Searchable abstracts of presentations at key conferences in endocrinology
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197th Meeting of the Society for Endocrinology

Poster Presentations

Diabetes, metabolism and cardiovascular

ea0012p36 | Diabetes, metabolism and cardiovascular | SFE2006

The effects of Sclerocarya birrea [(a. rich.) hochst.] [Anacardiaceae] stem-bark aqueous extract on blood glucose, kidney and cardiovascular function in rats

Musabayane CT , Gondwe M , Kamadyaapa DR , Moodley K , Ojewole JAO

Available evidence suggests that Sclerocarya birrea stem-bark extract (SBE) which possesses hypoglycaemic activity may be useful in the treatment and management of diabetes mellitus. Since diabetes is associated with cardiovascular and kidney complications, we investigated the influence of SBE on blood glucose, blood pressure and renal function in some experimental animal paradigms. For OGTT tests, separate groups (n=6 in each group) of non-diabetic and streptozo...

ea0012p37 | Diabetes, metabolism and cardiovascular | SFE2006

Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin (stz)-induced diabetic rats

Musabayane CT , Bwititi P

Studies in our laboratories have demonstrated that some herbal extracts exert hypoglycaemic effects via unclear mechanism(s). Since the extracts did not have any significant effects on plasma insulin concentration, we speculated that they interfered with food intake and/or absorption to reduce blood glucose concentration. Accordingly, we monitored the amounts of food consumed and body weights in separate groups of non-diabetic and streptozotocin (STZ)-diabetic rats orally trea...

ea0012p38 | Diabetes, metabolism and cardiovascular | SFE2006

Relationship between insulin resistance and adipokines with body composition and glucose tolerance

Khan FS , Islam S , Min Y , Swaminathan R , Tait S , Lowy C

ObjectiveTo examine the relationship between leptin, adiponectin and insulin resistance in a group of men and women with varying degrees of glucose tolerance and obesity.Method69 participants were investigated and divided into four groups: 15 normal weight with normal glucose tolerance (NW NGT); 22 overweight with normal glucose tolerance (OW NGT); 15 overweight with impaired glucose tolerance (OW IGT); and 1...

ea0012p39 | Diabetes, metabolism and cardiovascular | SFE2006

Principal component analysis for the assessment of metabolic syndrome features following gestational diabetes among women of three ethnic groups

Kousta E , Godsland IF , Jeffs JAR , Efstathiadou Z , Barrett SC , Doré CJ , McCarthy MI , Johnston DG

To explore the correlation structure of individual components of the Metabolic Syndrome and identify combinations of correlated variables we used principal component analysis (PCA) in a multiethnic group of women with a history of GDM (pGDM) (185 European, 103 South Asian, 80 African–Caribbean), recruited at 20.0 (18.2–22.1) months (geometric mean (95% CI)) after pregnancy and 482 control women of similar ethnicities. BMI, W:H ratio, systolic and diastolic BP, f. glu...

ea0012p40 | Diabetes, metabolism and cardiovascular | SFE2006

Lipoatrophy can happen with any subcutaneous insulin

Farag Hussein Saleh , Coates Philip , Green Gill , Siddique Haron

Before the development of purified insulin in the 1970s, lipoatrophy was a common complication of insulin therapy (1–2). With the arrival of human insulin, lipoatrophy, becoming a rare problem in clinical practice.Lipoatrophies are considered an adverse immunological side effect of insulin therapy, and in some cases they are mediated by a local high production of tumour necrosis factor-α, w...

ea0012p41 | Diabetes, metabolism and cardiovascular | SFE2006

Type II diabetes mellitus presenting with diabetic ketoacidosis in a young obese Caucasian male

Hameed S , Lumbers T , Winocour PH

A 19 year old Caucasian male presented with nausea and malaise. In the past medical history he had been obese since childhood with hyperphagia and abnormal food seeking behaviour. His father was obese and had type I diabetes mellitus. His mother was also obese and had impaired glucose tolerance.On examination he was morbidly obese (body mass index 46.9 Kg/M2) and had axillary acanthosis nigracans. He had clinical features of hypovolaemic shock...

ea0012p42 | Diabetes, metabolism and cardiovascular | SFE2006

Cannabinoid receptors in proliferation and differentiation of white and brown adipose tissues

Agarwal N , Rees DA , Ludgate ME

BackgroundCannabinoid (CB) receptors are expressed in adipocytes. CB1 antagonism may have potential in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and via peripheral action on white adipose tissue (WAT). Equivalent studies in brown adipose tissue (BAT) are lacking.ObjectiveWe aimed to compare CB1 and CB2 receptor expression during WAT and BAT adipogenesis and to investi...

ea0012p43 | Diabetes, metabolism and cardiovascular | SFE2006

What is the relationship between testosterone and fat mass in young male cancer survivors and healthy controls?

Greenfield DM , Walters SJ , Eastell R , Coleman RE , Hancock BW , Snowden J , Ross RJ

Background and AimIt is known that the variability of testosterone concentrations is predictive of both truncal and peripheral obesity in healthy men. The aim of this study was to establish the nature of the relationship between testosterone and fat mass in young male cancer survivors compared with healthy controls.Subjects176 male cancer survivors (mean age 37.3 years SD 5.8) who previously received gonadoto...

ea0012p44 | Diabetes, metabolism and cardiovascular | SFE2006

Redox status of a hyperglycaemic cell culture model of osteoblasts supplemented with bacterial LPS and minocycline

Tilakaratne A , Soory M

ObjectiveThe aim of this investigation is to study the redox status of osteoblasts in response to glucose and bacterial lipopolysaccharide (LPS) and their response to minocycline, in a simulated diabetogenic model, using the steroid marker 5 alpha- dihydrotestosterone (DHT)MethodMonolayer cultures of MG63 osteoblasts were established in Eagle’s MEM incubated for 24 h with radiolabelled testosterone, effe...

ea0012p45 | Diabetes, metabolism and cardiovascular | SFE2006

Oxidative stress induced by TNF-alpha and glucose in an osteoblastic model and therapeutic implications of minocycline

Soory M , Tilakaratne A

ObjectiveThis study investigates the oxidative effects of tumour necrosis factor alpha (TNF) and glucose (G) in a cell culture model of osteoblasts and the modifying role of minocycline (M), using a steroid marker of wound healing (5 alpha- dihydrotestosterone: DHT). This model simulates chronic inflammation and hyperglycaemia, relevant to chronic inflammatory periodontal disease in uncontrolled diabetics and prospects of adjunctive management, using min...

ea0012p46 | Diabetes, metabolism and cardiovascular | SFE2006

A novel syndrome of extreme insulin resistance, primordial dwarfism, and gonadal failure

Semple RK , Finucane F , O’Driscoll M , Regan FM , Soos MA , Stutchfield PR , Davies JH , Dunger DB , Jeggo PA , Nolan JJ , O’Rahilly S

Single gene defects causing severe insulin resistance have been elucidated either by directed screening of candidate genes (INSR, AKT2, PPARG) or by detailed linkage mapping in large pedigrees (BSCL2, AGPAT2, LMNA), and study of patients harbouring these known defects continues to yield important insights into insulin’s action in health and disease. However a large proportion of the genetic defects leading to severe insulin resistance in slim subjects remains undiscovered...

ea0012p47 | Diabetes, metabolism and cardiovascular | SFE2006

Women gain weight and fat mass despite lipectomy at abdominoplasty and breast reduction

Bulugahapitiya DUS , Rinomhota AS , French SJ , Siyabalapitiya S , Caddy CM , Griffith RW , Ross RJ

ObjectivesRemoval of fat results in compensatory weight gain in animals. The objective of this study was to examine changes in weight and fat mass in patients who underwent lipectomy at abdominoplasty and bilateral breast reduction.MethodsIn a retrospective analysis, weight changes in 16 patients who had abdominoplasty and 17 patients who received bilateral breast reduction surgery were compared with 16 patie...

ea0012p48 | Diabetes, metabolism and cardiovascular | SFE2006

Assessment of foot problem in patients with diabetes in primary care clinics

Hosseini Roya , Baradaran Hamid Reza , Rasoli Ali

AimsTo identify the risk of foot complications in patients with diabetes.MethodsThis study was carried out on 140 patients with diabetes mellitus, including Iranian and other ethnic minority group. The study groups were identified from a diabetic clinic (hospital-based) and a diabetes research center. Risk in the study sample was assessed based on International working Group on the Diabetic Foot (IWGDF). An e...

ea0012p49 | Diabetes, metabolism and cardiovascular | SFE2006

Relation of free and bound leptin and the soluble leptin receptor to metabolic and inflammatory responses in patients with liver cirrhosis

Ockenga J , Tietge UJF , Bahr MJ , Brabant G

Leptin circulates as a free (FL) and a protein-bound (BL) form, with the soluble leptin receptor (LR) as an important binding compound. This study was set out to address the distinct role of the leptin components in the metabolic and inflammatory tissue-repair response in patients with liver cirrhosis.MethodsWe investigated hepatic substrate and leptin metabolism in 40 cirrhotics employing a combination of arterial and hepatic vein...

ea0012p50 | Diabetes, metabolism and cardiovascular | SFE2006

Evidence for a safe switch from human premixed insulin to BIAsp 30 in twice-daily regimens – data from the REACH study

McNally PG , Page S , Compion G , Lorains J

AimsThe premixed insulin analogue, biphasic insulin aspart 30/70 (BIAsp 30, 30% insulin aspart, 70% protaminated aspart) has a more physiological absorption profile than conventional premixed insulin, biphasic human insulin 30/70 (BHI 30, 30% soluble human insulin, 70% NPH), but no studies have previously tested how a switch from BHI 30 to BIAsp 30 can be done safely using a simple guideline. We investigated the occurrence of low interstitial glucose (IG...

ea0012p51 | Diabetes, metabolism and cardiovascular | SFE2006

High glucose regulates SGK1 and alpha-ENAC expression in a human cortical collecting duct cell line

Bland R , Hills CE , Ronco PM , Bennett J , Squires PE

Alterations in sodium reabsorption in collecting duct epithelium can have severe implications for the normal function of the nephron and may precipitate the development of secondary hypertension. One of the principal protein kinases involved in sodium transport in the nephron is the serum and glucocorticoid regulated kinase (SGK1) that mediates translocation and insertion of the epithelial sodium channel (ENaC) into the plasma membrane. SGK1 appears to be increased in the kidn...

ea0012p52 | Diabetes, metabolism and cardiovascular | SFE2006

Screening for HNF1α mutations in women with gestational diabetes and established diabetes in the diabetes antenatal clinic

Syed AA , Meer Lorna , Dale Jane

ObjectiveThe incidence of maturity-onset diabetes of the young (MODY) in the UK diabetic population is around 1–2% and MODY can also present for the first time in pregnancy. About 70% of cases are caused by mutations in the HNF1α gene. A diagnosis of MODY can affect management following delivery and informs patients. However, untargeted testing is not cost-effective. We wished to see whether screening a sub-group of pregnant women with a high r...

ea0012p53 | Diabetes, metabolism and cardiovascular | SFE2006

Proglucagon processing can be altered to produce GLP-1 in pancreatic alpha cells

James NM , Pritchard LE , Brennand JC , White A

The proglucagon-derived hormone, glucagon-like peptide–1 (GLP-1), augments both beta cell function and mass. However, GLP-1 is rapidly degraded in plasma, thereby limiting its potential as a treatment for diabetes. One approach to circumvent this problem would be to stimulate synthesis of GLP-1 locally in the islet.Emerging evidence suggests that pancreatic alpha cells, which normally produce glucagon, can adapt to produce GLP-1. This phenomenon may...

ea0012p54 | Diabetes, metabolism and cardiovascular | SFE2006

Prospective analysis of benefits of orthotic interventions in diabetic foot ulcers

Iqbal N , Janaka KVC , Emmerson E , Fisher A , Kirby P , Innes J , Fairbrother B , Fernando D

BackgroundInappropriate footwear is a major cause of ulceration in diabetes while good footwear prevents ulceration and recurrence.AimTo analyse the benefits of orthotic interventions in foot ulcers in our high risk diabetic patients.Design and methodsWe present preliminary data of a prospective analysis of 18 diabetic patients from our foot clinic to evaluate res...