ea0010s10 | Non classical sites of action of classical hormones | SFE2005
, Sun L
, Onigata K
, Abe E
We have revisited the actions of hormones from the anterior pituitary, notably TSH, on bone and bone cells. Traditionally, the bone loss in hyperthyroidism has been attributed solely to elevated circulating levels of thyroid hormones. The role of TSH, which is reduced in all forms of hyperthyroidism, as well as during thyroxine suppressive therapy for thyroid cancer, has never been investigated. We found that haploinsufficiency of the TSH receptor in mice led to bone loss with...