Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 26 P734

ECE2011 Poster Presentations Diabetes (epidemiology, pathophysiology) (32 abstracts)

Does anxiety influence food preference and insulin resistance in healthy men?

Ludmila Brunerova 1, , Jana Potockova 2 , Jiri Horacek 3 & Michal Andel 2

1Mediscan, Prague, Czech Republic; 2II. Internal Department, Faculty Hospital Kralovske Vinohrady and 3rd Faculty of Medicine, Diabetologic Centre, Charles University, Prague, Czech Republic; 33rd Faculty of Medicine, Psychiatric Centre Prague, Charles University, Prague, Czech Republic.

Introduction: We tested our hypotheses that higher anxiety/depression scores can be connected with food preference of carbohydrates and higher insulin resistance.

Methods: We examined 42 healthy men (average age 43.5±7.4 years, average BMI 27.4±5.7 kg/m2). Study protocol included filling in the self-asssessing scores of anxiety (SAS) resp. depression (SDS), carbohydrate-craving questionnaire (CCQ); assessment of 3-days diet records, hyperinsulinemic euglycemic clamp on two levels of insulinemia (1 and 10 mU/kg per min) with calculation of glucose disposal resp. metabolic clearance rate of glucose for both insulin levels (M1, M2 resp. MCR1 a MCR2) and citalopram challenge test (infusion of 0.3 mg/kg of citalopram with measurement of prolactin levels in minutes: −30, −15, 0, 15, 30, 45, 60, 90, 120, 150 and with calculation of area under the curve for prolactin levels. Student’s t-test, Kolmogorov-Smirnov test and Spearman’s corelation coefficient were used for statistical analyses.

Results: We observed positive correlations between SAS resp. SDS scores and intake of monocarbohydrates in food: r=0.44, P=0.02; resp. r=0.4, P=0.03, but negative correlation between MCR2 and SAS resp. SDS in the whole studied group: r=−0.38, P=0.04; r=−0.04, P=0.03, whereas in the subgroup of insulin sensitive subjects MCR2 and SAS corelated positively: r=0.55, P<0.05. We did not find any relationship between response in citalopram challenge test and either food preference of carbohydrates or parametres of insulin resistance.

Conclucions: Subjects with higher depression/anxiety scores prefer more carbohydrates in the food. In general, subjects with higher depression/anxiety scores are more insulin resistant in comparison with those less anxious/depressive while the subjects from insulin sensitive subgroup seem to be more anxious than those insulin resistant. The study was supported by VZ MSM 0021620814.

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