Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2004) 7 P52

BES2004 Poster Presentations Diabetes, metabolism and cardiovascular (43 abstracts)

The IGF system influences prevalence of the metabolic syndrome in a population with high rates of cardiovascular disease

AH Heald 1 , SG Anderson 2 , A Vyas 2 , J Patel 2 , KW Siddals 1 , JK Cruickshank 2 & JM Gibson 2


1Department of Endocrinology and Diabetes, Hope Hospital, Salford, UK; 2Clinical Epidemiology Group, University of Manchester Medical School, Manchester, UK.


Introduction

The metabolic syndrome is associated with an increased risk of cardiovascular disease and diabetes. The insulin-like growth factor (IGF) system has been implicated in the pathogenesis of cardiovascular disease and glucose intolerance. We have previously shown that a low IGFBP-1 concentration coupled with a low circulating IGF-I predicts worsening glucose tolerance. In this study we further investigated relationships between the IGF-system and the metabolic syndrome in an ethnic group with especially high risk of cardiovascular disease.

Methods

394 individuals of Gujarati origin were studied and anthropometry, fasting plasma insulin, glucose, lipids, IGF-I, IGFBP-1 and IGFBP-3 measured. 58 subjects were defined as having the metabolic syndrome. This was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria.

Results

Age-adjusted circulating IGFBP-1 was significantly lower in the metabolic syndrome (35.5 (23.2, 47.7) mcg/l vs 46.7 (42.3, 51.0) mcg/l); F=8.9, P=0.003 as was IGF-I (104.4 (89.1, 119.7) vs 121.5 (116.0, 127.0) ng/ml)); F=4.2; P=0.04 and IGFBP-3; F=3.0, P=0.02. Conversely fasting insulin was higher in the metabolic syndrome (14.7 (12.8, 17.0) vs. 10.8 (10.0, 11.6) pmol/l); F=12.6; p=0.004. A univariate logistic regression showed that individuals with the lowest tertile of circulating IGF-I and IGFBP-1 below the median had a 10-fold increase likelihood of having the metabolic syndrome compared with those with the highest tertile of IGF-I and IGFBP-1 above the median (OR=10.7; P<0.05).

Conclusion

The combination of a low IGF-I and low IGFBP-1 is strongly correlated with the presence of the metabolic syndrome providing further evidence for a role for the IGF-system in the pathogenesis of cardiovascular disease.

Volume 7

23rd Joint Meeting of the British Endocrine Societies with the European Federation of Endocrine Societies

British Endocrine Societies 

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