Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2008

Symposia

Inflammation and the adipocyte - integrated pathways that regulate disease risk

ea0015s36 | Inflammation and the adipocyte - integrated pathways that regulate disease risk | SFEBES2008

Leptin as a proinflammatory cytokine

Lord Graham

Leptin is a 16kDa protein produced mainly by adipocytes. Animal models demonstrate that leptin is required for control of bodyweight and reproduction, since mice defective in leptin or the leptin receptor are obese, hyperphagic insulin resistant and infertile. Our initial series of observations lead us to propose that leptin also had significant effects on human type I proinflammatory immune responses. In support of this hypothesis, leptin deficient mice are resistant to a wid...

ea0015s37 | Inflammation and the adipocyte - integrated pathways that regulate disease risk | SFEBES2008

Nuclear receptors and regulation of inflammatory pathways

Staels Bart

Cardiovascular disease is significantly increased in patients with the metabolic syndrome and type 2 diabetes. A clustering of risk factors, including dyslipidemia, insulin resistance, hypertension, inflammation and coagulation disorders result in an increased risk for cardiovascular events in these patients. PPARs (Peroxisome Proliferator-Activated Receptors) and LXRs are ligand-activated transcription factors that control lipid and glucose metabolism, as well as the inflamma...

ea0015s38 | Inflammation and the adipocyte - integrated pathways that regulate disease risk | SFEBES2008

Anti-inflammatory and pro-resolution lipid mediators: lessons for obesity-related inflammation

Gilroy Derek

Inflammation is a primordial response to infection and injury that seeks to neutralise and eliminate foreign organisms and/or material. Thus, inflammation is no trivial event. Life depends upon it. In general, the innate inflammatory response initiates within minutes and resolves within hours. Chronic inflammation, on the other hand, persists for weeks, months or even years and, unlike the acute response, is the side of host immunity we need to avoid. Notwithstanding, disperse...

ea0015s39 | Inflammation and the adipocyte - integrated pathways that regulate disease risk | SFEBES2008

Adipose tissue and chronic inflammation

Kumar Sudhesh

Obesity is associated with a significantly increased risk of diabetes, cardiovascular disease and some cancers together with numerous other medical problems. During the last 10 years in particular, there has been a conceptual transformation of adipose tissue from an inert store of energy into an active endocrine organ that participates in the maintenance of normal energy homeostasis through its interactions with organs such as muscle, liver and the brain. In addition, it has b...