Endocrine Abstracts

Aim: To study the carbohydrate metabolism in patients with Itsenko-Kushing’s disease (IKD) and Itsenko-Kushing’s syndrome (IKS).

Materials and Methods: 23 patients with hypercorticism were investigated. From which in 8 patients IKD was diagnosed, and in 15 – IKS. In patients with IKD the amount of cortizol was at 8.00 – 273.3±56.8 ng/ml (N- 50–250 ng/ml); 20.00 – 343.3±43.8 ng/ml (N- 50–250 ng/ml); the value of adrenocorticotropic hormone was – 89.01±7.3 pg/ml (N- 4.7–41.0 pg/ml). In patients with IKS the amount of cortizol was at 8.00 – 246.3±23.8 ng/ml (N- 50–250 ng/ml); 20.00 – 287.7±32.5 ng/ml (N- 50–250 ng/ml); the value of adrenocorticotropic hormone was – 3.6±2.7 pg/ml (N- 4.7–41.0 pg/ml). For the study of the carbohydrate metabolism we determined the fasting glucose and glycosylated hemoglobin (HbA₁C).

Results: In patients with IKD the level of HbA₁C was >7.5 mcm/frghb (N- 3.5–7.5), and glucose ranged in – 120–150 mg/dl in 3 patients. In patients with IKS the HbA₁C was >7.5 mcm/frghb in 9 patients, and the glucose – >120 ng/dl in 12 patients. Against a background of the treatment of the primary disease the carbohydrate metabolism was normalized in 2 patients with IKD and in 10 patients with IKS. In the rest of the patients we observed the type 2 diabetes.

Conclusions: About the state of the carbohydrate metabolism we have to judge not only by the determination of the fasting glucose, but also by HbA₁C (every 3 month). The normalization of the carbohydrate metabolism is related with hypercorticism normalization.