptin levels (7.2 plus/minus 1.2 vs. 7.3 plus/minus 1.1ng/ml; p>0.05), FSH levels (8.8 plus/minus 1.5 vs. 6.0 plus/minus 0.9mU/l; p>0.05), insulin levels (10.6 plus/minus 0.6 vs. 11.8 plus/minus 1.9mU/l; p>0.05), IGF-1 levels (32.4 plus/minus 4.3 vs. 28.4 plus/minus 4.0nmol/l; p>0.05), percentage of body fat (29.5 plus/minus 1.1 vs. 31.8 plus/minus 1.6%; p>0.05), year of onset of AN (16.5 plus/minus 1.0 vs. 19.8 plus/minus 1.9yrs; p>0.05) and in the duration of recovered body weight (1.8 plus/minus 0.4 vs. 1.2 plus/minus 0.3yrs; p>0.05) were found between the two defined cohorts. Significant differences were found in serum LH levels (1.2 plus/minus 0.2 vs. 3.8 plus/minus 0.9mU/l; p<0.05), duration of amenorrhoea (5.17 plus/minus 1.2 vs. 1.9 plus/minus 0.6yrs; p<0.05) and AP spine bone density (0.97 plus/minus 0.03 vs. 1.2 plus/minus 0.05gr/cm2; p<0.05). In conclusion, neither leptin, insulin and IGF-1 levels nor BMI or percentage of body fat appeared as significant determinants or predictors of the menstrual status in recovered AN. A possible explanation may lie in the CNS programmes which are still inactive or are inhibited or in low fat caloric intake in these patients.
24 - 26 Mar 2003
British Endocrine Societies