Endocrine Abstracts (2006) 11 P672

Bone mass density in 180 women with premature ovarian failure

S Vujovic, M Stojanovic, Z Penezic, M Ivovic, M Kovacevic, B Barac, Lj Marina & M Drezgic


Institute of Endocrinology, Belgrade, Serbia, Yugoslavia.


Premature ovarian failure (POF) is characterized by amenorrhea, hypergonadotropism and hypoestrogensm in women under 40 years. Sex steroids play an important role in maintaining bone mass and cessation of ovarian function results in significant bone loss.

Objective: To evaluate bone mass density (BMD) and factors influencing it in women with POF.

Design & methods: First group of 144 women with spontaneous POF (I), 39.7±7.6 y’s old, BMI=29.4±2.1 kg/m and second group of 36 women with bilateral adnexectomy (II), 41±7.8 y’s, BMI=24.9±2.9 kg/m. Risk factors (eating habits, smoking, alcohol intake, training) were tested. FSH, LH, prolactin, estradiol, progesterone and testosterone were detected by RIA. BMD was measured at the lumbar spine by DEXA

Statistics: Kruskal-Wallis ANOVA, Chi-square test, Spearman’s correlation. Results: No significant difference was found for amenorrhoic period, menarche, W/H ratio. High correlation was found between physical training, non smoking, regular cycle, normal BMI and T score implying on the low risk for osteoporosis (P<0.01). The higher risk was found in the II group. According to amenorrhoic period (<5 y’s; 6–10; >11 y’s) T scores in I vs II group were: −1.6 vs −1.8; −1.8 vs −2.1; −1.9 vs −3.2.

Conclusions: Young women with POF need early education regarding on strategies to maintain their BMD and appropriate hormone replacement therapy in achieving better quality of life.

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