Endocrine Abstracts

That gonadal failure triggers osteoporosis while obesity protects from it, this led us to hypothesize that there was a common endocrine control of bone mass, body weight and reproduction. In the first phase of this work we aimed at demonstrating that there was a control of bone mass by hormones regulating body weight and reproduction. We showed that the adipocyte-derived hormone leptin regulates bone mass following its binding to hypothalamic neurons and through the use of two...