Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2008


Hypoxia: its effects on physiology and pathophysiology

ea0015s17 | Hypoxia: its effects on physiology and pathophysiology | SFEBES2008

Hypoxia signalling and VHL

Maxwell Patrick

VHL is a classical two-hit tumor suppressor. Tumors in the familial syndrome involve somatic inactivation of the second allele, while most sporadic clear cell renal cell carcinomas and a proportion of phaeochromocytomas also exhibit biallelic inactivation of VHL. VHL disease is subclassified based on the risk of renal cell carcinoma, haemangioblastoma and phaeochromocytoma.The best-characterised function of VHL is regulation of Hypoxia-Indu...

ea0015s18 | Hypoxia: its effects on physiology and pathophysiology | SFEBES2008

Hypoxia: its short- and long-term effects on the developing fetus

Giussani Dino

In addition to traditional risks, such as smoking and obesity, the quality of our prenatal development plays a role in determining whether we suffer disease. In turn, the quality of the intrauterine environment is largely determined by the available nutrient and oxygen supply to the growing young. As such, the association between poor conditions in utero and increased risk of disease in adulthood has exploded a number of studies investigating the effects of changes in m...

ea0015s19 | Hypoxia: its effects on physiology and pathophysiology | SFEBES2008

Hypoxia, angiogenesis and proliferative diabetic retinopathy

Bishop Paul

Proliferative diabetic retinopathy is a major complication of diabetes that is characterised by the growth of new blood vessels from the pre-existing retinal circulation into the vitreous humour, i.e. it is a process of angiogenesis. The initial insult is capillary loss in the mid-peripheral and peripheral retina. The resultant retinal hypoxia stimulates the production of pro-angiogenic growth factors, with vascular endothelial growth factor and the growth hormone/insulin-like...

ea0015s20 | Hypoxia: its effects on physiology and pathophysiology | SFEBES2008

Understanding VEGF action: the role of a novel factor, Dll4

Wiegand Stanley

While it is well established that vascular endothelial growth factor-A (VEGF) is an indispensable mediator of normal and pathological angiogenesis, other molecules in the local microenvironment play important roles in modulating the proangiogenic effects of VEGF. For example, Notch receptors are expressed in the vasculature and genetic deletion of Notch1 or key downstream signaling elements results in embryonic lethality associated with vascular remodeling defects. Although mo...