Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 15 P359

SFEBES2008 Poster Presentations Thyroid (68 abstracts)

Improvements in quality of life in hypothyroid patients taking Armour thyroid

DH Lewis , J Kumar , P Goulden & DJ Barnes

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Maidstone and Tunbridge Wells NHS Trust, Tunbrige Wells, Kent, UK.


Armour thyroid (Armour) is unlicensed in the UK for the treatment of hypothyroidism. It is natural porcine-derived thyroid replacement with 1 grain containing 38 mcg levothyroxine (T4) and 9 mcg L-triiodothyronine (T3), and unspecified amounts of T1, T2 and calcitonin. We have used Armour as a third line agent in selected patients who have not responded adequately to T4 monotherapy, and combination T4/T3 therapy since 2003.

Aim: To assess changes in symptoms of hypothyroidism in patients treated with Armour.

Methods: Forty patients (38 female) who had been prescribed Armour between 2005 and 2006 were identified using hospital Pharmacy records. A simple questionnaire was sent to these patients to assess changes to quality of life whilst they were taking Armour.

Results: Thirty-five patients (88%) returned the questionnaire. All patients had been prescribed either T4 and/or combination T4/T3 therapy before commencing Armour. Twenty-nine were still taking Armour at the time of the questionnaire. Three of these twenty-nine patients did not answer the quality of life questions, one of whom was unable to tolerate T4 and T3 due to nausea.

Of the patients still taking Armour, 72% found improvement in energy levels, 52% dry skin, 52% hair loss and 55% cold intolerance. There was no difference in constipation, arthragia, myalgia or ability to lose weight. Most patients (62%) had improvements in 3 or more symptoms of hypothyroidism.

In the 6 patients who were no longer taking Armour, there were no significant improvements in any parameter.

Conclusion: In appropriately selected hypothyroid patients, Armour appears to improve the quality of life in patients who have either had an inadequate clinical response to conventional T4/T3 therapy or are unable to tolerate such therapy.

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