Searchable abstracts of presentations at key conferences in endocrinology
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23rd Joint Meeting of the British Endocrine Societies with the European Federation of Endocrine Societies

Molecular Endocrinology Workshop

Molecular Endocrinology Workshop

ea0007s50 | Molecular Endocrinology Workshop | BES2004

Mammalian RNA interference pathways

McManus M , Sharp P

Now that the sequence of the entire human genome is known and the number of predicted genes is estimated, the next challenge is to assign biological function to each of the genes. A new and very powerful way for exploring gene function is offered by RNA interference (RNAi). In this method, the introduction of double-stranded RNA identical in sequence to that of the gene of interest inactivates the gene or, more precisely, 'interferes' with its function.T...