Endocrine Abstracts

A complex network of cell-cell communication system by peptide hormones works for maintaining the mammalian homeostatic balance. To further clarify the intricate mechanisms of the regulation, it is important to discover unidentified bioactive peptides. For this purpose, we have established our own methods for isolating and sequencing of peptides in pico mole quantities. By using these methods, we discovered novel bioactive peptides such as neuromedins, three natriuretic peptid...

K Kangawa, National Cardiovascular Center Research Institute, Suita, Osaka, Japan AbstractDr Kangawahas discovered novel bioactive peptides by establishing his original method for exploring trace amounts of peptides in order to elucidate the mechanisms of intercellular communication. In the course of these studies, he discovered and determined the chemical structures of three natriuretic peptides: ANP (1984), BNP ...