Endocrine Abstracts

At present, the blue fox is extensively studied in connection with the process of domestication and there is a need for a better understanding of endocrine processes associated with reproductive and stress-response development in this species. Plasma concentrations of testosterone, oestradiol, ACTH and cortisol, gonadal in vitro production of testosterone and oestradiol and adrenal in vitro production of cortisol were measured by RIA in foetal (47-48 days of pregnancy, n=69), ...

Hypogonadism is difficult to confirm with standard assays. A large proportion of testosterone (T) is bound to sex hormone binding globulin (SHBG) and is biologically inert. Accurate measures of free and biological-available-testosterone (Bio-T) are largely unavailable. In this study we compared formulae calculated from the total testosterone (TT) and SHBG in their ability to predict hypogonadism and/or Bio-T.TT and SHBG were determined by ELISA and Bio-T...

INTRODUCTION: The usefulness of suppressing true precocious puberty (TPP) in order to improve the final height is still under discussion and may depend on early diagnosis and timely treatment. The purpose of our study was to evaluate the effects of the treatment on uterine and ovarian morphology before and after two years of therapy.METHODS: U/S was performed on 15 girls with TPP whose mean age was 6.92plus/minus SD1.09 years at the time of diagnosis. Al...

The contribution of conventional hormone replacement to the clinical features attributed to adult growth hormone deficiency (GHD) is poorly defined. We measured baseline bone mineral density (BMD/DXA) at the lumbar spine and femoral neck in patients with isolated GHD (IGHD, 16 patients, 14 female, 4 childhood onset, mean age 39, range 19- 63 years) and patients with multiple pituitary hormone deficiencies (MPD, 135 patients, 94 female, 14 childhood onset, mean age 44, range 19...