SFEBES2008 Poster Presentations Cytokines and growth factors (7 abstracts)
Relationships of IGF-I and its binding proteins to cardiac, large and small vessel structure and function in premenopausal women
Moulinath Banerjee 1 , Clare Austin 1 , Avni Vyas 1 , Kirk Siddals 2 , Martin Gibson 2 , Rayaz Malik 1 & Kennedy Cruickshank 1
1Cardiovascular Research Group, Manchester University, Manchester, UK; 2Department of Diabetes and Endocrinology, Hope Hospital, Salford, UK.
Introduction: IGF-I and its binding proteins may modulate cardiovascular risk. As part of our Manchester Mothers’ Cardiovascular study, we tested in pre-menopausal women the hypothesis that higher circulating IGF-I concentrations would be associated with lesser arterial stiffness and lower cardiac (LV) mass, while higher IGFBP1, reflecting less pre-hepatic insulin, would be positively related to small vessel function.
Methods: About 193 women aged 32±5 y had fasting blood samples, systematic anthropometry, and measures of echocardiography, aortic pulse wave velocity and heat augmented laser doppler flowmetry. In a smaller subgroup (n=29), subcutaneous small artery structure and function was assessed ex-vivo by wire myography. IGF-I and IGFBP-3 were assayed using the Immulite system, and IGFBP-1 by radio-immunoassay.
Results: On multiple regression analysis, adjusting for age, ethnicity, smoking history, BMI, systolic blood pressure, fasting glucose, total cholesterol and triglycerides, IGF-I, IGFBP1 and the IGF-I/BP-3 ratio were independently related to cardiovascular parameters as follows:
| Cardiovascular parameter | IGF indices | Beta | 95% CI of Beta | P |
| LV posterior wall thickness | IGF-I/BP-3 ratio | −0.005 | −0.009 to 0.00 | 0.04 |
| Proximal aortic distensibility | IGF-I/BP-3 ratio | −0.014 | −0.028 to 0.00 | 0.05 |
| Heat augmented | IGF-I/BP-3 ratio | 0.05 | 0.007 to 0.094 | 0.03 |
| microcirculatory flow by laser doppler | Ln IGFBP1 | −0.66 | −1.09 to −0.22 | 0.004 |
| Subcutaneous | IGF-I/BP-3 ratio | 2.09 | 1.54 to 2.63 | <0.001 |
| small artery | Total IGF-I | 0.19 | 0.07 to 0.31 | 0.003 |
| media:lumen ratio | Ln IGFBP1 | −28.0 | −44.85 to −11.17 | 0.002 |
Conclusion: In pre-menopausal women, higher concentrations of IGF-I, perhaps ‘free’ IGF-I (as indicated by the IGF-I/BP-3 ratio) and of IGFBP-1 had positive influences on cardiac, large and small vessel function.
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Endocrine Abstracts
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