Endocrine Abstracts

Introduction: It was shown that a relationship between uric acid and cardiovascular diseases, and hyperuricemia is associated with systemic inflammation. But, determination of uric acid is widely available and inexpensive, it has been overlooked as a marker of systemic inflammation and metabolic disturbances. In this study, we aimed to evaluate uric acid value and its association with inflammation and metabolic disturbances in overweight and obese Turkish women.

Material and methods: The study population consisted of 3975 women with BMI of 25 kg/m² or greater, classified as overweight (BMI>=25 kg/m², n=771) or obese (BMI>=30 kg/m2, n=3204) by National Institutes of Health and WHO criteria. They divided two groups according to median uric acid levels. Demographic and anthropometric characteristics, blood glucose, insulin and lipid concentrations, and the indices of insulin resistance and inflammation were determined and compared between groups.

Findings: Median uric acid level was 4.40 mg/dl. Therefore, our patients were divided two groups according to median uric acid levels; i.e. 4.40 mg/dl, group 1(women with low uric acid levels; &z.lsquo; 4.40 mg/dl) and group 2 (women with high uric acid levels; &z.rsquo; 4.40 mg/dl). And metabolic parameters in group 2 having higher uric acid levels were significantly different and disturbed than group 1 with lower uric acid levels.

Conclusion: In this study, we found a significant difference in various metabolic and inflammatory parameters among different uric acid levels groups. The women with high uric acid groups have had high metabolic and inflammatory markers. These findings suggest that the relationship between uric acid and inflammatory markers. However. The nature of such a relationship remains unknown. These findings support the hypothesis that uric acid may negatively impact on metabolic parameters.