Searchable abstracts of presentations at key conferences in endocrinology
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197th Meeting of the Society for Endocrinology

Oral Communications

Placenta, bone and genetics

ea0012oc9 | Placenta, bone and genetics | SFE2006

IGF acts through the IGF1R mediated PI3K pathway in first trimester human placenta to rescue cytotrophoblasts from apoptosis

Forbes K , Aplin JD , Westwood M

Conditions such as pre-eclampsia and intrauterine growth restriction highlight the importance of normal placental cell turnover for successful pregnancy outcome. In these conditions abnormal levels of proliferation and increased apoptosis have been reported; aberrations in components of the IGF axis have also been observed. IGFs regulate proliferation and survival in other cellular systems but their ability to influence human placental cell function remains to be established.<...

ea0012oc10 | Placenta, bone and genetics | SFE2006

The expression and regulation of the tachykinin (TAC) genes in the placenta

Page NM , Dakour J , Morrish DW

Tachykinins are a family of peptides comprising substance P, neurokinin B (NKB) and endokinin B (EKB) that are encoded on three separate genes, TAC1, 3 and 4, respectively. Traditionally classified as neurotransmitters the highest expression levels of EKB and NKB are found in the placenta, where, NKB has been implicated in pre-eclampsia (PE) and intrauterine growth restriction. We have conducted mRNA expression studies to look at the placental expression of each of the ...

ea0012oc11 | Placenta, bone and genetics | SFE2006

Effect of leptin on hepatic carbohydrate metabolism and insulin signalling proteins in fetal sheep

Forhead AJ , Lamb CA , Franko KL , Cripps RL , Ozanne S , Blache D , Fowden AL

Although leptin is important in the control of appetite and energy expenditure in adulthood, its actions before birth are unclear. This study investigated the effects of leptin on hepatic carbohydrate metabolism and insulin signalling in fetal sheep. Twelve sheep fetuses were chronically-catheterised at 115–120 d of gestation (term 145±2 d), and infused intravenously with saline (0.9% NaCl; n=6) or recombinant ovine leptin (0.5–1.0 mg/kg/d; Protein Labora...

ea0012oc12 | Placenta, bone and genetics | SFE2006

Physiological blockade of gut hormones increases food intake

Kokkinos A , Vincent RP , le Roux CW , Ghatei MA , Bloom SR

BackgroundAppetite is complex, however to address the obesity epidemic, therapeutic agents would have to significantly influence appetite. Currently the most effective treatment for obesity is bariatric surgery because it reduces hunger and increases satiety. The satiety gut hormones such as peptide YY (PYY) and glucagon like peptide 1 (GLP-1) reduce appetite and food intake. Compared to lean and obese subjects, exaggerated postprandial responses of PYY ...

ea0012oc13 | Placenta, bone and genetics | SFE2006

A kindred with Carney Complex due to a novel PRKAR1A gene mutation (c1067_1070 del AACG ins GCCCA)

Strey C , Randall J , Conroy S , Horvath A , Weissberg P , Berman L , Dixon A , Hoffman G , Cooper J , Firth H , Wood D , Simpson H , Chatterjee K , Stratakis C , Melvin A , Gurnell M

RP (a 60 yr-old male) was found to have multiple atrial myxomata, whilst being investigated for recurrent attacks of amaurosis fugax affecting his left eye. During the preceding twenty years he had undergone repeated resections of cutaneous tumours, which were reported as neurofibromata. A clinical diagnosis of Carney Complex (CNC) was made based on the presence of multiple cutaneous nodules and atrial myxomata. RP displayed mild acromegalic features, but no pigmentation abnor...

ea0012oc14 | Placenta, bone and genetics | SFE2006

The metabolic basis of a severe rickets-like deformity in Nigerian children

Couppis OA , Emmert W-K , Kitz K , Van’t Hoff W , Drake Stich WM

A high prevalence of rickets in the Gbagyi tribe around Kaduna, Northern Nigeria, has been noted. Multiple affected children born to one wife, but not others, of polygamous men suggests a genetic aetiology.With ethical approval, children with deformities characteristic of rickets (genu varum/valgum, rachitic rosary) were identified, clinical histories obtained and examination points documented included genu valgus/varus distances and other limb deformiti...

ea0012oc15 | Placenta, bone and genetics | SFE2006

Preliminary results from the PRISM study: a multicentre randomised controlled trial of intensive vs. symptomatic management for Paget’s disease of bone

Ralston SH , Langston AL , Campbell MK , MacLennan G , Selby PL , Fraser WD

Bisphosphonates are the treatment of choice for Paget’s disease of bone (PDB). However, long-term effects on complications are unknown. The PRISM trial was a randomised controlled trial comparing symptomatic management and intensive bisphosphonate therapy for PDB, and involved 1324 patients followed for a median of 32 months (range 12–48). Patients allocated to symptomatic therapy (n=663) were untreated unless they had bone pain, at which point they received a...

ea0012oc16 | Placenta, bone and genetics | SFE2006

Symptomatic improvement after parathyroidectomy for primary hyperparathyroidism

Mihai R , Sadler GP

IntroductionThere is growing interest in the impact of parathyroidectomy on quality of life in patients with primary hyperparathyroidism (PHPT). The aim of this study was to asses the symptomatic improvement in a cohort of patients with PHPT operated in a single centre in the UK.MethodsA prospective study of consecutive unselected patients with biochemical diagnosis of PHPT was approved by the Local Ethical C...