Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 11 | ECE2006 | Next issue

8th European Congress of Endocrinology incorporating the British Endocrine Societies

Plenary Lecturers’ Biographical Notes

European Journal of Endocrinology Prize Lecture

ea0011s1 | European Journal of Endocrinology Prize Lecture | ECE2006

Evolutionary mechanisms of glycoprotein hormone receptors (TSHr, LH/CGr and FSHr) to cope with hCG in humans

Journal E

The glycoprotein hormones are proteins comprising a common alpha subunit and specific beta subunits having substantial sequence similarity. The glycoprotein hormone receptors (GPHr) (FSH, LH/CG and TSH receptors) present a bipartite structure, with a large extracellular domain (ECD) responsible for high affinity hormone binding and a carboxylterminal serpentine region, shared by G-protein-coupled-receptors (GPCRs), implicated in transmission of the activation signal. Mutagenes...