ECE2006 Poster Presentations Thyroid (174 abstracts)
Hashimoto’s thyroiditis in the children: clinical features at presentation
VT Skarpa , ED Kostakioti , AK Tertipi , PA Petrou , E Posnaghidou , M Anastasakou , P Papahilleos , A Papathanasiou & C Hadjiathanasiou
Children’s Hospital “P. & A. Kyriakou”, Athina, Greece.
Hashimoto’s thyroiditis (HT) is the most frequent thyroid disease in children, in areas of the world with sufficient iodine intake.
Aim: To study the clinical features of HT in children at presentation.
Material and method: We studied 99 children with HT, 76 (76.8%) girls and 23 (23.2%) boys, with mean chronological age 10.7±2.6 ys (3.2–15.6 ys). The diagnosis of HT was established from the high titers of antithyroid antibodies (aTPO-Ab, aTg-Ab) and the absence of other thyroid disease associated with positive antibodies. Thyroid volume was estimated with ultrasound, and compared to WHO reference values. T4 and TSH were measured in all children.
Results: Thirty six children (36.4%) were prepubertal and 63 (63.6%) pubertal. Euthyroidism was present in 70 (70.7%) children, subclinical hypothyroidism in 20 (20.2%), hypothyroidism in 6 (6.1%) and hyperthyroidism in 3 (3%). aTPO-Abs were positive in 78 (78.8%) and aTg-Abs in 82 (82.8%) children. In 6 (6.2%) children the thyroid volume by ultrasound was less than the 50th centile for their age, in 46 (46.4%), between the 50th and 95th centile and in 47 (47.4%) greater than the 95th centile. Girls significantly outnumbered boys, χ2=28.3, P<0.001.
Conclusion: HT in children usually presents with euthyroidism. Subclinical hypothyroidism is present in 1/5 of the children. Hypothyroidism and hyperthyroidism are rare at presentation. About half of the children present with significant increase in thyroid gland volume, greater than the upper range for their age.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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