ECE2007 Poster Presentations (1) (659 abstracts)
Is there any relationship between the BsmI polymorphism in the vitamin D receptor gene and the occurrence of glucocorticoid-induced osteoporosis in asthmatic patients with long-term glucocorticoid treatment?
Urszula Tworowska 1 , Bozena Bidzinska-Speichert 1 , Andrzej Obojski 2 , Marek Demissie 1 , Ryszard Slezak 3 , Agnieszka Lenarcik 1 & Andrzej Milewicz 1
1Departament of Endocrinology and Diabetology, Medical University of Wroclaw, Wroclaw, Poland; 2Departament of Internal Medicine and Allergology, Medical University of Wroclaw, Wroclaw, Poland; 3Departament of Genetics, Medical University of Wroclaw, Wroclaw, Poland.
Introduction: Results of many studies indicate that BsmI polymorphism in VDR gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of glucocorticoid-induced osteoporosis.
Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI) and its relationship to phenotypic features characterizing bone status (BMD and metabolic bone turnover).
Material and methods: Following groups were studied: 1. asthmatic patients – no 85; divided into the subgroups: group OS – 38 patients treated with oral steroids: 27 women and 11 men (47.8±10.7 years, 74±13.8 kg), group IS – 34 patients treated with inhaled steroids: 29 women and 5 men (45.4±11.0 years, 73.7±13.9 kg), group NS – 13 patients treated with other drugs than glucocorticoids: 9 women and 4 men (38.8±15.1 years, 66.7±17.9 kg), 2. control group – 31 healthy volunteers, 17 women and 14 men (39.8±9.8 years, 75.1±16.1 kg). Serum levels of PTH, VD3, osteocalcin, ICTP, Ca and phosphates were measured. VDR gene genotypes were determined using PCR-RFLP method. BMD was measured using DXA method.
Results: Genotype bb was found in 34.3%, BB in 8.8%, and bB in 56.9%. Allelic frequency for allele B was 37.2%, and b – 62.8%. There were no significant differences regarding BMD, biochemical and hormonal parameters between any of genotypes.
Conclusions: The data suggest that the VDR genotypes do not seem to be useful for identifying patients at greater risk of glucocorticoid-induced osteoporosis, however it awaits to be confirmed by a population-based study.
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Endocrine Abstracts
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