Endocrine Abstracts

The goal of this study was to determine whether ghrelin increase the mean plasma concentration of thyroxine (T4), triiodothyronine (T3), growth hormone (GH), milk amount and constituents in the dairy goats. Animals were anesthetized throughout the surgery for stereotaxic methods and jugular wein cannulations. Nine goats were randomly divide into 3 groups. Each group received daily infusion of either 1 or 2 or 4 ug gherlin for 7 days into their third ventricle. Blood samples we...

Studies show men and women differ in their aptitude towards different cognitive tests, which may be attributable to hormonal differences. It has also been postulated that oestrogen has disease-assuaging properties in some mental illness. The aim of this study was to assess the Cambridge Neuropsychological Test Automated Battery (CANTAB) as a tool for measuring cognitive differences between the sexes.A total of 43 volunteers, 20 women and 22 men, aged bet...

Novel object discrimination is a widely used ethologically relevant working memory task. However, there is little information regarding gender differences in performance of this test. The aim of this study was to compare the performance of male and female rats in this task following increasing intertrial intervals.Subjects were 24 female and 24 male adult hooded-Lister rats (250±10 g) group housed under standard laboratory conditions. Testing consis...

The transcription factor, Steroidogenic factor-1 (SF-1/NR5A1) is the only specific marker of the VMH, to date. Total SF-1 deficiency results in defective VMH neuronal differentiation and architecture, and mice heterozygous for SF-1 (SF-1+/−), or conditionally depleted of SF-1 in the VMH show reduced levels of the neurotrophin Bdnf and an increased propensity for weight gain. Recent studies have suggested several putative SF-1 target genes in the VMH tha...