Aim: To study the carbohydrate metabolism in patients with Itsenko-Kushings disease (IKD) and Itsenko-Kushings syndrome (IKS).
Materials and Methods: 23 patients with hypercorticism were investigated. From which in 8 patients IKD was diagnosed, and in 15 IKS. In patients with IKD the amount of cortizol was at 8.00 273.3±56.8 ng/ml (N- 50250 ng/ml); 20.00 343.3±43.8 ng/ml (N- 50250 ng/ml); the value of adrenocorticotropic hormone was 89.01±7.3 pg/ml (N- 4.741.0 pg/ml). In patients with IKS the amount of cortizol was at 8.00 246.3±23.8 ng/ml (N- 50250 ng/ml); 20.00 287.7±32.5 ng/ml (N- 50250 ng/ml); the value of adrenocorticotropic hormone was 3.6±2.7 pg/ml (N- 4.741.0 pg/ml). For the study of the carbohydrate metabolism we determined the fasting glucose and glycosylated hemoglobin (HbA1C).
Results: In patients with IKD the level of HbA1C was >7.5 mcm/frghb (N- 3.57.5), and glucose ranged in 120150 mg/dl in 3 patients. In patients with IKS the HbA1C was >7.5 mcm/frghb in 9 patients, and the glucose >120 ng/dl in 12 patients. Against a background of the treatment of the primary disease the carbohydrate metabolism was normalized in 2 patients with IKD and in 10 patients with IKS. In the rest of the patients we observed the type 2 diabetes.
Conclusions: About the state of the carbohydrate metabolism we have to judge not only by the determination of the fasting glucose, but also by HbA1C (every 3 month). The normalization of the carbohydrate metabolism is related with hypercorticism normalization.
01 - 05 Apr 2006
European Society of Endocrinology