Endocrine Abstracts

Complex interrelated neuronal circuits have developed in the mammalian brain to regulate many aspects of feeding behaviour. An increased understanding of how peripheral energy signals act upon these circuits to regulate food intake is essential for effective treatment of the current obesity crisis.In response to meal ingestion, several hormones are released from the gastrointestinal tract, which play a role in the regulation of energy homeostasis. Peptid...

Tissue-level regeneration of active glucocorticoids (GC) by the intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) now represents a promising therapeutic target for the treatment of metabolic syndrome. Proof of principle came largely from our transgenic animal models of altered tissue GC action, which delineated 11β-HSD1 as a major determinant of intracellular GC exposure and a molecular link between ‘Cushingoid’ and idiopathic obe...