Introduction: The highly active antiretroviral therapy (HAART) completely changed the natural history and body composition of the infected patients. The lipodystrophy syndrome of HIV-infected patients (IP) is characterized by fat mass redistribution in the limbs, face lipoatrophy and abdominal lipohypertrophy. Dual-energy x-ray absorptiometry scan (DEXA) and bioelectrical impedance (BIA) are techniques to determine body composition (BC).
Aims: Evaluate the BC in HIV-IP treated with HAART with (CL) and without clinical lipodystrophy (WCL).
Patients and methods: We studied 117 HIV-IP, 25 women and 92 men, by anthropometry, BIA (Tanita) and DEXA.
|CL (n=82)||WCL (n=35)||P|
|Duration of disease (years)||8.6±4.1||6.5±3.3||<0.05|
|Duration of treatment HAART (years)||7.7±4.0||4.8±3.2||<0.005|
|Waist circumference (WC) (cm)||90.2±10.2||92.6±13.2||ns|
|Hip circumference (HC) (cm)||91.9±7.1||99.0±8.4||<0.001|
|Thigh circumference (TC) (cm)||46.3±4.8||50.4±5.8||<0.001|
|Total Fat Mass (TFM) (%) (BIA) (n=117)||18.8±7.6||24.3±10.7||<0.05|
|Total Fat Mass (TFM) (%) (DEXA) (n=83)||15.2±8.9||27.2±10.8||<0.001|
|Fat Free Mass (FFM) (Kg) (BIA) (n=117)||53.3±7.4||53.4±8.6||ns|
|Fat Free Mass (FFM) (Kg) (DEXA) (n=83)||51.2±7.2||50.6±9.3||ns|
|Total Body Water (Kg) (BIA) (n=117)||39.0±5.4||39.1±6.3||ns|
|To compare the variables we used Mann-Whitney test.|
Results: The patients with CL had similar WC to WCL but lower HC and TC. In patients with CL we observed a % TFM significantly lower (BIA and DEXA) but similar FFM and TBW.
Conclusions: The patients with HIV-Lipodystrophy Syndrome had WC, FFM and TBW similar to the patients WCL. The TFM of the same patients is significantly reduced.
01 - 05 Apr 2006
European Society of Endocrinology