Endocrine Abstracts (2006) 11 P552

Fourier transform infrared spectroscopy (FTIR) of parathyroid pathology

K Das, N Stone, C Kendall, C Fowler & J Christie-Brown

Gloucestershire Royal Hospital NHS Foundation Trust, Gloucester, Gloucestershire, United Kingdom.

Surgical management for parathyroid disease worldwide is on the rise. Hand in hand, parathyroid surgery has evolved from the classical bilateral approach to the more focussed unilateral approach. The failure rate in the best of hands continues to be 3–4% but this figure may rise as Minimally Invasive Surgical techniques are universally adopted.

Accurate pathological diagnosis to differentiate parathyroid adenomas from hyperplasia continues to be difficult for the pathologist and is essential for successful parathyroid surgery. We evaluated the ability of FTIR to accurately differentiate between parathyroid adenomas and hyperplasia and present our preliminary results. 8 glands were analysed, 4 hyperplasias and 4 adenomas.

The sensitivity of FTIR for adenomas was 99.25% and hyperplasias 99.17%, thus making it an excellent tool to differentiate the two.

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