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Volume 7
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BES2004
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23rd Joint Meeting of the British Endocrine Societies with the European Federation of Endocrine Societies
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0055 SFEEU2018
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0050 SFEBES2017
0049 ECE2017
0048 SFEEU2017
0047 Theranostics2016
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0045 BSPED2016
0044 SFEBES2016
0043 WCTD2016
0042 Androgens2016
0041 ECE2016
0040 ESEBEC2016
0039 BSPED2015
0038 SFEBES2015
0037 ECE2015
0036 BSPED2014
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0034 SFEBES2014
0033 BSPED2013
0032 ECE2013
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0030 BSPED2012
0029 ICEECE2012
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0027 BSPED2011
0026 ECE2011
0025 SFEBES2011
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Summary
Abstracts
Contents
Plenary Lectures
Society for Endocrinology Transatlantic Medal Lecture
Adipose tissue as an endocrine organ
ea0007s1
Society for Endocrinology Transatlantic Medal Lecture
ea0007s1biog
Clinical Endocrinology Trust Visiting Professor Lecture
Prediction and prevention of autoimmune thyroid disease
ea0007s2
Clinical Endocrinology Trust Visiting Professor Lecture
ea0007s2biog
Society for Endocrinology Dale Medal Lecture
Corticotropin releasing factor (CRF) family of ligands and their receptors
ea0007s3
Society for Endocrinology Dale Medal Lecture
ea0007s3biog
British Thyroid Association Pitt Rivers Lecture
Are thyroid hormone receptors good or bad for you?
ea0007s4
British Thyroid Association Pitt Rivers Lecture
ea0007s4biog
Clinical Endocrinology Trust Lecture
Cycling into trouble
ea0007s5
Clinical Endocrinology Trust Lecture
ea0007s5biog
Symposia
Endocrinology of obesity
Learning from experiments of nature
ea0007s6
Uncovering the genetic causes of common obesity
ea0007s7
Gut feeling
ea0007s8
Current approaches, future therapies
ea0007s9
Actions of insulin in non-classical target issues
Insulin signalling through PI 3-kinase
ea0007s10
Insulin regulation of pancreatic beta cells
ea0007s11
Insulin effects on cell signalling and nitric oxide synthesis in vascular endothelium
ea0007s12
Insulin action in the ovary
ea0007s13
Pituitary adenomas
Somatostatin and dopamine receptors in vitro
ea0007s14
Natural history of prolactinomas: lessons after withdrawal of long-term cabergoline
ea0007s15
Clinical markers of aggressive behaviour in non-functioning pituitary adenomas
ea0007s16
The extracellular calcium-sensing receptor in endocrine tissues
The calcium-sensing receptor and disorders of calcium-sensing
ea0007s17
Extracellular calcium as direct modulator of bone function
ea0007s18
Calcium sensing and bone development
ea0007s19
Neural migration in neuroendocrine systems
Recent advances in the understanding of GnRH neuronal migration in mammals
ea0007s20
GnRH neuronal Ontogeny - lessons from the investigation of Kallmann's Syndrome
ea0007s21
Overview of neuronal migration and axonal guidance. The role of the extracellular matrix
ea0007s22
Recent advances in pituitary development
ea0007s23
Hair: too little, too much
Androgen-dependent human hair growth: a biological paradox
ea0007s24
Gene regulation and the developing hair follicle
ea0007s25
The clinical management of Hirsutism: evidence based practice
ea0007s26
Molecular basis of thyroid disease
Role of cytokines and lymphocytes in Graves' disease
ea0007s27
Gene linkage and association studies in autoimmune thyroid disease
ea0007s28
Glycoprotein hormone receptors: from disease to structure and function
ea0007s29
Thyroid cancer molecular genetics: new oncogenes offer potential therapeutic targets
ea0007s30
Joint BES and EFES symposium: Neuroactive steroids: implications for disease and healthy ageing
Effects of neuroactive steroids on myelination
ea0007s31
Glial cells as mediators of the neuroprotective effects of oestrogen in the central nervous system
ea0007s32
Oestrogen and stroke: the potential for harm as well as benefit
ea0007s33
Sexual dimorphism and neuroprotection by sex steroids in an animal model of Parkinson's disease
ea0007s34
Clinical Management Workshops
Electrolyte disturbances
Cerebral salt wasting
ea0007s35
Unexplained hyponatraemia - diagnosis strategies
ea0007s36
Potassium homeostasis: the renal perspective
ea0007s37
Insulin delivery systems
Pancreatic islet transplantation
ea0007s38
Continuous glucose monitoring and pump technology
ea0007s39
Insulin analogues in diabetes mellitus
ea0007s40
When and how to remove the overactive parathyroid
When and how to remove the overactive parathyroid
ea0007s41
Imaging and diagnosis in parathyroid disease
ea0007s42
Focus Session
Focused Science Session
Monitoring the dynamic of interaction between the insulin receptor and protein tyrosine phosphatase-1B in living cells using BRET (bioluminescence resonance energy transfer)
ea0007s43
Nurses Session
Congenital adrenal hyperplasia
Congenital adrenal hyperplasia
ea0007s44
Assessing the need for an interpreter in families of children with CAH from an ethnic background
ea0007s45
Congenital Adrenal Hyperplasia - the nurses' perspective
ea0007s46
Young Endocrinologists Workshop
How to compete for grant funding
How to compete for grant funding
ea0007s47
A good academic CV
ea0007s48
Experience with applications for fellowships
ea0007s49
Molecular Endocrinology Workshop
Molecular Endocrinology Workshop
Mammalian RNA interference pathways
ea0007s50
Oral Communications
Reproduction
Allopregnanolone is involved in reduced HPA axis responses to immune challenge in late pregnancy
ea0007oc1
Gonadotrophs in annexin 1 knockout mice demonstrate enhanced secretory activity by structural analysis
ea0007oc2
Decidual activation of vitamin D3 - a novel immunomodulatory mechanism in early gestation
ea0007oc3
An anti-inflammatory role for progesterone at the human ovarian surface?
ea0007oc4
Orlistat and metformin are equally beneficial in reducing hyperandrogenaemia in polycystic ovarian syndrome
ea0007oc5
Effect of a high n-6 polyunsaturated fatty acid (PUFA) diet on COX expression and PGE2 synthesis in the ovine amnion during gestation
ea0007oc6
Placental endokinins may play a paracrine role on the placental vasculature
ea0007oc7
Effect of maternal dexamethasone treatment on hepatic and renal type I 5'-monodeiodinase activity and plasma triiodothyronine concentration in fetal sheep
ea0007oc8
Development and growth
The expression of monocarboxylate transporter 8, as a specific thyroid hormone transporter in human fetal brain and placenta: the effects of intrauterine growth restriction (IUGR)
ea0007oc9
Key mitotic regulators securin and separase in the human fetal brain
ea0007oc10
KAL-1 and KAL-2 ontogeny and in vitro function in human GnRH-1 developing system
ea0007oc11
Alterations of the somatotrophic axis in the obese agouti (Ay/a) mouse
ea0007oc12
A novel GH variant (Ile179Met) exhibits a decreased ability to activate the ERK pathway
ea0007oc13
The susceptibility of growth hormone missense variants to proteolytic degradation
ea0007oc14
Internalization of the GH antagonist pegvisomant
ea0007oc15
Responsiveness to growth hormone (GH) is increased in obesity
ea0007oc16
Thyroid
Thyroid hormone (T3) activates fibroblast growth factor (FGF) receptor signalling in bone
ea0007oc17
Biological consequences of gain-of-function thyrotropin receptor (TSHR) mutant expression in adipose tissue
ea0007oc18
PBF predicts recurrence in thyroid cancer and potentiates the actions of PTTG in vitro
ea0007oc19
Steroid modulation of peripheral cytokine expression: increased resistance to dexamethasone and progesterone inhibition of type 1 CD4+ response in autoimmune thyroiditis
ea0007oc20
Gender, age, goitre type and serum TSH level predict thyroid neoplasia in 1500 patients with thyroid enlargement investigated by FNAC
ea0007oc21
Defining genetic predictors for the development of Graves' disease in young females
ea0007oc22
Endocrine tumours
Expression of vitamin D metabolism and signalling components in breast tumours compared to paired normals
ea0007oc23
Microarray analysis of IGF-I mRNA positive and negative breast tumours
ea0007oc24
PPAR gamma expression in pituitary tumours
ea0007oc25
Mechanisms of HER2 resistance in endocrine tumours
ea0007oc26
Gamma knife sterotactic radiosurgery for acromegaly
ea0007oc27
Biochemical and genetic screening in isolated and familial MEN1
ea0007oc28
Clinical experience of intra-arterial calcium gluconate-stimulated hepatic venous sampling in the localisation of insulinomas
ea0007oc29
Effect of human growth hormone in haemato-oncology patients receiving intensive chemotherapy. A double blind randomized, placebo-controlled study
ea0007oc30
Diabetes and metabolism
Inducing pancreatic beta cell regeneration; interactions of transcription factors and peptide growth factors
ea0007oc31
Function of the calcium-sensing receptor in insulin-secreting MIN6 cells and human islets of Langerhans
ea0007oc32
Dietary intake and the IGF-system: a study in two related populations with a markedly different dietary intake
ea0007oc33
POMC haploinsufficiency in mice can cause obesity and reduced adrenal function
ea0007oc34
Continuous subcutaneous administration of ghrelin results in accumulation of adipose tissue, independent of hyperphagia or body weight gain
ea0007oc35
Tissue-specific alterations of glucocorticoid metabolism in ob/ob mice
ea0007oc36
Resistin as an acute phase reactant and a positive mediator of IL-6 and TNF-alpha secretion in isolated human subcutaneous adipocytes
ea0007oc37
Bacterial and yeast co-expression studies reveal hexose-6-phosphate dehydrogenase to be a crucial regulator of 11beta-hydroxysteroid dehydrogenase type 1 oxoreductase activity
ea0007oc38
Poster Presentations
Bone
Failure to normalise PTH during the treatment of osteomalacia
ea0007p1
Does leptin regulate bone turnover in adult growth hormone deficiency?
ea0007p2
Oral bisphosphonates may reverse the decline in bone mineral density in adults with cystic fibrosis
ea0007p3
The role of the growth hormone-insulin-like growth factor-I (GH-IGF-I) axis in the aetiology of male idiopathic osteoporosis
ea0007p4
Growth hormone replacement is important for the restoration of PTH circadian rhythmicity in older adult growth hormone deficient patients
ea0007p5
Parathyroid hormone and phosphate circadian rhythms are altered in osteopaenic adult growth hormone deficient patients
ea0007p6
Transdermal testosterone replacement in men with evidence of borderline gonadal failure
ea0007p7
Application of new indices of bone activity for evaluation of the response to treatment of hyperthyroidism and Paget's disease
ea0007p8
Outcome of parathyroidectomy for primary hyperparathyroidism in 249 consecutive patients
ea0007p9
Inactivating progesterone metabolism in human osteoblasts
ea0007p10
Utility of biochemical screening in the context of evaluating patients with a presumptive diagnosis of osteoporosis
ea0007p11
Investigation of seasonal reference intervals for 25-Cholecalciferol (Vitamin D)
ea0007p12
The role of local corticosteroid generation in inflammation-associated bone loss
ea0007p13
Adenosine stimulates IL-6 but inhibits osteoprotegerin secretion by osteoprogenitor cells
ea0007p14
Growth retardation following prenatal GC exposure is more pronounced in the female offspring and is associated with raised serum IGF-1
ea0007p15
Comparative endocrinology
Developmental changes in gonadal and adrenal steroidogenesis in the blue fox (Alopex lagopus)
ea0007p16
An appraisal of biochemical assessment of hypogonadism and bio-available testosterone in adult men
ea0007p17
Usefulness of ultrasonography in girls with true precocious puberty before and after two years of treatment with an LH-RH analogue
ea0007p18
Changes in bone mineral density in response to growth hormone replacement in adults with isolated growth hormone deficiency compared with multiple pituitary hormone deficiencies
ea0007p19
Cytokines and growth factors
Glucocorticoids suppress macrophage migration inhibitory factor (MIF) expression in a cell-type specific manner
ea0007p20
Responsiveness to growth hormone throughout the menstrual cycle
ea0007p21
The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
ea0007p22
Effects of estrogen on leptin signalling and leptin-induced TNF-alpha production
ea0007p23
Excessive daytime sleepiness associated with hypercytokinaemia in POEMS
ea0007p24
Effects of long term growth hormone replacement on leptin and body composition in adult growth hormone deficiency
ea0007p25
GHR-GPI insertion into target CHO cell membranes
ea0007p26
Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour
ea0007p27
Adrenomedullin mRNA and peptide content are increased in skin following wounding
ea0007p28
Basic fibroblast growth factor (FGF2) in hypothalamus, neurohypophysis and choroid plexus: dehydration supports a putative linkage with arginine vasopressin and fluid balance
ea0007p29
Comparison of IL-1 alpha induced gene expression in normal human ovarian surface epithelial cells and ovarian cancer cells
ea0007p30
Thyroid hormone regulates heparan sulphate proteoglycans in the growth plate
ea0007p31
Urinary human chorionic gonadotrophin (hCG) associated proteins: isolation and characterisation by peptide identification mass spectrometry
ea0007p32
Diabetes, metabolism and cardiovascular
Non-alcoholic fatty liver disease among Saudi type-2 diabetics attending medical outpatient clinic
ea0007p33
The effect of DHT on the regulation of the renin angiotensin system in human abdominal subcutaneous adipocytes: implications for PCOS
ea0007p34
The effect of body mass index on duration of intensive care stay and in-hospital mortality after cardiac surgery in an Irish centre
ea0007p35
A7r5 rat aortic vascular smooth muscle cell apoptosis is reduced by testosterone
ea0007p36
Mitogen-induced apoptosis in A7r5 rat aortic vascular smooth muscle cells is not effected by testosterone
ea0007p37
Reduced insulin content and secretory capacity in the adult offspring of rats exposed to a high fat diet in pregnancy
ea0007p38
A randomised controlled trial of laser treatment among hirsute women with polycystic ovary syndrome
ea0007p39
Understanding the fetal origins of the metabolic syndrome and its amplification by obesity; high fat feeding potentiates the programming of hepatic insulin resistance by antenatal dexamethasone in rats
ea0007p40
The N363S polymorphism of the glucocorticoid receptor in South Asians in the North East
ea0007p41
PYY deficiency may reinforce obesity
ea0007p42
Improvements in glucose utilisation immediately following exercise in patients with and without type 2 diabetes seem to be independent of improvements in insulin sensitivity
ea0007p43
Effect of size at birth on glucose tolerance in pigs at 5 months of age
ea0007p44
Transcriptional interference by novel human PPARgamma mutants associated with lipodystrophic insulin resistance
ea0007p45
Single nucleotide polymorphisms within oxidative stress genes affect arterial compliance: gene function relationships
ea0007p46
A novel non-steroidal inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 improves features of metabolic syndrome in murine disease models
ea0007p47
Mechano-receptors and cell-to-cell communication in the human collecting duct: functional involvement of TRPV4 and connexin-43
ea0007p48
Increased C-jun N terminal kinase (JNK) activity may link insulin resistance and inflammation in human central obesity
ea0007p49
Circulating pro-inflammatory cytokines and epicardial expression of resistin and TNF-alpha are increased in patients with cardiovascular disease
ea0007p50
Relation of plasma homocysteine levels to atherosclerotic vascular disease and inflammation markers in type 2 diabetic patients
ea0007p51
The IGF system influences prevalence of the metabolic syndrome in a population with high rates of cardiovascular disease
ea0007p52
Investigation and management of severe hyponatraemia - cause for concern?
ea0007p53
TLR mediated activation of the innate immune response in human adipocytes with associated down-regulation of adiponectin secretion and elevated TNF-alpha and IL-6 levels
ea0007p54
Expression of mineralocorticoid effector mechanisms in renal biopsies of patients with severe proteinuria
ea0007p55
Testosterone regulates renal expression of the alpha-subunit of the epithelial sodium channel (alpha-ENaC)
ea0007p56
Protective effects of phytoestrogens against oxidative stress in human endothelial cells
ea0007p57
Targeted RNA interference to selectively modulate expression of PPARgamma2 and 1 isoforms
ea0007p58
Quantitative analysis of glucose and insulin sensing genes in the hypothalami of Zucker Diabetic Fatty (ZDF) rats
ea0007p59
Increased aromatase expression in human subcutaneous adipose tissue in obesity
ea0007p60
PPARgamma2 and RXRalpha are required for the transcriptional activation of the melanocortin 2 receptor during adipocyte differentiation
ea0007p61
Physiological concentrations of testosterone inhibit extracellular calcium entry via voltage-gated calcium channels in A7r5 vascular smooth muscle cells
ea0007p62
Testosterone inhibits Ca2+ currents in A7r5 vascular smooth muscle cells, and in HEK293 cells stably expressing the alpha1C subunit of L-type Ca2+ channels (CaV1.2) and alpha1H T-type Ca2+ channels (CaV3.2)
ea0007p63
High prevalence of low testosterone in men with type 2 diabetes and an association with glycaemic control and obesity
ea0007p64
Leptin increases lipid peroxidation in the mouse brain
ea0007p65
Testosterone-induced vasodilatation of isolated human mesenteric and pulmonary resistance arteries is independent of the vascular endothelium
ea0007p66
Evaluation of the in-house radioimmunoassay method for peptide YY (PYY)
ea0007p67
Diastolic blood pressure, waist circumference and cardiovascular disease in patients with obesity and type 2 diabetes
ea0007p68
Diabetes risk in Turner syndrome - a unique metabolic defect?
ea0007p69
The metabolic syndrome is common in type 2 but uncommon in type 1 diabetes mellitus
ea0007p70
Diabetes knowledge deficits in adolescents and young adults with type 1 diabetes mellitus
ea0007p71
Maternal serum hCG binding to immobilised wheat germ agglutinin in women with and without type 1 diabetes mellitus
ea0007p72
A comparison of the impact of exercise in Asian and Caucasian women with Polycystic Ovary Syndrome
ea0007p73
Exercise instruction in patients with type 2 diabetes and obesity: a randomised controlled trial
ea0007p74
Characteristics and outcome of severe hyponatraemia - a case control study
ea0007p75
Endocrine tumours and neoplasia
Galectin-3 staining of benign and malignant thyroid lesions - is it a useful diagnostic tool?
ea0007p76
A case of severe Cushing's disease in a treated non-functioning pituitary adenoma with difficult medical management
ea0007p77
Proliferation of colon cancer cell line and parathyroid hormone-related peptide gene
ea0007p78
Is there an ultra-short loop feedback of ACTH on itself?
ea0007p79
FSH-secreting pituitary gonadotroph adenoma producing ovarian hyperstimulation
ea0007p80
Deacetylating agents as mediators of iodide uptake and efflux in thyroid and breast
ea0007p81
Over-expression and over-activation of protein kinase B/Akt in human pituitary tumours
ea0007p82
An audit of acromegaly in North-East Scotland: increased use of medical therapy enables preservation of pituitary function
ea0007p83
The cyclin E specific F-box protein archipelago is over-expressed in pituitary tumours
ea0007p84
Urinary free metadrenalines provide the best diagnostic biochemical test for phaeochromocytoma; experience in a tertiary care centre
ea0007p85
A clinic for multiple endocrine neoplasia highlights needs for greater family awareness of type 1 MEN and for genetic testing of other family members
ea0007p86
Association between serum insulin-like growth factor-1 and serum growth hormone levels across an oral glucose tolerance test in assessing disease activity in acromegaly
ea0007p87
Ovarian stromal luteoma - a rare cause of postmenopausal virilization diagnosed by selective ovarian venous sampling
ea0007p88
The GnRH test in the assessment of patients with pituitary and parapituitary lesions. Results of a 5-year retrospective study
ea0007p89
Adrenal incidentalomas and insulin resistance - a simple coincidence or a complex syndrome?
ea0007p90
Should post hypophysectomy patients be discharged on steroids? The use of 0900h-cortisol measurements as a screening test for pituitary-adrenal dysfunction
ea0007p91
Inhibition of cell proliferation, but lack of antiangiogenic effect on GH-secreting pituitary adenomas treated with Lanreotide
ea0007p92
A new operation for adrenal pathology: laparoscopically-assisted mini-adrenalectomy
ea0007p93
Somatostatin and VEGF expression within the larynx
ea0007p94
The effects of surgery and tamoxifen on serum IGF-I and IGFBP3 levels in breast cancer
ea0007p95
Results of different primary treatment procedures for acromegalic patients
ea0007p96
Transcriptional silencing of the IGF-I receptor inhibits proliferation of MCF-7 breast cancer cells
ea0007p97
Diagnosis - 'query acromegaly'
ea0007p98
Factors determining remission of microprolactinomas after dopamine agonist withdrawal
ea0007p99
Pituitary tumor transforming gene (PTTG) regulates downstream angiogenic genes in thyroid cells
ea0007p100
Clinical studies of patients with neuroendocrine tumours (NETs)
ea0007p101
IGF-I and IGFBP-3 mRNA expression in tamoxifen-resistant, recurrent breast cancers
ea0007p102
IGF-I and IGFBP-3 mRNA expression in tamoxifen-resistant, recurrent breast cancers
ea0007p103
A somatostatin analogue and octreotide exert anti-proliferative effects on colonic cancer cells
ea0007p104
Imbalance between separase and securin levels in thyroid and other malignancies
ea0007p105
The effects of ghrelin on IGF-I expression in normal and malignant breast tissue explants
ea0007p106
Prevalence of hypopituitarism in patients with prolactin-secreting pituitary microadenomas
ea0007p107
Systemetic dose extension of octreotide LAR - the importance of individual tailoring of treatment
ea0007p108
Investigation into the efficacy of routine octreotide scanning in post-operative acromegalics with refractory disease
ea0007p109
Octreotide dependency: a cautionary tale
ea0007p110
Expression of SSTR subtypes (1-5) in normal and malignant colonic tissue
ea0007p111
Metastatic glucagonoma de-differentiated to an insulinoma: response to embolization
ea0007p112
Long acting somatostatin analogues administered by practice nurses: an audit
ea0007p113
Long-term remission following withdrawal of dopamine agonist therapy in subjects with microprolactinomas
ea0007p114
The effects of pituitary tumours on cognitive function
ea0007p115
Novel actions of the anti-estrogen faslodex at the estrogen receptor
ea0007p116
Managing prolactinomas: our experience at Preston
ea0007p117
Expression and localisation of BAD and Akt in human breast cancer cell lines pre- and post-irradiation
ea0007p118
Bilateral laparoscopic adrenalectomy for ACTH-dependent Cushing's syndrome
ea0007p119
BIM-23244, a somatostatin analogue with high affinity for somatostatin receptors 2 and 5, inhibits endothelial proliferation in vitro
ea0007p120
Discrepancies between current consensus criteria for cure after transsphenoidal surgery for acromegaly
ea0007p121
Retrospective audit of bilateral adrenalectomies with reference to the occurrence of Nelson's syndrome
ea0007p122
Parathyroid imaging: which modality best inform surgical treatment?
ea0007p123
The efficacy of an octreotide test dose to predict the outcome of treatment for acromegaly with somatostatin LAR
ea0007p124
The changing patterns of presentation and treatment of acromegaly in the UK as reflected by the UK National Acromegaly Database
ea0007p125
Improved quality of life (QOL) with normalisation of IGF-I in patients with acromegaly
ea0007p126
24-hour ambulatory blood pressure monitoring (ABPM) in patients with acromegaly and the value of clinic blood pressure measurements
ea0007p127
Regional variations in colonic neoplasia in acromegaly
ea0007p128
Growth and development
The effect of nutritional deprivation in late gestation on uncoupling protein-2 mRNA abundance in the ovine neonatal lung
ea0007p129
Possible factors determining individual sensitivity to GH replacement therapy; a KIMS database analysis
ea0007p130
Do prolonged courses of testosterone affect final height in extreme maturational delay?
ea0007p131
The hydration fraction of lean body mass (LBM) does not change during six months physiological GH replacement in adults with severe GHD
ea0007p132
The relationship between maternal thyroid status in the antenatal period and new born growth measurements: a cohort study
ea0007p133
Quality of life (QOL) improvement, during physiological GH replacement in severely GHD adults, is not explained by favourable changes in body composition
ea0007p134
Leptin and leptin receptor localisation in endocrine glands of fetal sheep
ea0007p135
The value of the TRH test in the assessment of hypothalamic-pituitary disorders in children
ea0007p136
Frequency of single nucleotide polymorphisms in the GHRH receptor gene in short children
ea0007p137
A dominant negative thyroid hormone receptor (TR) beta1 mutant enhances N-Tera-2 (NT2) cell proliferation
ea0007p138
Transdermal testosterone application: pharmacokinetics and effects on pubertal status, short-term growth and bone turnover
ea0007p139
Long-term association of the Y chromosome and blood pressure in boys at the pre- and post-pubertal periods
ea0007p140
Growth hormone replacement reduces circulating inflammatory markers, blood pressure and large artery compliance but does not affect resistance artery function in adult hypopituitary patients
ea0007p141
Regulation of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1) paracrine pathway by thyroid hormone (T3) during bone development
ea0007p142
Pregnancy-induced plasticity in rat pituitary: a morphological and endocrine study of somatotroph and lactotroph function
ea0007p143
Gene expression in peripheral blood mononuclear cells: the effect of GH in a GH-deficient child
ea0007p144
Neuroendocrinology and behaviour
The insulin tolerance test (ITT) in clinical practice: the experience of a busy pituitary unit
ea0007p145
Cardiovascular risk burden in adult patients with hypopituitarism
ea0007p146
Incorporating social preferences in the measurement of QoL outcomes in growth hormone deficiency (GHD) in adults
ea0007p147
Neuroendocrine abnormalities in the acute phase of traumatic brain injury
ea0007p148
Investigating the potential role of melanocortin receptor 5 in the rodent adrenal gland
ea0007p149
Quality of life deficit in hypopituitary adults with growth hormone deficiency (GHD): comparison of age-sex matched patient data and a UK population survey
ea0007p150
Downward resetting of the osmotic threshold for thirst in patients with syndrome of inappropriate antidiuretic hormone
ea0007p151
Nephrogenic diabetes insipidus in the mouse does not deplete vasopressin neurons or activate oxytocin neurons
ea0007p152
Comparison of anterior pituitary annexin 1 expression in male/female and old/young Long Evans and Brattleboro rats
ea0007p153
Prevalence of hypopituitarism in survivors of traumatic brain injury
ea0007p154
The effect of oestrogen replacement therapy (ORT) on growth hormone (GH) dose; KIMS database perspective
ea0007p155
Metastatic glucagonoma transforming to an insulinoma
ea0007p156
Investigation of the hypothalamo-pituitary-adrenal axis in patients with irritable bowel syndrome
ea0007p157
DNA microarray analysis of NECA action in a pituitary folliculostellate cell line
ea0007p158
Imaging of the pituitary is indicated in marginal hyperprolactinaemia (lt1000 milliunits per litre) to detect microadenoma
ea0007p159
Effects of melatonin on catecholaminergic neurotransmitters in brain areas regulating food intake in the male rat
ea0007p160
The acute octreotide suppression test is useful in predicting long-term responses to depot somatostatin analogue injections in patients with active acromegaly
ea0007p161
Effects of melatonin on the regulation of leptin production in rat anterior pituitary cells
ea0007p162
Primary therapy with somatostatin analogues in acromegaly does not restore orderly GH secretion
ea0007p163
Down-regulation of neurotrophin receptor expression limits the regenerative potential of injured CNS neurons
ea0007p164
Functional interactions between anosmin-1, heparan sulphate and urokinase-type plasminogen activator and the pathogenesis of X-linked Kallmann's Syndrome
ea0007p165
Are cortisol responses to psychological stress related to size at birth in humans?
ea0007p166
Addition of dopamine agonists to somatostatin analogue therapy improves biochemical control of acromegaly
ea0007p167
Variability in GH assays undermines the value of consensus criteria for the diagnosis of adult GH deficiency and acromegaly
ea0007p168
The role of the melanocortin 5 receptor in the hypothalamic regulation of appetite and pituitary function
ea0007p169
Reproduction
Leptin, inhibin B and LH levels in patients with anorexia nervosa
ea0007p170
Regulation of ovine placentome morphology by cortisol in late gestation
ea0007p171
The effect of insulin-like growth factor I (IGF-I) on initiation of follicle growth in normal and polycystic ovaries in vitro
ea0007p172
Specificity and clinical utility of methods for the detection of macroprolactin
ea0007p173
New approach in treatment of hyperandrogenism with triiodothyronine
ea0007p174
Effect of supplementing the maternal diet with excess energy during late gestation on body fat deposition, reproductive performance and plasma insulin concentration in pigs
ea0007p175
The effects of thyroid hormone on cytokine-induced proliferation in human trophoblast cells
ea0007p176
Oral tibolone combined with testosterone as a potential male contraceptive: pharmacodynamic study examining additive effects in suppression of pituitary-testicular axis
ea0007p177
Routine screening for macroprolactin
ea0007p178
Microarray studies of human ovarian surface epithelium exposed to an inflammatory stimulus
ea0007p179
Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists increase glucose metabolism in a human granulosa cell line (HGL-5)
ea0007p180
The CAM technique and follicle development
ea0007p181
Paint thinner exposure inhibits testosterone synthesis and secretion in a reversible manner in the rat
ea0007p182
Ultrastructural and immunohistochemical examination of effects of leptin on testis in mice
ea0007p183
Stimulatory effects of ghrelin on spontaneous contractions in the rat myometrium
ea0007p184
The expression of somatostatin receptors in human granulosa cells
ea0007p185
Anti-Mullerian hormone (AMH) protein expression in normal and polycystic human ovaries
ea0007p186
Effects of oral nomegestrol acetate, a 19 norprogesterone-derived progestin on the reproductive axis and lipids in men
ea0007p187
Follow up of women with Turner's syndrome in an adult endocrine clinic
ea0007p188
TGFbeta signaling pathways in LHRH neurons
ea0007p189
Mullerian Inhibiting Substance is elevated in obese women with PCOS and is suppressed by metformin treatment
ea0007p190
Protein kinase (PKA)-independent but cAMP-dependent regulation of progesterone secretion by luteinizing human granulosa cells
ea0007p191
Intramuscular testosterone (T) undecanoate for the treatment of male hypogonadism: a parallel-group randomised open-label pharmacokinetic study
ea0007p192
Neurokinin B-like immunoreactivity can be detected in peripheral tissues in the non-pregnant rat
ea0007p193
Biochemical evidence for follicular maturation (1): changes of inhibins and activin-A levels in follicular fluid from matched follicles
ea0007p194
Analysis of hCG beta core fragment glycosylation in normal and aberrant pregnancy by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry
ea0007p195
Biochemical evidence for follicular maturation (2): production of progesterone, inhibins and activin-A by granulosa cells from size matched follicles
ea0007p196
Clinical interpretation of macroprolactin reports
ea0007p197
Steroids
Conventional corticosteroid replacement therapy may overtreat adult hypopituitary patients with partial ACTH deficiency
ea0007p198
Glucocorticoids contribute to the heritability of leptin in Scottish adult female twins
ea0007p199
Patients' knowledge and satisfaction on the management of steroid replacement therapy
ea0007p200
The origin of 18-hydroxycortisol and 18-oxocortisol in man
ea0007p201
Sweat patch cortisol - a new screen for Cushing's syndrome
ea0007p202
Dehydroepiandrosterone sulphate (DHEAS) inhibits growth of human vascular endothelial cells
ea0007p203
Inhibition of steroid 5beta-reductase by bile acids
ea0007p204
Adequacy of patient understanding about glucocorticoid replacement
ea0007p205
Regulation of 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat adrenal gland and central nervous system by ACTH and dexamethasone
ea0007p206
Local inflammation activates the renal vitamin D hormonal system in human kidneys
ea0007p207
The testicular feminised mouse: physiological testosterone replacement
ea0007p208
The effect of adrenalectomy on 11beta-hydroxylase(CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the hippocampus
ea0007p209
Quantitative analysis of plasma 17-hydroxyprogesterone using isotope dilution mass spectrometry
ea0007p210
Spironolactone interference in the immunoassay of androstenedione
ea0007p211
Role of PPAR-gamma receptor agonist therapy in two patients with newly diagnosed pituitary-dependent Cushing's syndrome
ea0007p212
Local regeneration of glucocorticoids by 11betaHSD-1 within the vessel wall modulates angiogenesis
ea0007p213
Lipopolysaccharide (LPS) stimulates cortisol secretion via toll-like receptors and COX-2 activation
ea0007p214
An AP-1-like site is required for basal activity of the murine ACTH receptor (MC2-R) promoter in Y1 cells
ea0007p215
The inhibition of human hair growth by 17beta-oestradiol using whole follicle organ cultures
ea0007p216
Molecular basis of a new form of congenital adrenal hyperplasia
ea0007p217
The impact of endogenous cortisone on bone and fat: demonstration of in vivo 11beta-hydroxysteroid dehydrogenase type 1 activity
ea0007p218
Hexose 6-phosphate dehydrogenase expression confers reductase activity upon 11 beta-HSD1 in adipose tissue
ea0007p219
Secretogogues induce transcription factor, SF-1 and co-activator, SRC-1 activity in the human adrenal gland
ea0007p220
Mineralocorticoid replacement in patients with primary hypoadrenalism; does plasma renin concentration help in practice
ea0007p221
A model for evaluating 11beta-hydroxysteroid dehydrogenase type 1 activity in ocular and orbital tissues
ea0007p222
11beta-hydroxysteroid dehydrogenase type 1 and the production of cerebrospinal fluid
ea0007p223
Reproducibility of cortisol day curve in monitoring patients on long-term Hydrocortisone Replacement Therapy
ea0007p224
Gene expression responses induced in kidney by aldosterone excess and salt
ea0007p225
Thyroid
Outcome of atrial fibrillation complicating hyperthyroidism
ea0007p226
No association of a polymorphism in the kozak sequence of the CD40 gene and Graves' disease in a UK Caucasian population
ea0007p227
Congenital hypothyroidism (CH) in the United Arab Emirates (UAE) - past, present and future
ea0007p228
Twenty-four hour hormone profiles of TSH, free T3 and free T4 in hypothyroid patients on combined T3/T4 therapy
ea0007p229
Thyroid hormones and TPO-antibodies in the cord blood of newborns
ea0007p230
Pretibial myxoedema as the first manifestation of Graves disease
ea0007p231
Thyroxine replacement monitoring using a computerised register: the North Trent experience
ea0007p232
Estimators of number- and volume-weighted mean volume of colloid in the thyroid gland of rats
ea0007p233
Adjunctive lithium improves outcome in patients given radioiodine for hyperthyroidism
ea0007p234
Evaluation of thyroid function in patients with chronic active HCV and HBV hepatitis treated with interferon-alpha
ea0007p235
Hypothyroidism is less frequent following radioactive iodine treatment for toxic nodular goitre than Graves' disease
ea0007p236
Seaweed as a model for iodide uptake and retention in the thyroid
ea0007p237
Multiple thyroid tumours
ea0007p238
Specific effect of thyrotropin on thyroglobulin and on the polypeptides distribution in cultured human thyroid cells
ea0007p239
Defining aetiological variants within the HLA class II region that lead to the development of Graves' disease
ea0007p240
The evaluation of arterial stiffness in subclinical hypothyroidism
ea0007p241
Premature birth and fetal growth retardation in nonautoimmune hyperthyroidism due to activating thyrotropin receptor gene mutation
ea0007p242
Controlled anti-natal thyroid screening study (CATS) - early results
ea0007p243
The expression of mRNA for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase) in the tissue of papillary thyroid carcinoma (PTC) and of medullary thyroid carcinoma (MTC) in humans
ea0007p244
Does thyroidectomy exacerbate or relieve the throat symptoms of globus pharyngeus?
ea0007p245
Electrocardiographic changes in patients with hypothyroidism
ea0007p246
Regulation of the angiopoietins in thyroid follicular cells
ea0007p247
Clinical case reports
X-linked hypopituitarism: clinical and biochemical features of a rare cause of short stature
ea0007p248
Cocaine use a risk factor for DKA
ea0007p249
Osteomalacia precipitated by growth hormone treatment in the adult: increased bone turnover unmasking occult vitamin D deficiency
ea0007p250
Adrenal insufficiency as the second clinical manifestation of the primary antiphospholipid antibody syndrome
ea0007p251
Paradoxical urine and plasma cortisol response to dexamethasone: probable Carney Complex with micronodular adrenal hyperplasia
ea0007p252
Myocardial infarction due to coronary artery spasm in a patient with thyrotoxicosis
ea0007p253
Puerperal hypoglycaemia in a young woman with type 1 diabetes mellitus
ea0007p254
Coeliac disease as a cause for delayed presentation of hypopituitarism
ea0007p255
Thyrotoxicosis due to Graves' disease in a patient on immunosuppressive therapy for psoriasis
ea0007p256
Transformation of a micro-prolactinoma to a macro-prolactinoma during pregnancy without symptoms or signs of pituitary enlargement: two case reports
ea0007p257
Severe hypercalcaemia in Graves' disease
ea0007p258
Diagnostic difficulty in differentiating between meningioma and pituitary adenoma
ea0007p259
Pitfalls in the management of hypocalcaemia: refractory hypocalcaemia after thyroidectomy not caused by postoperative hypoparathyroidism
ea0007p260
Hypothalamic cavernous haemangioma presenting with hypothalamic syndrome and secondary hypogonadism
ea0007p261
Acquired von Willebrand's disease secondary to autoimmune hypothyroidism
ea0007p262
A case of the pituitary resistance to thyroid hormone successfully treated with bromocriptine
ea0007p263
Hyponatremia and recurrent abdominal pain
ea0007p264
Cushing's disease and coexistent craniopharyngioma - report of a case
ea0007p265
Is there an association between serum calcium concentrations and endoscopic diagnosis in patients with dyspeptic symptoms?
ea0007p266
A vicious cycle of profuse diarrhoea, hypokalaemic renal failure and elevated gut hormone levels unmasking a neuroendocrine pancreatic tumour
ea0007p267
The pituitary lesion that escaped the knife
ea0007p268
Primary and secondary hypogonadism in systemic sarcoidosis: indications for corticosteroid therapy
ea0007p269
Truly rare - a true hermaphrodite
ea0007p270
Normoprolactinaemic galactorrhoea in a male-to-female transsexual
ea0007p271
Myxoedema coma with pericardial effusion and respiratory arrest in a 59-year-old woman
ea0007p272
Development of GH secretion and malignant change in a giant prolactinoma
ea0007p273
Crooke Cell Adenoma: case report of a rare but aggressive tumour
ea0007p274
Bilateral laparascopic adrenalectomy as a palliative procedure for resistant ectopic ACTH producing small cell carcinoma of the lung: a case report
ea0007p275
The evolution of diabetes insipidus in a man with multiple pathology in the sacrum
ea0007p276
A diagnostic pitfall: concomitant occurrence of macroprolactinaemia and a non-secreting pituitary adenoma
ea0007p277
Primary hypopituitarism as a first presentation of sarcoidosis - 2 case reports
ea0007p278
A novel 17 alpha hydroxylase mutation (CYP 17) associated with a pelvic germ cell tumour
ea0007p279
Surgical treatment of children with neonatal severe hyperparathyroidism
ea0007p280
Recognition of Smith Lemli Opitz syndrome by characteristic steroids
ea0007p281
Pituitary sarcoidosis with disappearing mass: case report
ea0007p282
A case of undiagnosed multiple endocrine neoplasia type 2B (MEN 2B)
ea0007p283
Late recovery of pituitary function following traumatic brain injury
ea0007p284
Hypocalcaemia and hypomagnesaemia as a complication of Cronkhite-Canada syndrome
ea0007p285
Porphyria cutanea tarda complicated by primary hepatocellular carcinoma
ea0007p286
Post menopausal virilisation
ea0007p287
Testosterone-replacement stimulated hyperprolactinaemia
ea0007p288
A case of non-classical 11-beta hydroxylase deficiency
ea0007p289
Spontaneously resolving hypopituitarism followed by primary adrenal lymphoma-related phenomena?
ea0007p290
A case of adrenal failure secondary to metastasis from a breast angiosarcoma
ea0007p291
A case of severe congenital adrenal hyperplasia treated successfully with laparoscopic bilateral adrenalectomy
ea0007p292
Ectopic pancreas presenting as dyspepsia
ea0007p293
Ectopic ACTH syndrome presenting with epistaxis and hypertension: a case report
ea0007p294
Tuberculous thyroiditis - a rare cause of hyperthyroidism
ea0007p295
Multiple endocrine disturbances in a 15-year old girl with intranial tuberculomas
ea0007p296
Gestational diabetes insipidus, severe hypernatremia and hyperemesis gravidarum in a primigravid pregnancy
ea0007p297
The use of 17 hydroxyprogesterone and short synacthen tests in patients diagnosed with polycystic ovarian syndrome
ea0007p298
Human chorionic gonadotrophin responsive adrenal cortical carcinoma and Cushing's Syndrome in pregnancy
ea0007p299
Severe reactive hypoglycaemia alleviated by acorbose administration
ea0007p300
Complete right vocal cord paralysis: a very rare complication of radioiodine therapy for hyperthyroidism
ea0007p301
Radiotherapy is more effective than growth hormone in treating haemangiopericytoma induced hypoglycaemia
ea0007p302
Short stature in thalassemia major: multiple aetiologies
ea0007p303
Clinical practice
An audit to evaluate the second radioiodine challenge scan in patients with thyroid cancer
ea0007p304
Audit of follow-up for patients on long-term amiodarone and the incidence of amiodarone induced thyrotoxicosis
ea0007p305
Audit of thyroid surgery in a district general hospital
ea0007p306
Incidence and prevalence of thyroid dysfunction in the general population of Tayside, Scotland
ea0007p307
A change in role for the endocrine nurse specialist - a survey
ea0007p308
Mutation testing in multiple endocrine neoplasia (MEN1): an audit
ea0007p309
Novartis Award Posters
KAL-1 and KAL-2 ontogeny and in vitro function in human GnRH-1 developing system
ea0007np1
Bacterial and yeast co-expression studies reveal hexose-6-phosphate dehydrogenase to be a crucial regulator of 11beta-hydroxysteroid dehydrogenase type 1 oxoreductase activity
ea0007np2