Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2006) 11 P211

ECE2006 Poster Presentations Comparative endocrinology (7 abstracts)

The patients with HIV lipodystrophy syndrome have lower total fat mass but similar free fat mass

P Freitas 1 , D Carvalho 1 , F Correia 1 , T Faria 2 , B Perez 2 , R Marques 3 , R Serrão 3 , J Pereira 2 , A Mota Miranda 3 & JL Medina 1

1Endocrinology Department, Hospital S. João, Porto, Portugal; 2Nuclear Medicine, Hospital S. João, Porto, Portugal; 3Infectious Disease Department, Hospital S. João, Porto, Portugal; 4University of Porto Medical School, Porto, Portugal.

Introduction: The highly active antiretroviral therapy (HAART) completely changed the natural history and body composition of the infected patients. The lipodystrophy syndrome of HIV-infected patients (IP) is characterized by fat mass redistribution in the limbs, face lipoatrophy and abdominal lipohypertrophy. Dual-energy x-ray absorptiometry scan (DEXA) and bioelectrical impedance (BIA) are techniques to determine body composition (BC).

Aims: Evaluate the BC in HIV-IP treated with HAART with (CL) and without clinical lipodystrophy (WCL).

Patients and methods: We studied 117 HIV-IP, 25 women and 92 men, by anthropometry, BIA (Tanita) and DEXA.

CL (n=82)WCL (n=35)P
Age (years)48.8±10.940.4±10.1<0.001
Duration of disease (years)8.6±4.16.5±3.3<0.05
Duration of treatment HAART (years)7.7±4.04.8±3.2<0.005
BMI (Kg/m2)24.4±3.825.9±4.9<0.05
Waist circumference (WC) (cm)90.2±10.292.6±13.2ns
Hip circumference (HC) (cm)91.9±7.199.0±8.4<0.001
Thigh circumference (TC) (cm)46.3±4.850.4±5.8<0.001
Total Fat Mass (TFM) (%) (BIA) (n=117)18.8±7.624.3±10.7<0.05
Total Fat Mass (TFM) (%) (DEXA) (n=83)15.2±8.927.2±10.8<0.001
Fat Free Mass (FFM) (Kg) (BIA) (n=117)53.3±7.453.4±8.6ns
Fat Free Mass (FFM) (Kg) (DEXA) (n=83)51.2±7.250.6±9.3ns
Total Body Water (Kg) (BIA) (n=117)39.0±5.439.1±6.3ns
To compare the variables we used Mann-Whitney test.

Results: The patients with CL had similar WC to WCL but lower HC and TC. In patients with CL we observed a % TFM significantly lower (BIA and DEXA) but similar FFM and TBW.

Conclusions: The patients with HIV-Lipodystrophy Syndrome had WC, FFM and TBW similar to the patients WCL. The TFM of the same patients is significantly reduced.

Volume 11

8th European Congress of Endocrinology incorporating the British Endocrine Societies

European Society of Endocrinology 
British Endocrine Societies 

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