Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 15 P133

SFEBES2008 Poster Presentations Diabetes, metabolism and cardiovascular (51 abstracts)

Retinol binding protein 4 and adiponectin multimers in obesity: influence on insulin resistance and effects of weight reduction

U Bradley 1 , M Spence 2 , MC McKinley 2 , CN Ennis 1 , CH Courtney 1 , J McEneny 2 , PM Bell 1 , IS Young 2 & SJ Hunter 1

1Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland, UK; 2Nutrition and Metabolism Group, The Queen’s University of Belfast, Belfast, Northern Ireland, UK.

Altered adipokine levels may explain the link between obesity and insulin resistance. One potential candidate is retinol binding protein 4 (RBP4) which is elevated in type 2 diabetes and correlates with the magnitude of insulin resistance. Low adiponectin levels are also associated with insulin resistance. Adiponectin circulates in multimeric complexes and multimer distribution may also be important.

We measured RBP4 and adiponectin multimers in 24 obese non-diabetic subjects, BMI 33.6±0.8 kg/m2 (mean±S.E.M.), age 39±2 years, before and following 8 weeks diet-induced weight loss. Insulin sensitivity was measured by the hyperinsulinaemic euglycaemic clamp.

RBP4 levels reduced following weight loss (30.4±10.6 vs 25.3±8.3 P=0.03). However, there was no correlation between RBP4 and glucose infusion rate (GIR) at baseline (r=0.12, P=0.6) or between the diet-induced changes of RBP4 and GIR (r=0.21 P=0.9).

Total, high molecular weight (HMW) and low molecular weight (LMW) adiponectin multimers increased with weight loss (0.35, 0.12 and 0.17 μg/ml respectively compared to baseline, all P<0.05). Total and HMW but not LMW forms of adiponectin correlated with GIR at baseline (r=0.69 P<0.001, r=0.69 P<0.001, r=−0.35 P=0.87). There were no correlations between diet-induced changes of adiponectin multimers and GIR.

In contrast to previous studies there was no association between RBP4 and insulin resistance. Furthermore changes in RBP4 did not account for changes in insulin resistance following weight loss. HMW but not LMW adiponectin was associated with insulin resistance but not diet-induced changes. Diet-induced changes in insulin resistance were not related to changes in RBP4 or adiponectin.

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