Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 14 | ECE2007 | Next issue

9th European Congress of Endocrinology


Advances in adrenal hypersecretory disorders

ea0014s8.1 | Advances in adrenal hypersecretory disorders | ECE2007

Autocrine-paracrine pathways in primary adrenal disorders

Lefebvre Hervé , Contesse Vincent , Cartier Dorthe , Perraudin Véronique , Delarue Catherine , Vaudry Hubert , Bertherat Jérôme , Plouin Pierre-François , Kuhn Jean-Marc , Louiset Estelle

It is now well demonstrated that, in the human adrenal gland, aldosterone and cortisol productions are stimulated by autocrine/paracrine factors, like serotonin (5-HT) and arginine vasopressin (AVP). Several data indicate that these signals may also be involved in the regulation of corticosteroidogenesis in adrenocortical hyperplasias and tumors. 5-HT is detected in clusters of steroidogenic cells in aldosterone-producing adrenocortical adenomas (APAs), and in both ACTH-indepe...

ea0014s8.2 | Advances in adrenal hypersecretory disorders | ECE2007

Carney complex and primary pigmented nodular adrenocortical diasease

Bertherat Jérôme

The Carney complex (CNC) is a dominantly inherited syndrome characterized by spotty skin pigmentation, endocrine overactivity and myxomas. The most common endocrine gland manifestations are acromegaly, thyroid tumors, testicular tumors, and ACTH-independent Cushing’s syndrome due to primary pigmented nodular adrenocortical disease (PPNAD). PPNAD, a rare cause of Cushing’s syndrome, is due to primary bilateral adrenal defect that can be also observed in some patients ...

ea0014s8.4 | Advances in adrenal hypersecretory disorders | ECE2007

Adrenocortical carcinoma: current and future therapeutic options

Fassnacht Martin , Hahner Stefanie , Johanssen Sarah , Koschker Ann-Cathrin , Quinkler Marcus , Allolio Bruno

Adrenocortical carcinoma (ACC) is a rare and heterogeneous malignancy with incompletely understood pathogenesis and poor prognosis. Recent data from the German ACC Registry (n=377) demonstrate an overall 5-year survival of 46%. Survival is clearly stage-dependent (P<0.01) with a 5-year survival of 85% in stage 1, 56% in stage 2, 42% in stage 3, and 16% in stage 4, respectively.In stages I –III open surgery by an expert surgeon aimi...