Endocrine Abstracts (2006) 11 P565

Embryonic gene expression affected by different sodium concentrations

M Heydarpour & F Heydarpour


ZUMS, Zanjan, Iran.


Introduction: The type of Maternal electrolyte taken during prenatal period may change the homeostasis of body fluids which genetically sensitizes individuals during maturation. So in this experience, we studied the effects of different Nacl concentrations in distilled water used by pregnant rats on their offspring.

Method: Eight groups, each containing 6 Mature rats with 200 gr weight were selected, Each group contain 5 non pregnant rats and a male during the period of pre-pregnancy and till the end of pregnancy. Six concentration of salt 0.5, 1, 1.4, 1.6, 1.8 and 2 percent were used for six groups and the other test group used distilled water and control group used tap water of Isfahan. Birth weight, weight in third months and BP of infant were measured.

Result: Birth weight and weight in third month of infants whose mothers had used 0.5 and 1% salt solution showed an increase as compared with control group and BP showed a reduction but 1.4% and higher salt solution causes low birth weight and weight in third month and increases BP in infant rats.

Discussion: Nutrition with enough salt in prenatal period promote activation of a group of gene which causes an increase in birth weight and weight in third month and a reduction in BP and nutrition with excessive amount of salt promote another group of gene which promote a reduction in birth weight and weight in third month and an increase in BP.

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