Searchable abstracts of presentations at key conferences in endocrinology
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23rd Joint Meeting of the British Endocrine Societies with the European Federation of Endocrine Societies

Plenary Lectures

Society for Endocrinology Dale Medal Lecture

ea0007s3 | Society for Endocrinology Dale Medal Lecture | BES2004

Corticotropin releasing factor (CRF) family of ligands and their receptors

Vale W , Bale T , Li C , Reyes T , Perrin M , Jamieson P , Chen A , Brar B , Vaghan J , Rivier J

CRF mediates numerous complementary stress-related endocrine (HPA), autonomic and behavioral responses. CRF antagonists block many stress-induced responses in experimental animals. Furthermore, perturbations of the CRF system or HPA have been reported in human affective disorders. CRF acts through two Class B G protein coupled receptors derived from two genes, which have alternative splice variants and distinct expression patterns. Mice null for CRF-R1 exhibit reduced basal an...

ea0007s3biog | Society for Endocrinology Dale Medal Lecture | BES2004

Society for Endocrinology Dale Medal Lecture

Vale W

Wylie Vale, Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, San Diego, California, USA Abstract Wylie Vale is the Helen McLoraine Professor of Molecular Neurobiology and Head of the Clayton Foundation Laboratories for Peptide Biology at the Salk Institute for Biological Studies, where he is currently Chair of the Faculty. He is also an Adjunct Professor of Medicine at the Un...