Searchable abstracts of presentations at key conferences in endocrinology
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8th European Congress of Endocrinology incorporating the British Endocrine Societies

Plenary Lecturers’ Biographical Notes

Psychological determinants of metabolic risk

ea0011s9 | Psychological determinants of metabolic risk | ECE2006

Rhabdomyolysis and other adverse effects of statins: what happens when we inhibit HMG CoA reductase

Law M

HMG CoA reductase, the rate-limiting enzyme in the mevalonate pathway, is 14 steps away from cholesterol synthesis. Statins dramatically reduce the serum concentration of LDL cholesterol by inhibiting this enzyme, but may similarly lower the concentration of many other compounds in the pathway, including ubiquinone (possibly the mechanism of statin-induced rhabdomyolysis though the evidence is far from conclusive). Certain drugs are important co-factors in statin-induced rhabd...