Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is a frequent disorder with a variable phenotype and a suspected genetic background. Androgenic effects constitute the central mechanism for the clinical, biochemical and sonographic features of PCOS. Androgenic effects are transported by the androgen receptor, whose activity can be modulated by a genetic polymorphism. We investigated the role of the CAG repeat polymorphism of the androgen receptor in PCOS.P...

Polycystic ovary syndrome (PCOS) represents the most common cause of anovulatory infertility and its etiology is still unknown. Gene expression profiles from human PCOS ovaries have identified dysregulated expression of genes encoding components of several biological pathways or systems such as Wnt signaling, extracellular matrix components, immunological factors and androgens which, seem to play a key role in the pathogenesis of PCOS.Candidate genes hav...

PCOS is a complex genetic disease resulting from the interplay between susceptibility genes and environmental factors. The syndrome is characterized by hyperandrogenism, disordered gonadotropin secretion, profound insulin resistance and, frequently, obesity. It is a leading risk factor for type 2 diabetes mellitus and MBS in adolescent and young adult women. In PCOS, MBS risk increases with increasing androgen levels, independent of insulin resistance and obesity, and antagoni...

Hyperandrogenism, hyperinsulinemia and insulin resistance are the cardinal features of most women with the polycystic ovary syndrome (PCOS). They contribute in different ways to its phenotypic expression, including hirsutism, menses abnormalities, oligo-anovulation, metabolic disturbances, and susceptibility to develop type 2 diabetes. From the theoretical point of view, individual pharmacotherapy of PCOS should be planned in order to counteract the main pathophysiological mec...