Endocrine Abstracts

The mechanisms responsible for the progressive failure of hypoglycemia counter-regulation in type-1 diabetes (T1DM) are poorly understood. Alterations of brain energy metabolism could influence glucose sensing by the brain and, thus contribute to hypoglycemia associated autonomic failure. Thus, we measured intraneuronal kinetics of total ATP-synthesis from PCr (kfor) in T1DM patients and effects of hypo/hyperglycemia on this brain energy metabolism. Healthy n...

Background: Congenital Hyperinsulinism (CHI) is genetically unexplained today in up to 50% of the patients with persistent or recurrent disease. The uncoupling protein 2 (UCP2) gene is a candidate gene for medical-responsive CHI, since knock out studies have shown that UCP2 deficiency leads to increased glucose-stimulated insulin secretion.Patients and methods: In a large series of 142 patients with transient, persistent or recurrent CHI, we examined for...

Objectives: We investigated in women with prior GD (pGD) at risk of diabetes and premature atherosclerosis in comparison to women with normal glucose tolerance during and after pregnancy (C) parameters of inflammation, endothelial dysfunction and glucose tolerance in a follow-up study.Methods: 119 pGD and 41 C underwent an oral glucose tolerance test 3 months, 1 and 2 years after delivery with measurements of plasma concentrations of circulating adhesion...

Introduction: A possible involvement of proteasomes in the pathogenesis of type II diabetes mellitus has been recently reported. Therefore, association of polymorphism of proteosomal genes with type II diabetes mellitus is of particular interest. In this study, molecular markers of the proteasomal alpha subunit 6 gene PSMA6 and its adjacent genomic sites have been analyzed.The goal of this study was to characterize polymorphisms of the HSMS801, HSMS702, ...

Background: The prevalence of type 1 diabetes mellitus (DM) among patients with primary adrenal insufficiency (Addison’s disease) is 3-4 times higher than the expected prevalence in the population. The mortality rate due to DM is more than 3-fold the mortality rate in the background population. The impact of DM on mortality rate in patients with Addison’s disease is not known.Objectives: To study the frequency of DM and its impact on mortality ...

Objective: We aimed to investigate the short term effects of atorvastatin on endothelial function and oxidized LDL (oxLDL) levels and to evaluate the association of endothelial dysfunction to oxLDL levels and inflammatory markers in type 2 diabetic patients.Material and methods: After ethical committee approval thirty type 2 diabetic and 11 healthy subjects with LDL levels between 100–160 mg/dl. Without a history of cardiovascular event were include...

Renal transplantation is the optimal treatment strategy for patients with end-stage renal disease (ESRD); few are afforded the opportunity due to limited organ supply. Of the alternatives, peritoneal dialysis (PD) and hemodialysis (HD), it is unclear which confers the greater survival advantage, as prior comparisons have demonstrated conflicting results due to lack of case-mix adjustment, limited follow-up, and failure to consider switches in modality over time.<p class="a...