Searchable abstracts of presentations at key conferences in endocrinology
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9th European Congress of Endocrinology

Oral Communications

Cardiovascular endocrinology

ea0014oc6.1 | Cardiovascular endocrinology | ECE2007

Growth hormone-releasing hormone prevents cardiomyocyte apoptosis and activated PI3K/AKT, ERK1/2 and CREB signaling pathways

Granata Riccarda , Trovato Letizia , Destefanis Silvia , Settanni Fabio , Annunziata Marta , Gallo Davide , Ghigo Ezio

The hypothalamic hormone growth hormone-releasing hormone (GHRH), has been shown to function via its receptor splice variants as an autocrine/paracrine growth factor in normal and malignant cell lines and tissues, besides positively regulating growth hormone (GH) synthesis and secretion from the pituitary. Moreover, GHRH antagonists are known to suppress the proliferation of a wide variety of cancer cells through mechanisms yet to be fully elucidated. Aim of this study was to ...

ea0014oc6.2 | Cardiovascular endocrinology | ECE2007

Testosterone replacement attenuates fatty streak formation and improves the HDLC profile in the Tfm mouse: an effect which is independent of the classical androgen receptor

Nettleship Joanne E , Jones Richard D , Channer Kevin S , Jones Hugh T

Research indicates that low testosterone is associated with CAD in men. Evidence suggests that men with hypotestosteronemia and concomitant CAD may benefit from physiological testosterone replacement therapy (PTRT). The mechanism by which testosterone produces these cardio-protective effects and the role of the androgen receptor remains largely unknown. The aim of this study was to determine whether testosterone modulates atheroma formation via its classical signalling pathway...

ea0014oc6.3 | Cardiovascular endocrinology | ECE2007

Plasma brain natriuretic peptide (BNP) levels predict acute right ventricular dysfunction in pulmonary embolism – prospective study on 70 patients

Pascu Alina Mihaela , Rădoi Mariana , Coculescu Mihail

Background: Acute right ventricular dysfunction (RVD) on echocardiography (ECHO) is critical for risk stratification in pulmonary embolism (PE). Plasma BNP, a consecrated marker of left ventricular dysfunction, could represent a valuable biomarker of RVD in PE.Aim and objective: Assessment of plasma BNP levels in patients with PE in relationship with right ventricular (RV) function evaluated by ECHO.Methods: Prospective study of 70...

ea0014oc6.4 | Cardiovascular endocrinology | ECE2007

Carotid IMT and stiffness, aortic stiffness and pulse pressure: association with hormone therapy in postmenopausal women: baseline findings from the CASHMERE trial

Simon T , Boutouyrie P , Christin-Maitre S , Gompel A , Joanides R , Kearny-Schwartz A , Kuntz Ch , Laurent S , Pannier B , Pornel B , Struijker-Boudier HH , Thuilliez Ch , Van Bortel L , Zannad F , Pithois-Merli I , Jaillon P

Common carotid artery intima media thickness (CCA-IMT), aortic stiffness (carotid-femoral pulse wave velocity-PWV) and central pulse pressure (PP) are early markers of atherosclerosis. The influence of hormonal replacement treatment (HRT) on arterial parameters in menopausal women remains to be investigated.We used baseline data of 665 menopausal women with hypercholesterolemia, screened for the CASHMERE study, a 12-month double-blind randomized trial co...

ea0014oc6.5 | Cardiovascular endocrinology | ECE2007

Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression in mononuclear blood cells: a randomized trial in healthy men

Gouni-Berthold Ioanna , Berthold Heiner , Gylling Helena , Ko Yon , Plat Jogchum , Krone Wilhelm

Context: Ezetimibe and simvastatin are often used in combination to lower blood lipid levels. The consequences of this combination at the molecular level are unknown.Objective: To examine their effects on the LDL receptor (LDLR) protein expression and on the LDLR and HMG-CoA reductase gene expression in peripheral blood mononuclear cells (PBMC).Design, setting and participants: Prospective, randomized, parallel 3-group trial. Twent...

ea0014oc6.6 | Cardiovascular endocrinology | ECE2007

The importance of the TAAAA(n) alleles at the SHBG gene promoter for the severity of cardiovascular disease in women

Saltiki Katerina , Xita Nectaria , Cimponeriu Adriana , Kanakakis Ioannis , Mantzou Emily , Doukas Charalambos , Georgiou Ioannis , Alevizaki Maria

Objective: Androgen may be detrimental in the development of coronary artery disease (CAD) in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and the severity of CAD in women.Methods: One hundred and twenty women (37–82 yrs), undergoing coronary angiography. CAD severity, history of angina, myocardial infa...

ea0014oc6.7 | Cardiovascular endocrinology | ECE2007

Evaluation of tolvaptan, an oral vasopressin V2 receptor antagonist, in ‘asymptomatic’ hyponatremia: effects on sodium concentration and patient reported health outcomes

Gross Peter , Verbalis Joseph , Decaux Guy , Ouyang John , Hobart Mary , Orlandi Cesare , Czerwiec Frank

Background: Hyponatremia (Na+≤134 mmol/L), the most common electrolyte derangement, is caused by inappropriate vasopressin-mediated water resorption in the kidney. Treating symptomatic hyponatremia is difficult and risky; as difficult as maintaining normal sodium levels. We tested if tolvaptan, an oral vasopressin V2 receptor antagonist, improves hyponatremia and self-reported health outcomes.Methods: Two multicenter, randomized, double-blind, plac...