Endocrine Abstracts

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There are just over 600 children in the UK on renal replacement therapy, with an annual take-on rate of around 100. There are many more in chronic renal failure (CRF). The main complications are poor growth, renal osteodystrophy and an increased risk of cardiovascular disease in early adulthood, all of which are inter-related.The main player in renal osteodystrophy is hyperparathyroidism, which develops early in the course of CRF. PTH levels can be manip...

Critical illness due to sepsis, trauma, surgery, organ failure or burns is associated with dramatic effects on most hormonal axes. Complex changes occur at the hypothalamic, pituitary, circulatory and tissue levels of hormone action. In the early stages of critical illness these changes appear to be adaptive but this may not be the case in prolonged illness. Common problems faced by endocrinologists are the recognition of pre-existing endocrine disorders in critically ill pati...